Pulse steroid therapy.

Abstract:

:Intravenous supra-pharmacological doses of corticosteroids are used in various inflammatory and autoimmune conditions because they are cumulatively less toxic than sustained steroid treatment at lower quantitative dosage. Their action is supposed to be mediated through non-genomic actions within the cell. Common indications for use in children include steroid resistant and steroid dependent nephrotic syndrome, rapidly progressive glomerulonephritis, systemic vasculitis, systemic lupus erythematosus, acute renal allograft rejection, juvenile rheumatoid arthritis, juvenile dermatomyositis, pemphigus, optic neuritis, multiple sclerosis and acute disseminated encephalomyelitis. Methylprednisolone and dexamethasone show similar efficacy in most conditions. Therapy is associated with significant side effects including worsening of hypertension, infections, dyselectrolytemia and behavioral effects. Adequate monitoring is essential during usage.

journal_name

Indian J Pediatr

authors

Sinha A,Bagga A

doi

10.1007/s12098-008-0210-7

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1057-66

issue

10

eissn

0019-5456

issn

0973-7693

journal_volume

75

pub_type

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