Abstract:
:Increasingly in the field of medicine, new therapeutic modalities, both surgical and non-surgical, are being introduced. Some of these may significantly alter the pathological appearance of normal and neoplastic tissue and result in problems for the pathologist. In this review, iatrogenic pathology within the female genital tract is described, especially concentrating on the recent literature. Pathological artefacts within the female genital tract are also reviewed. Topics covered include mechanical displacement of normal and neoplastic elements into vascular or tissue spaces and thermal artefacts. Recently described pathological findings in neoplastic and non-neoplastic tissue secondary to hormonal, chemotherapeutic and other medications are discussed. Changes associated with non-surgical management of uterine leiomyomas are also described. It behoves the pathologist to be aware of these iatrogenic lesions and artefacts in order to prevent diagnostic errors.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Clarke B,McCluggage WGdoi
10.1136/jcp.2008.061424subject
Has Abstractpub_date
2009-02-01 00:00:00pages
104-12issue
2eissn
0021-9746issn
1472-4146pii
jcp.2008.061424journal_volume
62pub_type
杂志文章,评审abstract:AIM:IgG4 disease is rare. However, IgG4 tubulointerstitial nephritis (TIN) is the most common renal manifestation. IgG4 disease is usually associated with elevated serum IgG4 levels and other organ involvement, low-density renal lesions on enhanced CT imaging and immune activation. The incidence of IgG4-TIN may be unde...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2016-203905
更新日期:2017-06-01 00:00:00
abstract::One hundred and two bone marrow samples were analysed by histological and immunohistochemical methods for neurone specific enolase (NSE). The biopsies were performed to determine the extent of bone marrow disease in 84 neuroblastomas, nine embryonal rhabdomyosarcomas, five Ewing's sarcomas, two cases of Hodgkin's dise...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.4.309
更新日期:1991-04-01 00:00:00
abstract::A woman with peripheral vascular disease developed cytomegalovirus colitis following repair of abdominal aortic aneurysm. Cytomegalovirus colitis developing in an immunocompetent individual may be caused by a breach in the integrity of the mucosal lining of the colon from various causes and should alert the clinician ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.6.475
更新日期:1998-06-01 00:00:00
abstract::Lymphoid tissue of the endometrium was analysed by histological, immunohistological, and electron microscopical methods in 10 healthy uteri. A panel of monoclonal antibodies recognising macrophages (OKMI), HLA-DR antigen, B lymphocytes, T lymphocytes and their subsets, and dendritic reticulum cells was used in a two s...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.6.644
更新日期:1985-06-01 00:00:00
abstract:AIM:To investigate serum placental-type alkaline phosphatase (PLAP-type) activities in women with squamous and glandular malignancies of the reproductive tract using an immunoradiometric assay. METHODS:PLAP-type immunoreactivity was measured in 180 women with non-ovarian malignancies of the reproductive tract and the ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.11.1035
更新日期:1994-11-01 00:00:00
abstract::The term "dysplastic" melanocytic naevus has recently been used to describe pigmented naevi with unusual histological and clinical features. There is currently no clear clinical or pathological definition of the term, and this has led to a lack of comparability of material described in reports on these lesions. As a r...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.39.2.189
更新日期:1986-02-01 00:00:00
abstract::Seven commercially available screening tests for rheumatoid factor and two quantitative tests have been compared with the standard Rose-Waaler test in a series of 477 sera from patients with various joint diseases. Markedly different results were obtained, and on the basis of our findings suggestions are made as to wh...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.27.5.368
更新日期:1974-05-01 00:00:00
abstract:AIMS:A series of patients with myeloma were investigated to assess whether immunological risk factors predisposing to serious infection could be identified. METHODS:Patients (n = 102) with predominantly plateau phase myeloma were monitored prospectively for infections. Immunological parameters including total non-para...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.3.260
更新日期:1995-03-01 00:00:00
abstract::Platelet adhesiveness was measured in patients undergoing operation. With the rotating bulb technique adhesiveness increased steadily to the sixth and ninth days following surgery. The glass bead filter technique demonstrated a marked increase in platelet adhesiveness on the day following operation. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.20.5.708
更新日期:1967-09-01 00:00:00
abstract:AIMS:To investigate the correlation between centrally assessed human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH) results and response to treatment of patients with metastatic breast cancer enrolled in a first-line, phase II, open-label, 3-weekly tra...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2006.043562
更新日期:2008-01-01 00:00:00
abstract:AIMS:Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. METHODS:The expression of MUC...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.56.5.378
更新日期:2003-05-01 00:00:00
abstract::A new staining method was developed for the detection of inclusions of Chlamydia psittaci and Chlamydia trachomatis inclusions in cell cultures. Using a combination of methyl green and neutral red stains and washing at pH 5.0, inclusions were stained red while cell cytoplasm was pale pink and cell nuclei were pale gre...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.6.642
更新日期:1982-06-01 00:00:00
abstract::Laribacter hongkongensis is a Gram-negative, facultative anaerobic, motile, S-shaped, urease-positive bacillus associated with invasive infections in liver cirrhosis patients and community-acquired gastroenteritis. Most cases of L hongkongensis infections occur in eastern countries. Information is lacking on the usefu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2013-201651
更新日期:2013-12-01 00:00:00
abstract::This review focuses on the pathological features of dysplasia in Barrett's oesophagus. Two categorisation schemes are used for grading dysplasia in the gastrointestinal tract, including Barrett's oesophagus. The inflammatory bowel disease dysplasia morphology study group system is the one most commonly used in the USA...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2005.035337
