Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.

abstract：BACKGROUND:The endothelial PAS domain protein 1 (EPAS1) activates genes that are involved in erythropoiesis and angiogenesis, thus favoring a better delivery of oxygen to the tissues and is a plausible candidate to influence athletic performance. Using innovative statistical methods we compared genotype distributions a...

journal_title：BMC genomics

authors： Voisin S,Cieszczyk P,Pushkarev VP,Dyatlov DA,Vashlyayev BF,Shumaylov VA,Maciejewska-Karlowska A,Sawczuk M,Skuza L,Jastrzebski Z,Bishop DJ,Eynon N

更新日期：2014-05-18 00:00:00

abstract：BACKGROUND:Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod vector, which involves an obligate sexual cycle. As assessed using ...

journal_title：BMC genomics

authors： Henson S,Bishop RP,Morzaria S,Spooner PR,Pelle R,Poveda L,Ebeling M,Küng E,Certa U,Daubenberger CA,Qi W

更新日期：2012-09-23 00:00:00

abstract：BACKGROUND:The identification and quantification of proteins using label-free Liquid Chromatography/Mass Spectrometry (LC/MS) play crucial roles in biological and biomedical research. Increasing evidence has shown that biomarkers are often low abundance proteins. However, LC/MS systems are subject to considerable noise...

journal_title：BMC genomics

authors： Zhang J,Haskins W

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Genome-scale functional genomic screens across large cell line panels provide a rich resource for discovering tumor vulnerabilities that can lead to the next generation of targeted therapies. Their data analysis typically has focused on identifying genes whose knockdown enhances response in various pre-defin...

journal_title：BMC genomics

authors： Zhu Z,Ihle NT,Rejto PA,Zarrinkar PP

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:For centuries roses have been selected based on a number of traits. Little information exists on the genetic and molecular basis that contributes to these traits, mainly because information on expressed genes for this economically important ornamental plant is scarce. RESULTS:Here, we used a combination of ...

journal_title：BMC genomics

authors： Dubois A,Carrere S,Raymond O,Pouvreau B,Cottret L,Roccia A,Onesto JP,Sakr S,Atanassova R,Baudino S,Foucher F,Le Bris M,Gouzy J,Bendahmane M

更新日期：2012-11-20 00:00:00

abstract：BACKGROUND:The colonial cyanobacterium Microcystis proliferates in a wide range of freshwater ecosystems and is exposed to changing environmental factors during its life cycle. Microcystis blooms are often toxic, potentially fatal to animals and humans, and may cause environmental problems. There has been little invest...

journal_title：BMC genomics

authors： Frangeul L,Quillardet P,Castets AM,Humbert JF,Matthijs HC,Cortez D,Tolonen A,Zhang CC,Gribaldo S,Kehr JC,Zilliges Y,Ziemert N,Becker S,Talla E,Latifi A,Billault A,Lepelletier A,Dittmann E,Bouchier C,de Marsac NT

更新日期：2008-06-05 00:00:00

abstract：BACKGROUND:Ocean acidification (OA), a change in ocean chemistry due to the absorption of atmospheric CO2 into surface oceans, challenges biogenic calcification in many marine organisms. Ocean acidification is expected to rapidly progress in polar seas, with regions of the Southern Ocean expected to experience severe O...

journal_title：BMC genomics

authors： Johnson KM,Hofmann GE

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:The transcriptome and its regulation bridge the genome and the phenome. Recent RNA-seq studies unveiled complex transcriptomes with previously unknown transcripts and functions. To investigate the characteristics of neural transcriptomes and possible functions of previously unknown transcripts, we analyzed a...

journal_title：BMC genomics

authors： Sun Y,Wang Y,Hu Y,Chen G,Ma H

更新日期：2011-10-10 00:00:00

abstract：BACKGROUND:Despite the recent identification of several prognostic gene signatures, the lack of common genes among experimental cohorts has posed a considerable challenge in uncovering the molecular basis underlying hepatocellular carcinoma (HCC) recurrence for application in clinical purposes. To overcome the limitati...

journal_title：BMC genomics

authors： Kim BY,Choi DW,Woo SR,Park ER,Lee JG,Kim SH,Koo I,Park SH,Han CJ,Kim SB,Yeom YI,Yang SJ,Yu A,Lee JW,Jang JJ,Cho MH,Jeon WK,Park YN,Suh KS,Lee KH

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Avian infectious bronchitis virus (IBV) is a gamma coronavirus that severely affects the poultry industry worldwide. Long non-coding RNAs (lncRNAs), a subset of non-coding RNAs with a length of more than 200 nucleotides, have been recently recognized as pivotal factors in the pathogenesis of viral infections...

