Abstract:
:Basic and animal research implicate inflammatory mechanisms in the pathogenesis and progression of atherosclerosis, plaque rupture, thrombosis, and stroke. Inflammatory biomarkers, particularly high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2, have been identified as potential predictors of stroke risk and prognosis. Infections may also precipitate stroke. Medications, especially hydroxymethylglutaryl coenzyme A reductase inhibitors (statins), reduce inflammatory marker levels independently of lipid effects, and the ability of statins to reduce coronary events and stroke correlates with their effect on inflammatory biomarkers. Vaccination against influenza may also reduce stroke risk. Determining whether reduction of biomarkers reduces risk of recurrent stroke, however, requires further study before inflammatory markers become a routine part of the evaluation of stroke patients.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Elkind MSdoi
10.1007/s11886-009-0003-2subject
Has Abstractpub_date
2009-01-01 00:00:00pages
12-20issue
1eissn
1523-3782issn
1534-3170journal_volume
11pub_type
杂志文章,评审abstract::Controlled clinical trials, performed in more than 13,000 patients, have consistently shown the beneficial effects of long-term beta-blocker therapy in patients with chronic heart failure. However, it is not clear whether this is a class effect or if it is specific only for some agents. Beneficial effects on the progn...
journal_title:Current cardiology reports
pub_type: 杂志文章
doi:10.1007/s11886-000-0076-4
更新日期:2000-05-01 00:00:00
abstract::Patients with pre-diabetes have a tenfold higher risk of developing Type 2 DM and a twofold higher risk of developing coronary heart disease compared to non-diabetics. Interventions targeted at those in an early stage of impaired glucose metabolism can delay or prevent diabetes. Effects of these interventions on cardi...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-015-0562-3
更新日期:2015-03-01 00:00:00
abstract::Heart failure is becoming increasingly prevalent, and currently coronary artery disease (CAD) is the primary cause of left ventricular (LV) systolic dysfunction. A potential therapeutic option for patients with severe CAD and LV dysfunction is a strategy of revascularization. In this review, we summarize the available...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-006-0055-5
更新日期:2006-07-01 00:00:00
abstract::Exercise training is beneficial in healthy adults as well as patients with acquired cardiovascular disease such as coronary artery disease and heart failure. While a reduced exercise capacity is common in adults with congenital heart disease, it is not clear if these patients stand to benefit from exercise training or...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-013-0416-9
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Ebstein's anomaly (EA) is a rare, but complex form of congenital heart disease consisting of a right ventricular myopathy and morphologic tricuspid valve disease leading to a high incidence of right ventricular dysfunction and arrhythmias. This review offers an updated overview of the current understa...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01412-z
更新日期:2020-10-09 00:00:00
abstract::This review focuses on the use of bivalirudin as a replacement anticoagulant for heparin in patients undergoing percutaneous coronary intervention, or who are being treated for unstable angina pectoris, ST-elevation, or non-ST-elevation myocardial infarction. Potential advantages of bivalirudin include a lack of depen...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-001-0050-9
更新日期:2001-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The present article reviews the pathophysiology of cardiac sympathetic denervation, the principles of positron emission tomography (PET) imaging of the sympathetic innervation of the heart and its potential clinical role, based on current and expected future evidence. RECENT FINDINGS:Imaging of cardi...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01432-9
更新日期:2020-11-27 00:00:00
abstract::Coronary artery bypass grafting without the aid of cardiopulmonary bypass (CPB) continues to gain popularity as an alternative to standard techniques of revascularization. CPB with cardioplegic arrest is associated with complications that may negate an otherwise technically flawless procedure. Experience has identifie...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-999-0056-2
更新日期:1999-11-01 00:00:00
abstract::Revascularization in stable ischemic heart disease (SIHD) is indicated in patients on optimal medical therapy with angina and/or demonstrable ischemia and a significant stenosis in one or more epicardial coronary arteries. Angiography alone, however, cannot accurately determine the hemodynamic significance of coronary...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0711-3
更新日期:2016-04-01 00:00:00
abstract::Although overall stroke incidence has been declining in developed countries, there is evidence that stroke in the young is increasing. Increasing incidence may be particularly pronounced among minorities in whom historically a higher burden of stroke has been reported. Compared with older adults, time spent with disab...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-013-0421-z
更新日期:2013-12-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Moderate or severe aortic regurgitation (AR) occurs in 0.5% of the population and typically peaks in the fourth to sixth decade of life. A significant proportion of patients have prohibitive surgical risk and are therefore treated medically with pharmacological management of heart failure and no d...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01338-6
更新日期:2020-07-28 00:00:00
abstract:PURPOSE OF REVIEW:To review the clinical evidence on the use of percutaneous coronary intervention (PCI) revascularization options in left main (LM) disease in comparison with coronary artery bypass graft (CABG). Coronary artery disease (CAD) involving the LM is associated with high morbidity and mortality. Though CABG...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-1268-8
更新日期:2020-02-08 00:00:00
abstract::Spontaneous coronary artery dissection is an important etiology of nonatherosclerotic acute coronary syndrome, myocardial infarction, and sudden death. Innovations in the catheterization laboratory including optical coherence tomography and intravascular ultrasound have enhanced the ability to visualize intimal disrup...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0737-6
更新日期:2016-07-01 00:00:00
abstract::Catheter-based aortic valve implantation is increasingly being performed in high-risk patients with symptomatic aortic valve stenosis. For successful planning of the procedure, CT has been shown to provide crucial information concerning the aortic root as well as the peripheral access vessels. This article illustrates...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-015-0696-3
