Pervasive sex-linked effects on transcription regulation as revealed by expression quantitative trait loci mapping in lake whitefish species pairs (Coregonus sp., Salmonidae).

abstract：:Transcriptional silencing in the budding yeast Saccharomyces cerevisiae may be linked to DNA replication and cell cycle progression. In this study, we have surveyed the effect of 41 mutations in genes with a role in replication, the cell cycle, and DNA repair on silencing at HMR. Mutations in PCNA (POL30), RF-C (CDC44...

journal_title：Genetics

authors： Ehrenhofer-Murray AE,Kamakaka RT,Rine J

更新日期：1999-11-01 00:00:00

abstract：:The identity of a given cell type is determined by the expression of a set of genes sharing common cis-regulatory motifs and being regulated by shared transcription factors. Here, we identify cis and trans regulatory elements that drive gene expression in the bilateral sensory neuron ASJ, located in the head of the ne...

journal_title：Genetics

authors： González-Barrios M,Fierro-González JC,Krpelanova E,Mora-Lorca JA,Pedrajas JR,Peñate X,Chavez S,Swoboda P,Jansen G,Miranda-Vizuete A

更新日期：2015-05-01 00:00:00

abstract：:The DNMT1 cytosine methyltransferase enzyme contains a large ∼300-aa intrinsically disordered domain (IDD) that we previously showed regulated DNA methylation patterns in mouse ES cells. Here we generated seven mouse lines with different mutations in the IDD. Homozygous mutant mice of five lines developed normally, wi...

journal_title：Genetics

authors： Shaffer B,McGraw S,Xiao SC,Chan D,Trasler J,Chaillet JR

更新日期：2015-02-01 00:00:00

abstract：:Evolution of a multigene family is studied from the standpoint of population genetics. It is assumed that the multigene family is undergoing continuous interchromosomal unequal crossing over, mutation and random frequency drift. The equilibrium properties of the probability of gene identity (clonality) are investigate...

journal_title：Genetics

authors： Ohta T

更新日期：1979-03-01 00:00:00

abstract：:About 450 black rats (Rattus rattus) were collected from 25 localities in Asia and Oceania. Their serum transferrins were analyzed by a newly developed thin layer acrylamide gel electrophoresis accompanied with acrinol pretreatment, exhibiting 12 transferrin bands. Generally, Asian type rats (2N=42) had fast-moving tr...

journal_title：Genetics

authors： Moriwaki K,Kato H,ImalH,Tsuchiya K,Yosida T

更新日期：1975-02-01 00:00:00

abstract：:The ade6-M26 mutation of Schizosaccharomyces pombe has previously been reported to stimulate ade6 intragenic meiotic recombination. We report here that the ade6-M26 mutation is a single G----T nucleotide change, that M26 stimulated recombination within ade6 but not at other distinct loci, and that M26 stimulated meiot...

journal_title：Genetics

authors： Ponticelli AS,Sena EP,Smith GR

更新日期：1988-07-01 00:00:00

abstract：:Host variation in Toll-like receptors and other innate immune signaling molecules alters infection susceptibility. However, only a portion of the variability observed in the innate immune response is accounted for by known genes in these pathways. Thus, the identification of additional genes that regulate the response...

journal_title：Genetics

authors： Alper S,Warg LA,De Arras L,Flatley BR,Davidson EJ,Adams J,Smith K,Wohlford-Lenane CL,McCray PB Jr,Pedersen BS,Schwartz DA,Yang IV

更新日期：2016-09-01 00:00:00

abstract：:A consensus map for loblolly pine (Pinus taeda L.) was constructed from the integration of linkage data from two unrelated three-generation outbred pedigrees. The progeny segregation data from restriction fragment length polymorphism, random amplified polymorphic DNA, and isozyme genetic markers from each pedigree wer...

journal_title：Genetics

authors： Sewell MM,Sherman BK,Neale DB

更新日期：1999-01-01 00:00:00

abstract：:The maize r locus encodes a transcription factor that regulates the developmental expression of the plant pigment anthocyanin. In an unusual example of gene regulatory diversity, the R-sc (Sc, strong seed color) and the R-p (P, plant color) alleles of r have nonoverlapping tissue specificity and nonhomologous 5' flank...

