Use of lactobacilli and their pheromone-based regulatory mechanism in gene expression and drug delivery.


:Lactobacilli are common microorganisms in diverse vegetables and meat products and several of these are also indigenous inhabitants in the gastro-intestinal (GI) tract of humans and animals where they are believed to have health promoting effects on the host. One of the highly appreciated probiotic effects is their ability to inhibit the growth of pathogens by producing antimicrobial peptides, so-called bacteriocins. Production of some bacteriocins has been shown to be strictly regulated through a quorum-sensing based mechanism mediated by a secreted peptide-pheromone (also called induction peptide; IP), a membrane-located sensor (histidine protein kinase; HPK) and a cytoplasmic response regulator (RR). The interaction between an IP and its sensor, which is highly specific, leads to activation of the cognate RR which in turn binds to regulated promoters and activates gene expression. The HPKs and RRs are built up by conserved modules, and the signalling between them within a network is efficient and directional, and can easily be activated by exogenously added synthetic IPs. Consequently, components from such regulatory networks have successfully been exploited in construction of a number of inducible gene expression systems. In this review, we discuss some well-characterised quorum sensing networks involved in bacteriocin production in lactobacilli, with special focus on the use of the regulatory components in gene expression and on lactobacilli as potential delivery vehicle for therapeutic and vaccine purposes.


Curr Pharm Biotechnol


Diep DB,Mathiesen G,Eijsink VG,Nes IF




Has Abstract


2009-01-01 00:00:00












  • GqPCR-mediated signalling in the spotlight: from visualization towards dissection and quantification.

    abstract::Signals relayed through G protein-coupled receptors (GPCR) play pivotal roles in human physiology and are important drug targets. About 40% of all GPCRs couple to the heterotrimeric G protein Gq. Biochemical studies as well as crystallography have improved our understanding of GqPCRs and their downstream partners. Her...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Jalink K,Adjobo-Hermans MJ

    更新日期:2014-01-01 00:00:00

  • Antibacterial and Potential Antidiabetic Activities of Flavone C-glycosides Isolated from Beta vulgaris Subspecies cicla L. var. Flavescens (Amaranthaceae) Cultivated in Egypt.

    abstract:BACKGROUND:Diabetes mellitus is the most common disease in Egypt. In this context, Beta vulgaris subspecies cicla L. var. flavescens is an edible plant that has been used in traditional medicine as a therapy for treating some diseases. OBJECTIVES:The current study was performed to evaluate the antibacterial and potent...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Mohammed HS,Abdel-Aziz MM,Abu-Baker MS,Saad AM,Mohamed MA,Ghareeb MA

    更新日期:2019-01-01 00:00:00

  • Prevalence of Multi-Drug Resistant Tuberculosis among Tuberculosis Patients Attending Chest Clinics in Osun-State, Nigeria.

    abstract:BACKGROUND:The development of multidrug-resistant tuberculosis (MDR-TB) poses a considerable threat to tuberculosis control programmes in Nigeria. There is an increase in the prevalence of MDR-TB worldwide both among new tuberculosis cases as well as previously-treated ones. There is also a rise in transmission of resi...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Oyedeji GJ,Adeyemo C,Dissou A,Abiodun T,Alli OAT,Onaolapo OJ,Onaolapo AY,Adesiji Y,Olowe OA

    更新日期:2020-01-01 00:00:00

  • Ex-ante evaluation of biotechnology innovations: the case of folate biofortified rice in China.

    abstract::In order to valorize novel biotechnology innovations, there is a need to evaluate ex-ante their market potential. A case in point is biofortification, i.e. the enhancement of the micronutrient content of staple crops through conventional or genetic breeding techniques. In a recent article in Nature Biotechnology, for ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: De Steur H,Blancquaert D,Gellynck X,Lambert W,Van Der Straeten D

    更新日期:2012-12-01 00:00:00

  • Nitrite and Nitrate Levels in Groundwater, Water Distribution Network, Bottled Water and Juices in Iran : A systematic Review.