更新日期:2016-02-01 00:00:00
abstract::Heart failure is a major public health concern that is frequently complicated by ventricular arrhythmias. Sustained ventricular tachycardia is associated with an increased risk for progressive heart failure and sudden death. We summarize the current management strategies for ventricular tachycardia in heart failure pa...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-011-0182-5
更新日期:2011-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review was to synthesize research findings from recently published randomized controlled trials (RCTs) targeting any phase of medication adherence, from initiation to discontinuation, among patients with coronary heart disease (CHD). RECENT FINDINGS:We identified successful strate...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0918-y
更新日期:2017-09-22 00:00:00
abstract::While pulmonary arterial hypertension is a disease primarily affecting the pulmonary vasculature, the right ventricle plays an integral part in the disease process. Although widely used, two-dimensional echocardiography is limited in visualizing the right ventricle and, therefore, assessment of its structure and funct...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-012-0253-2
更新日期:2012-06-01 00:00:00
abstract::Atrial fibrillation (AF) is a very common tachyarrhythmia and is becoming increasingly prevalent, while dementia is a neurological condition manifested as loss of memory and cognitive ability. Both these conditions share several common risk factors. It is becoming increasingly evident that AF increases the risk of dem...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-014-0519-y
更新日期:2014-08-01 00:00:00
abstract:PURPOSE OF REVIEW:This review describes the effects of psychological stress on the physiology of the entire vascular system, from individual cellular components to macrovascular and microvascular responses, and highlights the importance of the vascular system in the context of current limitations in cardiac imaging for...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01406-x
更新日期:2020-10-09 00:00:00
abstract::Low serum levels of high-density lipoprotein cholesterol (HDL-C) are highly prevalent and are recognized as an independent risk factor for cardiovascular morbidity (myocardial infarction, stroke, peripheral arterial disease, and restenosis after coronary stenting) and mortality. HDL plays an important role in modulati...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-008-0077-2
更新日期:2008-11-01 00:00:00
abstract::A number of reports demonstrate the importance of serum triglyceride values in predicting the clinical onset of vascular disease. However, adjustment for measurements highly correlated with triglyceride (TG) levels, such as history of diabetes, body mass index, and high-density lipoprotein cholesterol (HDL-C), lessen ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-001-0060-7
更新日期:2001-09-01 00:00:00
abstract::Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies that causes long-term damage of various organs including the cardiovascular system. A consistent observation shows that DM amplifies the risk of cardiovascular events by 4- to 6-fold. Since coronary artery disease (CAD) in diabetic patients exhibits...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-012-0323-5
更新日期:2013-01-01 00:00:00
abstract::Randomized clinical trials have established that lipid- lowering pharmacologic therapy can substantially reduce morbidity and mortality in patients with known coronary artery disease (CAD). Researchers are now working to define the role of lipid-lowering agents in the primary prevention of CAD to extend their benefit ...
journal_title:Current cardiology reports
pub_type: 杂志文章
doi:10.1007/s11886-000-0056-8
更新日期:2000-09-01 00:00:00
abstract::The accurate differentiation of viable and nonviable myocardium is crucial for therapy planning in patients with coronary artery disease and left ventricular dysfunction. Traditional techniques such as echocardiography, positron emission tomography, single photon emission computed tomography, and dobutamine echocardio...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-005-0012-8
更新日期:2005-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Variant angina, which is characterized by recurrent chest pain and transient ECG changes along with angiographic evidence of coronary artery spasm, generally has a favorable prognosis. However, episodes of ischemia caused by vasospasm may lead to potentially life-threatening ventricular arrhythmias an...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-0963-1
更新日期:2018-03-08 00:00:00
abstract::Although clinical evidence indicates that many of the electrophysiologic and functional changes associated with atrial fibrillation (AF) can be reversed by maintaining normal sinus rhythm (NSR), a series of large-scale randomized trials failed to demonstrate that this strategy provides a survival advantage. These stud...
journal_title:Current cardiology reports
pub_type: 杂志文章
doi:10.1007/s11886-006-0078-y
更新日期:2006-09-01 00:00:00
abstract::The scientific selection of antithrombotic therapy has been dominated by group-based interpretation of data in the form of probability-based statistics in evidence-based medicine. Because the data in large randomized trials are grouped and averaged, the relationship to initial conditions of the patient is lost. There ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-003-0083-3
更新日期:2003-03-01 00:00:00
abstract::Primary aldosteronism with a prevalence of 8 % of hypertension and 20 % of pharmacologically resistant hypertension is the most common secondary cause of hypertension. Yet, the diagnosis is missed in the vast majority of patients. Current clinical practice guidelines recommend screening for primary aldosteronism in pa...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0774-1
更新日期:2016-10-01 00:00:00
abstract::Anticoagulation has proven to be a key component in the management of acute coronary syndromes (ACS). Pharmacological agents with various modes of action are utilized to reduce thrombus development by impairing thrombin formation, platelet activation, and platelet aggregation. The optimal management of these patients ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-012-0286-6
更新日期:2012-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe lipid abnormalities in diabetes, when they occur and the evidence base for lipid management with established and new drugs to prevent diabetes complications. We also discuss how to manage statin intolerance. RECENT FINDINGS:Statins remain first-line therapy in patients with diabetes, thou...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-019-1246-1
更新日期:2019-11-22 00:00:00