更新日期:2006-10-01 00:00:00
abstract:AIMS:The signalling system of phosphoinositides (PIs) is involved in a number of cell and tissue functions including membrane trafficking, ion channel activity, cell cycle, apoptosis, differentiation and cell and tissue polarity. Recently, a role in cell migration was hypothesised for PI and related molecules including...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2011-200096
更新日期:2011-10-01 00:00:00
abstract:AIMS:The authors previously demonstrated that nasal mucus cyclic adenosine 3', 5'-monophosphate (cAMP) and cyclic 3', 5'-guanosine monophosphate (cGMP) were lower in patients with smell and taste dysfunction than in normal individuals. To learn more about these differences this study related levels of nasal mucus cAMP ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2012-200698
更新日期:2012-05-01 00:00:00
abstract::A severe non-dose related skin eruption attributable to treatment with captopril was recently reported: this is distinct from the dose related rashes that have been widely described. Ultrastructural and immunohistochemical studies were carried out to determine in detail the histological features of this eruption: the ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.39.8.902
更新日期:1986-08-01 00:00:00
abstract::Here, we report the pathological findings of nine complete autopsies of individuals who died in community settings in the UK, three of which were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), three tested negative for SARS-CoV-2 but are likely false negatives, and three died of other respi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206710
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Fatty liver disease (FLD), of either alcoholic (AFLD) or non-alcoholic (NAFLD) aetiologies, is characterised histologically by features that are lobulocentric that typically affect zone 3, in contrast with portal-based inflammation characteristics of other forms of chronic liver disease. AIM:The authors aim...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2010.079145
更新日期:2010-09-01 00:00:00
abstract::A technique, using indirect immunoperoxidase antibody (IPA), was developed for the detection of IgG antibody to Chlamydia trachomatis. The IPA technique employs glass slides with air-dried and acetone-fixed C trachomatis infected cells, which can be stored at -70 degrees C and used for several months. Antibody titres ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.3.353
更新日期:1983-03-01 00:00:00
abstract:AIMS:To isolate RNA and DNA simultaneously from formalin fixed paraffin wax embedded tissue to assess the clonality of enteropathy associated T cell lymphomas and to analyse it in detail by a non-radioactive method of T cell receptor complementarity determining region 3 (CDR3) spectratyping. METHODS:DNA and RNA were i...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.10.811
更新日期:1997-10-01 00:00:00
abstract::A polyclonal antiserum, produced in sheep and reactive against purified human leucocyte elastase, has been applied to paraffin sections from a range of human tissues by means of the indirect immunoperoxidase method. Striking and consistent results have been obtained. Normal or inflammatory granulocytes were intensely ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.10.1114
更新日期:1984-10-01 00:00:00
abstract:AIMS:To study the localisation of the endothelial nitric oxide synthase (eNOS) in the normal placenta, with special emphasis on the implantation site in the first trimester of pregnancy, and in the different subtypes of trophoblastic cells in gestational trophoblastic disease. METHODS:The immunoperoxidase technique wi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.6.427
更新日期:1998-06-01 00:00:00
abstract:AIMS:The aim of this study was to assess the prevalence and drug resistance of Ureaplasma species and Mycoplasma hominis in outpatients with genital manifestation from 2005 to 2013 in Hangzhou, China. METHODS:A total of 2689 female and 2336 male patients with various genital symptoms were included in this study. Speci...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2014-202248
更新日期:2014-09-01 00:00:00
abstract::Expression profiling has been extensively applied to the study of breast cancer and undoubtedly is changing the way breast cancer is perceived. Over the past few years, several groups have described prognostic "signatures" (gene lists) that are purported to be more accurate prognostic factors than well established cli...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2005.028324
更新日期:2006-03-01 00:00:00
abstract::The thyroids of primary thyrotoxicosis patients prepared for partial thyroidectomy with propranolol contained much more lymphoid infiltrate than those prepared with carbimazole. No relation was found between the extent of lymphoid infiltrate in the thyroid and the development of postoperative hypothyroidism either bet...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.5.398
更新日期:1976-05-01 00:00:00
abstract:AIMS:Epidermal growth factor receptor (EGFR) T790M mutations can be detected in the circulating tumour DNA from plasma of patients with non-small cell lung cancer (NSCLC) to triage patients for osimertinib eligibility and monitor patients longitudinally for development of T790M-mediated resistance. METHODS:Using dropl...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206668
更新日期:2021-02-01 00:00:00
abstract:AIMS:Congenital neutropenia (CN) is a rare inherited disease that results in recurrent, life-threatening bacterial infections due to a deficiency of mature neutrophils. They are usually caused by heterozygous ELANE mutations although mutations in other genes like HAX-1, G6PC3 and GFI1 have also been reported. Identifyi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2019-206306
更新日期:2020-06-01 00:00:00
abstract:AIMS:The Royal College of Pathologists recommend that a median of at least 12 lymph nodes should be harvested during pathological staging of colorectal cancer. It is not always easy to harvest the required number, especially in patients with rectal cancer receiving neoadjuvant therapy. Lymph node revealing solutions, f...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-203281
更新日期:2016-06-01 00:00:00
abstract:AIMS:We aimed to study epidermal growth factor receptor (EGFR) expression in surgically resected pancreatic ductal adenocarcinomas (PDACs) by immunohistochemistry and their relationship to clinicopathological features, cell proliferation and cell adhesion protein expression. METHODS:A total of 99 PDACs were analysed o...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2013-201662
更新日期:2014-04-01 00:00:00