Abstract:
:Liver failure is still a significant clinical problem after transplantation surgery, tissue resections (the Pringle manoeuvre) and haemorrhagic shock. The restoration of blood flow to an ischaemic region leads to tissue injury at a greater rate than the original ischaemic insult, an event termed "ischaemia-reperfusion injury" (I/R). Despite advances in surgical techniques, I/R still poses a problem of clinical importance. In this research, we studied the effect of simvastatin pretreatment on liver and lung injury induced by hepatic I/R. Rats were subjected to 30 min of ischaemia followed by 24 h of reperfusion. Simvastatin (10 mg/kg) was administered orally from three days before the operation. After the reperfusion time, serum ALT, AST, LDH and TNF a levels were studied and liver and lung tissues were stained with haematoxylin and eosin and TUNEL to detect apoptotic cells. Serum aminotransferase activity and LDH and TNFalpha levels were increased markedly by hepatic I/R, and these were suppressed significantly by simvastatin. The tissue injury index and the number of apoptotic cells via TUNEL staining in the liver and lungs were higher in the I/R group than in the I/R + simvastatin group. These results suggest that simvastatin ameliorates I/R-induced liver and lung tissue damage by inhibiting the level of inflammation and the apoptotic pathways. Simvastatin administration may therefore provide protection against the adverse effects of I/R injury in liver transplantation.
journal_name
Folia Morphol (Warsz)journal_title
Folia morphologicaauthors
Dibazar F,Hajipour B,Hosseinian MM,Hemmati MR,Ghandiha Asubject
Has Abstractpub_date
2008-11-01 00:00:00pages
231-5issue
4eissn
0015-5659issn
1644-3284journal_volume
67pub_type
杂志文章abstract:BACKGROUND:The present study aims to summarise the accessory muscles of the anterior thoracic wall and axilla that can be encountered during breast and axillary surgery and record their incidence and clinical significance. Moreover, the laterality of the atypical muscles is highlighted and possible gender dimorphism is...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2019.0005
更新日期:2019-01-01 00:00:00
abstract::Both the adrenergic and the cholinergic components of the autonomic nervous system (ANS) have been found to be an important source of nerve fibres supplying the lungs. On the other hand, data regarding the innervation of the pulmonary tissue in breeding animals are surprisingly scarce. Therefore, in the present study ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Neural and vascular variations in the axilla and upper limb area are usually paired, but coexistence of muscular aberration on top of this is uncommon. The current case report emphasizes on the unilateral coexistence of a three-headed (tricipital) biceps brachii muscle, a two-headed coracobrachialis with an accessory ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2018.0081
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Diastema is a space between teeth. The most often is maxillary midline diastema between upper central incisors. One of the main causes of diastema is enlarged upper lip frenulum attachment. The aim of the study was to assess frenulum attachment in patients with diastema and investigate if type of upper lip f...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2016.0079
更新日期:2017-01-01 00:00:00
abstract::Adrenergic and cholinesterase-positive (AChE-positive) innervation of the bovine oviduct was studied using histochemical methods. Both subpopulations of the studied nerve fibres were found in the isthmus, ampulla and infundibulum where they were mainly related to the muscular coat or blood vessels of the organ. The ad...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Mylohyoid bridging (MB) is a non-metrical variant of the human mandible. The incidence and types of MB were investigated in 264 mandibles (edentulous 116, semi-dentulous 90 and dentulous 58). No mandible showed a complete type of MB, although 19 (7.2%) mandibles had a partial type. These were classified into two subty...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
abstract::Goldenhar syndrome (GS) is a well-recognised condition characterised by variable degree of uni- or bilateral involvement of craniofacial structures involving first and second branchial arches manifesting ocular and auricular anomalies and also vertebral defect. This syndrome presents at birth and its exact aetiology i...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/fm.2013.0060
更新日期:2013-11-01 00:00:00
abstract::Measurements were made of the femoral shaft/neck angle (CCD angle) in 106 human foetuses, aged from 16 to 38 hbd, using a "FEM-GEO_03" computer program. The values of the CCD angle in the group under examination were: mean = 140.48 degrees, SD = 6.95 degrees, max = 157.90 degrees, min = 113.93 degrees. No significant ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::In 17th week old fetus the interganglionic rami of the thoracic sympathetic trunk are mainly composed of bundles of unmylinated fibers. The well myelinated fibers have 11 compact myelin lamellae. Although many fibers are already myelinated, fibers in various phases of myelinogenesis are found. ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The aim of our study was to determine the localisation of the inferior margin of the optic canal in relation to the infraorbital canal/groove complex (IOC/G complex) and zygomaticoorbitale (ZO) as the potential useful landmarks for reducing dangerous complications following surgical and invasive procedures. ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2015.0013
更新日期:2015-01-01 00:00:00
abstract::Third molar teeth are causative factors of many oral pathologies. Lower third molars are the most often retained teeth and the origin of considerable pain. The aim of the study is a presentation of the morphology of third molars with incompletely formed apices on the basis of panoramic radiograms. The material compris...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::The aim of the study was to evaluate the physiological developmental changes of male rats' lumbar vertebrae during the first 22 days after birth. Morphology and mineralisation of lumbar vertebrae were evaluated using double-staining and digital radiography system, which allowed vertebral width and optical density to b...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2015.0068
更新日期:2016-01-01 00:00:00
abstract::During routine dissections carried out in the course of our medical gross anatomy work, an unusual structure was found unilaterally on the left side of an adult male cadaver. Upon investigation, this was determined to be a hugely dilated transverse facial artery. Also noted was the complete absence of the ipsilateral ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:The aim of this paper was to summarise the anatomical knowledge on the subject of the maxillary nerve and its branches, and to show the clinical usefulness of such information in producing anaesthesia in the region of the maxilla. MATERIALS AND METHODS:A literature search was performed in Pubmed, Scopus, We...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2015.0025
更新日期:2015-01-01 00:00:00
abstract::We compared the effects of rosmarinic acid and dexpanthenol in a rat experimental wound model. Twenty-four Wistar albino rats weighing 200-250 g were randomly divided into 3 groups. After 2-cm full-thickness skin defects were created, the wounds were washed with sterile 0.9% NaCl solution. After washing, the control g...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2020.0097
更新日期:2020-08-26 00:00:00
abstract::Localisation of the diaphorase activity of nicotinamide adenine dinucleotide phosphate (NADPH-d), acting as a marker of nitric oxide synthesis (NOS), was studied in the thymus of the rat, mouse and rabbit. The NADPH-d-active cells observed in the rat thymus were irregular in shape with numerous projections and were lo...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Importance is placed on aberrant arteries in the radiological and surgical literature. A normal left brachiocephalic trunk is characteristic for the right aortic arch. However, an aberrant left brachiocephalic trunk arising as the last branch of the aortic arch on the left side has not yet been described in the litera...