journal_title：Genetics

authors： Li Y,Bernot JP,Illingworth C,Lison W,Bernot KM,Eggleston WB,Fogle KJ,DiPaola JE,Kermicle J,Alleman M

更新日期：2001-12-01 00:00:00

abstract：:Caenorhabditis elegans' behavioral states, like those of other animals, are shaped by its immediate environment, its past experiences, and by internal factors. We here review the literature on C. elegans behavioral states and their regulation. We discuss dwelling and roaming, local and global search, mate finding, sle...

journal_title：Genetics

authors： Flavell SW,Raizen DM,You YJ

更新日期：2020-10-01 00:00:00

abstract：:Hairpin-tail (T(hp)) is a new allele of brachyury on chromosome 17 (linkage group IX) of the mouse. The morphological effects in the heterozygote are on the notochord and the tail. The homozygous abnormal is unknown. T(hp) is unique in that the phenotype of the heterozygote seems to depend on the source of the T(hp) g...

journal_title：Genetics

authors： JOHNSON DR

更新日期：1974-04-01 00:00:00

abstract：:Mutations were induced in synchronous Chinese hamster cells by bromodeoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle. There was a very pronounced temporal dependence during the first half of the DNA synthesis period for the induction of damage leading to 6-thioguanine (6TG) and ouabai...

journal_title：Genetics

authors： Burki HJ,Aebersold PM

更新日期：1978-10-01 00:00:00

abstract：:To identify hypothesized missing components of the synaptic G alpha(o)-G alpha(q) signaling network, which tightly regulates neurotransmitter release, we undertook two large forward genetic screens in the model organism C. elegans and focused first on mutations that strongly rescue the paralysis of ric-8(md303) reduct...

journal_title：Genetics

authors： Schade MA,Reynolds NK,Dollins CM,Miller KG

更新日期：2005-02-01 00:00:00

abstract：:The presence of at least ten mouse LDH-A pseudogenes was demonstrated in the genomic blot analysis, and four different processed pseudogenes have thus far been isolated and characterized. In this report, the nucleotide sequences to two different mouse lactate dehydrogenase-A processed pseudogenes, M11 and M14, were de...

journal_title：Genetics

authors： Fukasawa KM,Tanimura M,Sakai I,Sharief FS,Chung FZ,Li SS

更新日期：1987-01-01 00:00:00

abstract：:Obtaining accurate estimates of the genetic covariance matrix Sigma(G) for multivariate data is a fundamental task in quantitative genetics and important for both evolutionary biologists and plant or animal breeders. Classical methods for estimating Sigma(G) are well known to suffer from substantial sampling errors; i...

journal_title：Genetics

authors： Meyer K,Kirkpatrick M

更新日期：2010-07-01 00:00:00

abstract：:The extent of mtDNA length variation and heteroplasmy as well as DNA sequences of the control region and two tRNA genes were determined for four North American sturgeon species: Acipenser transmontanus, A. medirostris, A. fulvescens and A. oxyrhnychus. Across the Continental Divide, a division in the occurrence of len...

journal_title：Genetics

authors： Brown JR,Beckenbach K,Beckenbach AT,Smith MJ

更新日期：1996-02-01 00:00:00

abstract：:The Mus101 family of chromosomal proteins, identified initially in Drosophila, is widely conserved and has been shown to function in a variety of DNA metabolic processes. Such functions include DNA replication, DNA damage repair, postreplication repair, damage checkpoint activation, chromosome stability, and chromosom...

journal_title：Genetics

authors： Holway AH,Hung C,Michael WM

更新日期：2005-03-01 00:00:00

abstract：:We present a two-layer hidden Markov model to detect the structure of haplotypes for unrelated individuals. This allows us to model two scales of linkage disequilibrium (one within a group of haplotypes and one between groups), thereby taking advantage of rich haplotype information to infer local ancestry of admixed i...

journal_title：Genetics

authors： Guan Y

更新日期：2014-03-01 00:00:00

abstract：:We found that heterozygous mutant alleles of E(Pc) and esc increased homologous recombination from an allelic template in somatic cells in a P-element-induced double-strand break repair assay. Flies heterozygous for mutant alleles of these genes showed increased genome stability and decreased levels of apoptosis in im...

