Abstract:
:Autism is diagnosed on the basis of a triad of impairments in social interaction, communication, and flexible imaginative functions (with restricted and repetitive behaviors and interests; RRBIs). There has been a strong presumption that these different features of the syndrome are strongly intertwined and proceed from a common cause at the genetic, cognitive and neural levels. In this review we examine evidence for an alternative approach, considering the triad as largely 'fractionable'. We present evidence from our own twin studies, and review relevant literature on autism and autistic-like traits in other groups. We suggest that largely independent genes may operate on social skills/impairments, communication abilities, and RRBIs, requiring a change in molecular-genetic research approaches. At the cognitive level, we suggest that satisfactory accounts exist for each of the triad domains, but no single unitary account can explain both social and nonsocial features of autism. We discuss the implications of the fractionable-triad approach for both diagnosis and future research directions.
journal_name
Neuropsychol Revjournal_title
Neuropsychology reviewauthors
Happé F,Ronald Adoi
10.1007/s11065-008-9076-8subject
Has Abstractpub_date
2008-12-01 00:00:00pages
287-304issue
4eissn
1040-7308issn
1573-6660journal_volume
18pub_type
杂志文章,评审abstract::In the previous 15 years, a variety of experimental paradigms and methods have been employed to study inhibition. In the current review, we analyze studies that have used the high temporal resolution of the event-related potential (ERP) technique to identify the temporal course of inhibition to understand the various ...
journal_title:Neuropsychology review
pub_type: 杂志文章,评审
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journal_title:Neuropsychology review
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journal_title:Neuropsychology review
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pub_type: 杂志文章,评审
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