    abstract:BACKGROUND:Nitrate and nitrite can get into the body through the consumption of contaminated water either directly or indirectly. The accumulation of these compounds in the body, in the long run, leads to health problems, for example, digestive disorders, cancers, and even death threats in children. The aim of this rev...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Marhamati M,Afshari A,Kiani B,Jannat B,Hashemi M

    更新日期:2020-12-03 00:00:00

  • Accidental Thawing of Embryos, Cryopreserved for Transfer. Two Italian cases, Milan and Rome.

    abstract::The bioethical and juridical debate on the status of frozen embryos sometimes adds new issues arising from new scientific evidence or by accidental occurrences that bring to the attention of the scientific community the need for new practical solutions. Within this scenario, there have been, in recent years, episodes ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Busardò FP,Vergallo GM,Turillazzi E,Bolino G,Vullo A,Frati P

    更新日期:2016-01-01 00:00:00

  • Vaccines against Clostridium perfringens alpha-toxin.

    abstract::Clostridium perfringens alpha-toxin is thought to be an important agent in gas gangrene, which is a lifethreatening infection with fever, pain, edema, myonecrosis, and gas production. The toxin (370 residues) is composed of an N-terminal domain (1-250 residues, N-domain) in which the catalytic site is found and a C-te...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Nagahama M

    更新日期:2013-01-01 00:00:00

  • The high pH and pH-shift refolding technology.

    abstract::We have developed a high-pH, pH-shift refolding "Ph-Fold technology", both for academic research and industrial protein drug development applications. Using this technology, we were able to refold some "difficult-to-refold" proteins, some of which are proven important drug targets and protein drug candidates. The tech...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Lin X,Umetsu T

    更新日期:2010-04-01 00:00:00

  • In silico search for drug targets of natural compounds.

    abstract::Natural compounds represent a significant source for the development of novel medicines. Finding the target proteins for a natural compound is the most important step towards understanding its molecular mechanism for therapeutic usage. In fact, the search for target proteins could be considered the first step of the d...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Yao L

    更新日期:2012-07-01 00:00:00

  • Antifungal Activity, Gas Chromatographic-Mass Spectrometric Analysis And in silico Study of Punica Granatum Peel Extracts Against Fluconazole Resistant Strains of Candida Species.

    abstract:AIMS:Candida species is the common cause of opportunistic fungal infections all over the world with increased mortality and morbidity especially in immunosuppressed patients. Fluconazole is the first line therapy for candidiasis. The antifungal resistance pattern in high-risk patients is a major concern. The present st...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Paul S,Mohanram K,Kannan I

    更新日期:2018-01-01 00:00:00

  • Complete response in 5 out of 38 patients with advanced hepatocellular carcinoma treated with stem cell differentiation stage factors: case reports from a single centre.

    abstract::Hepatocellular carcinoma (HCC) represents the third cause of cancer-related death. Because HCC is multi-centric with time, excluding the few transplanted patients, sooner or later it becomes untreatable with loco-regional therapies and, until some years ago, it was not responsive to systemic therapies. In 2005 a rando...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Livraghi T,Ceriani R,Palmisano A,Pedicini V,Pich MG,Tommasini MA,Torzilli G

    更新日期:2011-02-01 00:00:00

  • Atherosclerosis and vascular disease: effects of peptide mimetics of apolipoproteins.

    abstract::Levels of high density lipoprotein (HDL) and its major protein component, apolipoprotein (apo) A-I, are strongly inversely correlated to risk of atherosclerosis and other vascular diseases. A number of properties of apo A-I may contribute to this protection, including removal of cholesterol from peripheral tissues to ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Garber DW,Handattu SP,Datta G,Mishra VK,Gupta H,White CR,Anantharamaiah GM

    更新日期:2006-08-01 00:00:00

  • Key questions in metastasis: new insights in molecular pathways and therapeutic implications.

