Developmental angiogenesis of the central nervous system.

Abstract:

:The vasculature of the central nervous system (CNS) is highly specialized with a blood-brain-barrier, reciprocal neuroepithelial-endothelial cell interactions and extensive pericyte coverage. Developmentally, numerous important signaling pathways participate in CNS angiogenesis to orchestrate the precise timing and spatial arrangement of the complex CNS vascular network. From a therapeutic standpoint, the CNS vasculature has attracted increased attention since many human ailments, such as stroke, retinopathy, cancer and autoimmune disease are intimately associated with the biology of CNS blood vessels. This review focuses on growth factor pathways that have been shown to be important in developmental CNS vascularization through studies of mouse genetic models and human diseases.

journal_name

Lymphat Res Biol

authors

Mancuso MR,Kuhnert F,Kuo CJ

doi

10.1089/lrb.2008.1014

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

173-80

issue

3-4

eissn

1539-6851

issn

1557-8585

journal_volume

6

pub_type

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