journal_title:Folia morphologica
pub_type: 杂志文章,评审
doi:
更新日期:2005-02-01 00:00:00
abstract::The frequency of occurrence and topography of the outfow portions of the posterior veins of the left ventricle were observed. One hundred fifty adult human hearts of both sexes from l8 to 85 years of age fixed in a formalin/ethanol solution were examined. Classical macroscopic anatomical examination methods were used....
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Normally the 7th cervical vertebra (C7) has a long non-bifid spine. A bifid spine is a feature of typical cervical vertebrae such as C3--C6. In contrast to past studies, which have described a bifid spine in the C3--C6 cervical vertebrae, this study is a report on the presence of a duplicated spinous process in the C7...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::The main blood supply of the thalamus constitute internal branches of the posterior cerebral, posterior communicating, middle, and choroid arteries. Branches of these arteries from three groups of vessels: medial, lateral, and posterior. Considering the number of vessels, their diameter and direct origin from the cere...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Sertoli cells are important in determining the fate of spermatogenic cells by providing nutrition and structural support via cell junctions. Adhesion between Sertoli and germ cells is important for spermatogenesis. Cadherin are transmembrane proteins that mediate cell-cell adhesion, while, vimentin, the cyto...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2014.0050
更新日期:2014-08-01 00:00:00
abstract::It was found in sheep that the left cranial vena cava formed by two brachiocephalic veins terminated in coronary sinus together with left azygous vein and great as well middle cardiac veins. The right azygous vein escapes into right atrium. In dog two cranial venae cavae were observed. The right vena cava terminated i...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Spinosin, a major component of Samen Ziziphi spinosae, has been shown to modulate sedation and hypnosis; however, the underlying neuronal mechanisms of its stimulatory effects remain unclear. MATERIALS AND METHODS:In the present study, we injected spinosin (15 mg/kg) or saline into mice, which were killed a...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2019.0118
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to identify and compare the various morphological characteristics of rugae palatinae in males and females of adult Sudanese Nubians and to assess the existence of side asymmetry. Furthermore, the possibility of assigning sex utilising dimensions, shapes, and orientations was explore...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2015.0046
更新日期:2015-01-01 00:00:00
abstract::The aim of this work was to evaluate the morphology and asymmetry of the ovale and spinous foramina. Examinations were carried out on 102 mediaeval and 85 contemporary male skulls. In both groups there predominated individuals who had died at mature (maturus) and adult (adultus) age. Radiological images in occipital p...
journal_title:Folia morphologica
pub_type: 历史文章,杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The left ventricular (LV) hypertrophy increases the risk of heart failure. Hypertension and infiltrative cardiomyopathies are the well-known reasons of LV hypertrophy. The growing interest of scientists in this issue affects hereditary haemochromatosis (HH), which is characterised by the excess deposition of...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2019.0025
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The anatomy of the human nasal cavity (NC) is complex and its structures are closely related to the functions of the NC. Studies which assessing the mean volumes of NC and conchae are very infrequent. The purpose of current study is to investigate development of NC and conchae according to age and sex by usi...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2015.0078
更新日期:2016-01-01 00:00:00
abstract::A rare variation was found in one of the two left renal veins in a 94-year-old male cadaver undergoing routine dissection. The characteristic findings in the cadaver included, in addition to the primary left renal vein, the presence of a posterior left renal vein draining to the left ascending lumbar vein without comm...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2015.0121
更新日期:2015-01-01 00:00:00
abstract::Systematic sampling using the Cavalier's principle provides accurate, efficient, cheap, and simple quantitative estimates of objects within neuroanatomical structures like the cerebellum. We identified and isolated the Purkinje cell layer and used this information to extrapolate the stereological technique to estimate...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2011-11-01 00:00:00
abstract::Anatomical variations of the transverse cervical and suprascapular arteries are common. We report an adult male cadaver found to harbour an unusual variation of the right course of these two arteries. The transverse cervical artery arose independently from the first segment of the subclavian artery and passed deep to ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00