    abstract::The metastatic cascade and colonization remains a major challenge in clinical therapeutics. The formation of metastasis has many rate limiting steps. The expression of metastases initiation genes in primary tumors is driven by the need for cell motility, invasiveness, handling the shear stress in the vasculature and l...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Gueron G,De Siervi A,Vazquez E

    更新日期:2011-11-01 00:00:00

  • Nanosuspension as an Efficient Carrier for Improved Ocular Permeation of Voriconazole.

    abstract:BACKGROUND:The present limitations related to the ocular administration of antifungal drugs for the treatment of fungal keratitis include poor ocular bioavailability, limited retention time, and low ocular tissues penetration. METHODS:This study aimed to prepare a novel ophthalmic voriconazole-loaded nanosuspension ba...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Qin T,Dai Z,Xu X,Zhang Z,You X,Sun H,Liu M,Zhu H

    更新日期:2020-08-20 00:00:00

  • Cell engineering and cultivation of chinese hamster ovary (CHO) cells.

    abstract::Mammalian cell lines are important host cells for the industrial production of pharmaceutical proteins owing to their capacity for correct folding, assembly and post-translational modification. In particular, Chinese hamster ovary (CHO) cells are the most dependable host cells for the industrial production of therapeu...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Omasa T,Onitsuka M,Kim WD

    更新日期:2010-04-01 00:00:00

  • Vancomycin Therapeutic Regime Adjustment in Newborns and Infants with Bacterial Infection: Case Series.

    abstract:BACKGROUND:Vancomycin is used mostly to overcome infections caused by methicillinresistant microorganisms. There are no well-established administration protocols for neonates and infants, so the leak of a specific administration regime in that population may lead to serum concentrations beyond the specified range. OBJ...

    journal_title:Current pharmaceutical biotechnology



    authors: Bidu NS,Fernandes BJD,Dias EJC,Filho JNC,Bastos REA,Godoy ALPC,Azeredo FJ,Pedreira JNR,Couto RD

    更新日期:2019-01-01 00:00:00

  • Potential Use of Pentoxifylline in Cancer Therapy.

    abstract:BACKGROUND:Pentoxifylline (PTX) is a drug commonly used in the treatment of intermittent claudication. However, numerous research groups report that PTX also may potentially be used in the anticancer therapy following one of the main trends in the nowadays medicine - combined anticancer therapy. SCOPE OF REVIEW:The re...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Golunski G,Woziwodzka A,Piosik J

    更新日期:2018-01-01 00:00:00

  • Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting.

    abstract::Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Gotz W,Papageorgiou SN

    更新日期:2017-01-01 00:00:00

  • 18F-labeled proteins.

    abstract::Positron emission tomography (PET) is a powerful and rapidly developing area of molecular imaging that is used to study and visualize human physiology by the detection of positron-emitting radiopharmaceuticals. Information about metabolism, receptor/enzyme function, and biochemical mechanisms in living tissue can be o...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Wu Z,Kandeel F

    更新日期:2010-09-01 00:00:00

  • Mechanisms underlying the hepatotoxic effects of ecstasy.

    abstract::3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a worldwide illegally used amphetamine-derived designer drug known to be hepatotoxic to humans. Jaundice, hepatomegaly, centrilobular necrosis, hepatitis and fibrosis represent some of the adverse effects caused by MDMA in the liver. Although there is irrefutable ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Carvalho M,Pontes H,Remião F,Bastos ML,Carvalho F

    更新日期:2010-08-01 00:00:00

  • ESR1, ESR2 and FSH receptor gene polymorphisms in combination: a useful genetic tool for the prediction of poor responders.

    abstract:PURPOSE:Previous studies in humans concluded that a multigenic model including specific FSHR, ESR1 and ESR2 genotype patterns may partially explain the poor response to FSH. The aim of our study is to analyse three different loci -polymorphisms in ESR1 Pvu II, ESR2 Rsa I and Ser680Asn FSH receptor gene- in a Greek popu...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Anagnostou E,Mavrogianni D,Theofanakis C,Drakakis P,Bletsa R,Demirol A,Gurgan T,Antsaklis A,Loutradis D