journal_title：BMC genomics

authors： Li H,Cui P,Fu X,Zhang L,Yan W,Zhai Y,Lei C,Wang H,Yang X

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities on endogenous genomic substrates. RESULTS:To enable functional analysis of human transposase-derived genes, we comb...

journal_title：BMC genomics

authors： Henssen AG,Jiang E,Zhuang J,Pinello L,Socci ND,Koche R,Gonen M,Villasante CM,Armstrong SA,Bauer DE,Weng Z,Kentsis A

更新日期：2016-08-04 00:00:00

abstract：BACKGROUND:The phytoflagellated protozoan, Euglena gracilis, has been proposed as an attractive feedstock for the accumulation of valuable compounds such as β-1,3-glucan, also known as paramylon, and wax esters. The production of wax esters proceeds under anaerobic conditions, designated as wax ester fermentation. In s...

journal_title：BMC genomics

authors： Yoshida Y,Tomiyama T,Maruta T,Tomita M,Ishikawa T,Arakawa K

更新日期：2016-03-03 00:00:00

abstract：BACKGROUND:Complete or near-complete genomic sequence information is presently only available for a few plant species representing a large phylogenetic diversity among plants. In order to effectively transfer this information to species lacking sequence information, comparative genomic tools need to be developed. Molec...

journal_title：BMC genomics

authors： Fredslund J,Madsen LH,Hougaard BK,Nielsen AM,Bertioli D,Sandal N,Stougaard J,Schauser L

更新日期：2006-08-14 00:00:00

abstract：BACKGROUND:The mitochondrial genomes of higher plants vary remarkably in size, structure and sequence content, as demonstrated by the accumulation and activity of repetitive DNA sequences. Incompatibility between mitochondrial genome and nuclear genome leads to non-functional male reproductive organs and results in cyt...

journal_title：BMC genomics

authors： Li S,Chen Z,Zhao N,Wang Y,Nie H,Hua J

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:Pharmacological and gene ablation studies have demonstrated the crucial role of the endocrine function of the heart as mediated by the polypeptide hormones ANF and BNP in the maintenance of cardiovascular homeostasis. The importance of these studies lies on the fact that hypertension and chronic congestive h...

journal_title：BMC genomics

authors： McGrath MF,de Bold AJ

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Mycoviruses are viruses that naturally infect and replicate in fungi. Aspergillus fumigatus, an opportunistic pathogen causing fungal lung diseases in humans and animals, was recently shown to harbour several different types of mycoviruses. A well-characterised defence against virus infection is RNA silencin...

journal_title：BMC genomics

authors： Özkan S,Mohorianu I,Xu P,Dalmay T,Coutts RHA

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs that regulate genes at the post-transcriptional level in spatiotemporal manner. Several miRNAs are identified as prognostic and diagnostic markers in many human cancers. Estimation of the temporal activities of the miRNAs is an important step in the way to underst...

journal_title：BMC genomics

authors： Jayavelu ND,Bar N

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Panax notoginseng (Burk) F.H. Chen is important medicinal plant of the Araliacease family. Triterpene saponins are the bioactive constituents in P. notoginseng. However, available genomic information regarding this plant is limited. Moreover, details of triterpene saponin biosynthesis in the Panax species ar...

journal_title：BMC genomics

authors： Luo H,Sun C,Sun Y,Wu Q,Li Y,Song J,Niu Y,Cheng X,Xu H,Li C,Liu J,Steinmetz A,Chen S

更新日期：2011-12-23 00:00:00

abstract：BACKGROUND:The food spoilage yeast species Zygosaccharomyces bailii exhibits an extraordinary capacity to tolerate weak acids, in particular acetic acid. In Saccharomyces cerevisiae, the transcription factor Haa1 (ScHaa1) is considered the main player in genomic expression reprogramming in response to acetic acid stres...

journal_title：BMC genomics

authors： Palma M,Dias PJ,Roque FC,Luzia L,Guerreiro JF,Sá-Correia I

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:The complete sequences of chloroplast genomes provide wealthy information regarding the evolutionary history of species. With the advance of next-generation sequencing technology, the number of completely sequenced chloroplast genomes is expected to increase exponentially, powerful computational tools annota...

journal_title：BMC genomics

authors： Liu C,Shi L,Zhu Y,Chen H,Zhang J,Lin X,Guan X

更新日期：2012-12-20 00:00:00

abstract：INTRODUCTION:In the classification of Mass Spectrometry (MS) proteomics data, peak detection, feature selection, and learning classifiers are critical to classification accuracy. To better understand which methods are more accurate when classifying data, some publicly available peak detection algorithms for Matrix assi...

