当前位置： SCI文献检索 > TOXICOLOGY LETTERS期刊下所有文献 > Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats.

Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats.

Abstract：

:Polycyclic aromatic hydrocarbons (PAHs) are an important group of environmental pollutants, known for their mutagenic and carcinogenic activities. Many PAHs are aryl hydrocarbon receptor (AhR) ligands and several recent studies have suggested that PAHs or their metabolites may activate estrogen receptors (ER). The present study investigated possible estrogenic/antiestrogenic effects of abundant environmental contaminants benzo[a]pyrene (BaP), benz[a]anthracene (BaA), fluoranthene (Fla) and benzo[k]fluoranthene (BkF) in vivo, using the immature rat uterotrophic assay. The present results suggest that BaA, BaP and Fla behaved as estrogen-like compounds in immature Wistar rats, when applied for 3 consecutive days at 10mg/kg/day, as documented by a significant increase of uterine weight and hypertrophy of luminal epithelium. These effects were likely to be mediated by ERalpha, a major subtype of ER present in uterus, as they were inhibited by treatment with ER antagonist ICI 182,780. BaA, the most potent of studied PAHs, induced a significant estrogenic effect within a concentration range 0.1-50mg/kg/day; however, it did not reach the maximum level induced by reference estrogens. The proposed antiestrogenicity of the potent AhR agonist BkF was not confirmed in the present in vivo study; the exposure to BkF did not significantly affect the uterine weight, although a weak suppression of ERalpha immunostaining was observed in luminal and glandular epithelium, possibly related to its AhR-mediated activity. The PAHs under study did not induce marked genotoxic damage in uterine tissues, as documented by the lack of Ser-15-phoshorylated p53 protein staining. With the exception of Fla, all three remaining compounds increased CYP1-dependent monooxygenation activities in liver at the doses used, suggesting that the potential tissue-specific antiestrogenic effects of PAHs mediated by metabolization of 17beta-estradiol also cannot be excluded. Taken together, these environmentally relevant PAHs induced estrogenic effects in vivo, which might affect their toxic impact and carcinogenicity.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Kummer V,Masková J,Zralý Z,Neca J,Simecková P,Vondrácek J,Machala M

doi

10.1016/j.toxlet.2008.06.862

subject

Has Abstract

pub_date

2008-08-28 00:00:00

pages

212-21

issue

3

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(08)01040-0

journal_volume

180

pub_type

杂志文章

相关文献

TOXICOLOGY LETTERS文献大全
  • Correlation between the DNA-binding affinity of topoisomerase inhibiting drugs and their capacity to induce hematopoetic cell differentiation.

    abstract：:There is accumulating evidence that both type I and type II DNA-topoisomerases play a key role in cellular differentiation. Human HL-60 leukemia cells can be induced to monocytic or granulocytic differentiation with various compounds; amongst them camptothecin, a topoisomerase I inhibitor and VP-16, VM-26 and mitoxant...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(93)90066-7

    authors： Gieseler F,Boege F,Clark M,Meyer P

    更新日期：1993-04-01 00:00:00

  • Binding interactions of halogenated bisphenol A with mouse PPARα: In vitro investigation and molecular dynamics simulation.

    abstract：:The binding of bisphenol A (BPA) and its halogenated derivatives (halogenated BPAs) to mouse peroxisome proliferator-activated receptor α ligand binding domain (mPPARα-LBD) was examined by a combination of in vitro investigation and in silico simulation. Fluorescence polarization (FP) assay showed that halogenated BPA...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2017.11.004

    authors： Zhang J,Li T,Wang T,Guan T,Yu H,Li Z,Wang Y,Wang Y,Zhang T

    更新日期：2018-02-01 00:00:00

  • Pleural plaques in asbestosis: effect of Candida albicans.

    abstract：:Effect of chrysotile dust alone or together with Candida albicans administered intratracheally in guinea pigs was studied in the genesis of pleural plaques over a period of 12 months. A significant increase of mucopolysaccharides, phosphorus, calcium and -SH content was detected in pleural fluid of animals treated wit...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(82)90207-7

    authors： Saxena KC,Srivastava L,Ali S,Dogra RK

    更新日期：1982-10-01 00:00:00

  • Predictive testing for respiratory sensitisation.

    abstract：:A rat bioassay has been developed to provide an objective approach for the identification and classification of upper and lower respiratory tract irritants, with particular emphasis on the concentration-dependent induction and regression of lesions characteristic of asthma, such as persisting non-specific airway hyper...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/0378-4274(96)03688-0

    authors： Pauluhn J

    更新日期：1996-08-01 00:00:00

  • Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: a possible involvement of reactive oxygen species.

