Abstract:
:We previously isolated a Saccharomyces cerevisiae mutant (HsTnII), which displays 40% reduced chronological lifespan as compared to the wild type (WT). In this study, we found HsTnII cultures to be characterized by fragmented and dysfunctional mitochondria, and by increased initiation of apoptosis during chronological aging as compared to WT. Expression of genes encoding subunits of mitochondrial electron transport chain and ATP synthase is significantly downregulated in HsTnII, and as a consequence, HsTnII is not able to respire ethanol. All these data confirm the importance of functional mitochondria and respiration in determining yeast chronological lifespan and apoptosis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Aerts AM,Zabrocki P,Govaert G,Mathys J,Carmona-Gutierrez D,Madeo F,Winderickx J,Cammue BP,Thevissen Kdoi
10.1016/j.febslet.2008.11.028subject
Has Abstractpub_date
2009-01-05 00:00:00pages
113-7issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00939-3journal_volume
583pub_type
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