journal_title：BMC genomics

authors： Liu Q,Sung AH,Qiao M,Chen Z,Yang JY,Yang MQ,Huang X,Deng Y

更新日期：2009-07-07 00:00:00

abstract：BACKGROUND:Sacha Inchi (Plukenetia volubilis L., Euphorbiaceae) is a potential oilseed crop because the seeds of this plant are rich in unsaturated fatty acids (FAs). In particular, the fatty acid composition of its seed oil differs markedly in containing large quantities of α-linolenic acid (18C:3, a kind of ω-3 FAs)....

journal_title：BMC genomics

authors： Wang X,Xu R,Wang R,Liu A

更新日期：2012-12-20 00:00:00

abstract：BACKGROUND:The completion of the Plasmodium falciparum genome represents a milestone in malaria research. The genome sequence allows for the development of genome-wide approaches such as microarray and proteomics that will greatly facilitate our understanding of the parasite biology and accelerate new drug and vaccine ...

journal_title：BMC genomics

authors： Lu F,Jiang H,Ding J,Mu J,Valenzuela JG,Ribeiro JM,Su XZ

更新日期：2007-07-27 00:00:00

abstract：BACKGROUND:The pituitary is a critical neuroendocrine gland that is comprised of five hormone-secreting cell types, which develops in tandem during the embryonic stage. Some essential genes have been identified in the early stage of adenohypophysial development, such as PITX1, FGF8, BMP4 and SF-1. However, it is likely...

journal_title：BMC genomics

authors： Ma Y,Qi X,Du J,Song S,Feng D,Qi J,Zhu Z,Zhang X,Xiao H,Han Z,Hao X

更新日期：2009-03-15 00:00:00

abstract：BACKGROUND:The ultimate phenome of any organism is modulated by regulated transcription of many genes. Characterization of genetic makeup is thus crucial for understanding the molecular basis of phenotypic diversity, evolution and response to intra- and extra-cellular stimuli. Chickpea is the world's third most importa...

journal_title：BMC genomics

authors： Ashraf N,Ghai D,Barman P,Basu S,Gangisetty N,Mandal MK,Chakraborty N,Datta A,Chakraborty S

更新日期：2009-09-05 00:00:00

abstract：BACKGROUND:The variability in gene organization and architecture of green algal mitochondrial genomes is only recently being studied on a finer taxonomic scale. Sequenced mt genomes from the chlorophycean orders Volvocales and Sphaeropleales exhibit considerable variation in size, content, and structure, even among clo...

journal_title：BMC genomics

authors： Farwagi AA,Fučíková K,McManus HA

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:Although prokaryotic gene transcription has been studied over decades, many aspects of the process remain poorly understood. Particularly, recent studies have revealed that transcriptomes in many prokaryotes are far more complex than previously thought. Genes in an operon are often alternatively and dynamica...

journal_title：BMC genomics

authors： Li S,Dong X,Su Z

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Tandemly arranged nuclear ribosomal DNA (rDNA), encoding 18S, 5.8S and 26S ribosomal RNA (rRNA), exhibit concerted evolution, a pattern thought to result from the homogenisation of rDNA arrays. However rDNA homogeneity at the single nucleotide polymorphism (SNP) level has not been detailed in organisms with ...

journal_title：BMC genomics

authors： Matyášek R,Renny-Byfield S,Fulneček J,Macas J,Grandbastien MA,Nichols R,Leitch A,Kovařík A

更新日期：2012-12-23 00:00:00

abstract：BACKGROUND:Rich in genetic information and cost-effective to genotype, the Insertion-Deletion (InDel) molecular marker system is an important tool for studies in genetics, genomics and for marker-assisted breeding. Advent of next-generation sequencing (NGS) revolutionized the speed and throughput of sequence data gener...

journal_title：BMC genomics

authors： Lv Y,Liu Y,Zhao H

更新日期：2016-04-14 00:00:00

abstract：BACKGROUND:Cotton, one of the world's leading crops, is important to the world's textile and energy industries, and is a model species for studies of plant polyploidization, cellulose biosynthesis and cell wall biogenesis. Here, we report the construction of a plant-transformation-competent binary bacterial artificial ...

journal_title：BMC genomics

authors： Lee MK,Zhang Y,Zhang M,Goebel M,Kim HJ,Triplett BA,Stelly DM,Zhang HB

更新日期：2013-03-28 00:00:00