Inflammatory markers and stroke.

Abstract:

:Basic and animal research implicate inflammatory mechanisms in the pathogenesis and progression of atherosclerosis, plaque rupture, thrombosis, and stroke. Inflammatory biomarkers, particularly high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2, have been identified as potential predictors of stroke risk and prognosis. Infections may also precipitate stroke. Medications, especially hydroxymethylglutaryl coenzyme A reductase inhibitors (statins), reduce inflammatory marker levels independently of lipid effects, and the ability of statins to reduce coronary events and stroke correlates with their effect on inflammatory biomarkers. Vaccination against influenza may also reduce stroke risk. Determining whether reduction of biomarkers reduces risk of recurrent stroke, however, requires further study before inflammatory markers become a routine part of the evaluation of stroke patients.

journal_name

Curr Cardiol Rep

authors

Elkind MS

doi

10.1007/s11886-009-0003-2

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

12-20

issue

1

eissn

1523-3782

issn

1534-3170

journal_volume

11

pub_type

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