    更新日期:2012-03-01 00:00:00

  • Current research on protein-protein interactions among auxin-signaling factors in regulation of plant growth and development.

    abstract::In many signaling pathways, various factors have been isolated by molecular genetic studies and wholegenome analysis. Understanding the interactions among these factors is crucial to understanding the signaling process as a whole. Recent studies on auxin signaling in the regulation of plant growth and development have...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Muto H,Kinjo M

    更新日期:2012-11-01 00:00:00

  • Immuno-isolation in oncology--a mini-review.

    abstract::Immuno-isolation provides a potentially safe and effective method of delivering recombinant therapeutic molecules. Its application as a drug-delivery platform for the treatment of cancer has shown promising developments recently. This review will summarize the principle and current progress of this novel therapy parad...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Cirone P,Saller RM,Chang PL

    更新日期:2001-09-01 00:00:00

  • Formulation and Evaluation of Atorvastatin Calcium-Poly-ε-Caprolactone Nanoparticles Loaded Ocular Inserts for Sustained Release and Antiinflammatory Efficacy.

    abstract:PURPOSE:The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. METHODS:First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanop...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章


    authors: Girgis GNS

    更新日期:2020-01-01 00:00:00

  • Proteomic-based biomarker discovery with emphasis on cerebrospinal fluid and multiple sclerosis.

    abstract::Discovery of disease specific biomarkers in human body fluids has become an important challenge in clinical proteomics. Facing the increasing threat of degenerative and disabling diseases like cancer, cardiovascular, neurological and inflammatory diseases in large parts of the world's population, there is an urgent ne...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Berven FS,Flikka K,Berle M,Vedeler C,Ulvik RJ

    更新日期:2006-06-01 00:00:00

  • Nucleic-Acid Delivery Using Lipid Nanocapsules.

    abstract::Lipid nanocapsules (LNCs) were designed more than 15 years ago to deliver lipophilic drugs to cells with non toxic excipients by mimicking lipoproteins. During the last 5 years these promising nanocarriers were re-designed to deliver nucleic acids to cancer cells. This short review sums up the features of LNCs and des...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Lagarce F,Passirani C

    更新日期:2016-01-01 00:00:00

  • Use of transgenic mouse models to understand the origins of familial pulmonary fibrosis.

    abstract::Pulmonary fibrosis is an unremitting degenerative lung disease that has an associated high mortality. The major pathological features include the growth of fibroblasts, emergence of myofibroblasts and their production of extracellular matrix that distorts the peripheral lung tissue and impairs respiratory function. Ef...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Glasser SW,Senft AP

    更新日期:2011-09-01 00:00:00

  • Food with Influence in the Sexual and Reproductive Health.

    abstract:BACKGROUND:Sexual dysfunction and infertility are conditions with high prevalence in the general population. Nutritional factors have been reported to have an impact on sexual and reproductive health. OBJECTIVE:The aim of this review is to summarize the data on nutritional factors that have influence on male and femal...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Silva T,Jesus M,Cagigal C,Silva C

    更新日期:2019-01-01 00:00:00

  • Advances in biotechnology for tissue engineering of bone.

    abstract::Tissue engineering is a rapidly developing field applying the disciplines of cell biology, developmental biology, molecular biology and biomimetic engineering to regenerate new tissues for replacement therapies in clinical contexts. To aid in the elicitation and reiteration of the processes of morphogenesis of tissues...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Ripamonti U,Tasker JR

    更新日期:2000-07-01 00:00:00

  • Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery.

    abstract::Platelet concentrates for surgical use are innovative tools of regenerative medicine, and were widely tested in oral and maxillofacial surgery. Unfortunately, the literature on the topic is contradictory and the published data are difficult to sort and interpret. In bone graft, implant and reconstructive surgery, the ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审


    authors: Simonpieri A,Del Corso M,Vervelle A,Jimbo R,Inchingolo F,Sammartino G,Dohan Ehrenfest DM

    更新日期:2012-06-01 00:00:00