Abstract:
:The aim of the study was to investigate the subacute toxicity of a polychlorinated naphthalene (PCN) mixture and its effect on cytochrome P-450 levels in rats. The animals were administered PCNs intragastrically in repeated daily doses of 1, 10, and 100 mg/kg. The animals were dissected after 7, 14, or 21 doses. Doses of 10 and 100 mg/kg induced a significant decrease in the body weight at all time points of the experiment compared with the control group. The exposure to PCNs increased both the level of total cytochrome P-450 and the activity of CYP 1A at the same time points. In the groups of rats given PCNs in doses of 10 and 100 mg/kg, an evident dose- and time-dependent increase in malondialdehyde (MDA) level was observed throughout the experiment. The correlation between the increased MDA and decreased glutathione (GSH) levels in the liver was also observed.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Kilanowicz A,Skrzypinska-Gawrysiak M,Sapota A,Galoch A,Daragó Adoi
10.1016/j.ecoenv.2008.07.010subject
Has Abstractpub_date
2009-02-01 00:00:00pages
650-7issue
2eissn
0147-6513issn
1090-2414pii
S0147-6513(08)00185-1journal_volume
72pub_type
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