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Developmental kinetics of hemopoietic progenitors in the avian embryo spleen.

Abstract：

:By means of plasma clot clonal cultures, the content of the avian spleen in granulomonocytic progenitors was studied during ontogeny. Serum-free media were used that were supplemented with growth activities produced either by embryonic fibroblasts or adult spleen cells. These two conditioned media not only permitted the growth of M-CFC, G-CFC, and GM-CFC but also F-CFU (fibroblast colony-forming units) from quail or chick embryonic spleen cells. The presence of spleen cell-conditioned medium promoted the development of large colonies of immature granulocytes. In the chick the first hemopoietic progenitors appeared at E9 and their number displayed two peaks, one at E15 and a smaller one at E18. In the quail the first progenitors were detected as early as E7 and their number peaked at E10. In this species, hemopoietic progenitors disappeared definitively before hatching while in the chick some were still present at P3. The progenitor content of the chick embryo spleen was compared to that of the bone marrow. This content remained stable during all of embryonic life, while the bone marrow exhibited a very different profile, where a sharp peak at E16 was followed by an acute decline and a stabilization at a rather low level. The particular profile in the spleen speaks in favor of a special role of this organ in the development of the hemopoietic system.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Nicolas-Bolnet C,Yassine F,Cormier F,Dieterlen-Lièvre F

doi

10.1016/0014-4827(91)90264-u

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

294-301

issue

2

eissn

0014-4827

issn

1090-2422

journal_volume

196

pub_type

杂志文章

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