journal_title：Genetics

authors： Holmes AM,Weedmark KA,Gloor GB

更新日期：2006-04-01 00:00:00

abstract：:pep5 mutants of Saccharomyces cerevisiae accumulate inactive precursors to the vacuolar hydrolases. The PEP5 gene was isolated from a genomic DNA library by complementation of the pep5-8 mutation. Deletion analysis localized the complementing activity to a 3.3-kb DNA fragment. DNA sequence analysis of the PEP5 gene re...

journal_title：Genetics

authors： Woolford CA,Dixon CK,Manolson MF,Wright R,Jones EW

更新日期：1990-08-01 00:00:00

abstract：:Gene expression in Anopheles gambiae shows a deficiency of testis-expressed genes on the X chromosome associated with an excessive movement of retrogene duplication. We suggest that the degeneration of sex chromosomes in this monandrous species is likely the result of pressures from X inactivation, dosage compensation...

journal_title：Genetics

authors： Baker DA,Russell S

更新日期：2011-11-01 00:00:00

abstract：:Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...

journal_title：Genetics

authors： Cutter AD,Agrawal AF

更新日期：2010-06-01 00:00:00

abstract：:Distance- as well as marker-dependence of genetic recombination of bacteriophage T4 was studied in crosses between rIIB mutants with known base sequences. The notion of a "basic recombination," which is the recombination within distances shorter than hybrid DNA length in the absence of mismatch repair and any marker e...

journal_title：Genetics

authors： Shcherbakov VP,Plugina LA

更新日期：1991-08-01 00:00:00

abstract：:Penicillium marneffei is an opportunistic fungal pathogen of humans and the only dimorphic species identified in its genus. At 25 degrees P. marneffei exhibits true filamentous growth, while at 37 degrees P. marneffei undergoes a dimorphic transition to produce uninucleate yeast cells that divide by fission. Members o...

journal_title：Genetics

authors： Borneman AR,Hynes MJ,Andrianopoulos A

更新日期：2001-03-01 00:00:00

abstract：:A novel fine structure mapping method for quantitative traits is presented. It is based on Bayesian modeling and inference, treating the number of quantitative trait loci (QTLs) as an unobserved random variable and using ideas similar to composite interval mapping to account for the effects of QTLs in other chromosome...

journal_title：Genetics

authors： Sillanpää MJ,Arjas E

更新日期：1998-03-01 00:00:00

abstract：:The process of close recombinant formation in bacteriophage T5 crosses has been studied by examining the structure of internal heterozygotes (HETs), the immediate products of recombination events. The T5 system was chosen because it permits the study of internal heterozygotes exclusively, thus avoiding the ambiguities...

journal_title：Genetics

authors： Beck BN

更新日期：1980-09-01 00:00:00

abstract：:Among a large number of homologous gene clusters in C. elegans, two gene families that appear to undergo concerted evolution were studied in detail. Both gene families are nematode specific and encode small secreted proteins of unknown function. For both families in three Caenorhabditis species, concerted groups of ge...

journal_title：Genetics

authors： Thomas JH

更新日期：2006-04-01 00:00:00

abstract：:A variety of Saccharomyces strains were examined for the presence of 2micro DNA and, if present, for the pattern of fragments produced by its digestion with site-specific (restriction) endonucleases. Two strains were found that did not contain detectable levels of 2micro DNA, and two strains contained 2micro DNA molec...

journal_title：Genetics

authors： Livingston DM

更新日期：1977-05-01 00:00:00

abstract：:Tetrazolium oxidase from the blood and liver of rainbow trout was found to be genetically polymorphic. The inheritance pattern of the liver enzyme was compatible only with a one locus-two allele hypothesis. The enzymes in the blood while having an electrophoretically identical polymorphism could differ genotypically f...

journal_title：Genetics

authors： Cederbaum SD,Yoshida A

更新日期：1972-10-01 00:00:00

abstract：:The Polymerase Associated Factor 1 complex (Paf1C) is a multifunctional regulator of eukaryotic gene expression important for the coordination of transcription with chromatin modification and post-transcriptional processes. In this study, we investigated the extent to which the functions of Paf1C combine to regulate t...

journal_title：Genetics

authors： Ellison MA,Lederer AR,Warner MH,Mavrich TN,Raupach EA,Heisler LE,Nislow C,Lee MT,Arndt KM

更新日期：2019-07-01 00:00:00