The Groningen Longitudinal Glaucoma Study. II. A prospective comparison of frequency doubling perimetry, the GDx nerve fibre analyser and standard automated perimetry in glaucoma suspect patients.

Abstract:

PURPOSE:We aimed to determine prospectively the incidence of abnormal test results on frequency doubling perimetry (FDT), the nerve fibre analyser (GDx) and standard automated perimetry (SAP) in a cohort of glaucoma suspect patients with normal findings for all these tests at baseline. METHODS:Seventy glaucoma suspect patients were followed prospectively for 4 years with SAP (Humphrey field analyser 30-2 SITA Fast), FDT (C-20 full-threshold) and GDx (Version 2.010) in a clinical setting. All patients had normal baseline test results on SAP, FDT and GDx. After the follow-up period, the number of patients who converted (whose test results changed from normal at baseline to reproducibly abnormal during follow-up) were counted for each technique and then compared. The cut-off point for FDT was > 1 depressed test-point p < 0.01 in the total deviation probability plot; the cut-off point for GDx was the Number > 29. RESULTS:Of the 70 glaucoma suspect patients, three converted on FDT, 14 on GDx and six on SAP. These proportions are significantly different for GDx versus SAP (p = 0.033) and GDx versus FDT (p = 0.002), but not for FDT versus SAP (p = 0.256). CONCLUSIONS:The most frequent finding after a 4-year follow-up was conversion on GDx.

journal_name

Acta Ophthalmol

journal_title

Acta ophthalmologica

authors

Jansonius NM,Heeg GP

doi

10.1111/j.1755-3768.2008.01279.x

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

429-32

issue

4

eissn

1755-375X

issn

1755-3768

pii

AOS1279

journal_volume

87

pub_type

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