    abstract：:Pyrethroid pesticides are used preferably over organochlorines and organophosphates due to their high effectiveness, low toxicity to non-target organisms and easy biodegradibility. However, it is possible that during the pyrethroid metabolism, there is generation of reactive oxygen species (ROS) and pyrethroids may pr...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(98)00399-3

    authors： Kale M,Rathore N,John S,Bhatnagar D

    更新日期：1999-04-12 00:00:00

  • Effect of partial hepatectomy on hepatic metallothionein and glutathione levels and cadmium distribution in different tissues.

    abstract：:The changes in hepatic metallothionein (MT) and glutathione levels and cadmium distribution were investigated 72 hr after a subcutaneous administration of 1.5 mg Cd2+/kg as CdCl2H2O to normal and partially hepatectomized rats. Partial hepatectomy had no effect on native metallothionein content. Cadmium and MT content ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(82)90195-3

    authors： Asokan P

    更新日期：1982-06-01 00:00:00

  • Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness.

    abstract：:Oxime-based acetylcholinesterase reactivators (briefly oximes) regenerate organophosphate-inactivated acetylcholinesterase and restore its function. Poor blood-brain-barrier passage and fast elimination from blood limit their actual use in treatment of patients exposed to organophosphates. Previous in vitro results im...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2019.11.021

    authors： Zdarova Karasova J,Hepnarova V,Andrys R,Lisa M,Jost P,Muckova L,Pejchal J,Herman D,Jun D,Kassa J,Kuca K

    更新日期：2020-03-01 00:00:00

  • HIV-1 antiretrovirals induce oxidant injury and increase intima-media thickness in an atherogenic mouse model.

    abstract：:A growing body of evidence suggests HIV patients are at a greater risk for developing atherosclerosis. However, clinical investigations have generated conflicting results with regard to whether antiretrovirals are independently involved in the development of HIV-associated atherosclerosis. By administering antiretrovi...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2009.02.017

    authors： Jiang B,Hebert VY,Khandelwal AR,Stokes KY,Dugas TR

    更新日期：2009-06-22 00:00:00

  • Recent developments in methanol toxicity.

    abstract：:The disposition of methanol and its putative toxic metabolite formate has been studied in humans, non-human primates, and rodents after exposure to high, neurotoxic doses. The rate at which rodents detoxify formate is more rapid than that of primates. Formate, an endogenous biological substrate, is detoxified by metab...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/0378-4274(95)03515-x

    authors： Medinsky MA,Dorman DC

    更新日期：1995-12-01 00:00:00

  • Furan is not genotoxic in the micronucleus assay in vivo or in vitro.

    abstract：:Furan, a potential human carcinogen, is formed during heat-treatment of food. Previous studies of the genotoxicity of furan have given disparate results. Hence, there is a need for complementary data to clarify the mechanism behind the carcinogenicity of furan. In this study, we have used the flow cytometer-based micr...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2006.08.020

    authors： Durling LJ,Svensson K,Abramsson-Zetterberg L

    更新日期：2007-02-28 00:00:00

  • Classification of chemicals as sensitisers based on new test methods.

    abstract：:For the last decade, classification schemes worldwide have recognised that certain chemicals may need to be categorised as skin or respiratory sensitisers. Although differing in detail, the schemes use similar criteria for designating materials as sensitisers, based on either direct evidence from exposed humans or the...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/0378-4274(92)90186-n

    authors： Botham PA

    更新日期：1992-12-01 00:00:00

  • Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells.

    abstract：:Autophagy, which works to remove stress and maintain cellular homeostasis, is usually considered a "pro-survival" signal. Contrarily, apoptosis is programmed "pro-death" machinery. Polychlorinated biphenyls (PCBs) are a group of ubiquitous industrial pollutants. Our previous studies illustrated that a PCB quinone meta...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2019.02.002

    authors： Shi Q,Wang Y,Dong W,Song E,Song Y

    更新日期：2019-05-15 00:00:00

  • Nicotine and neurodegeneration in ageing.

    abstract：:Impairment in cholinergic systems is a highly consistent finding in human dementia. Among cholinergic markers, marked decreases in nicotine binding have been most consistently observed in the telencephalic regions of demented patients and are thought to contribute to the cognitive deficits associated with ageing and a...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-4274(01)00502-1

    authors： Zanardi A,Leo G,Biagini G,Zoli M

    更新日期：2002-02-28 00:00:00

  • Effects of 4-hydroxynonenal and N-acetyl-L-cysteine on Myc-induced apoptosis.

    abstract：:Apoptosis has been described as programmed active cell death. Overexpression of the c-Myc gene has been shown to induce apoptosis in Rat1A/Myc-ER cells when combined with a growth blocking agent. In the present study, we tested whether 4-Hydroxynonenal (HNE) or N-acetyl-L-cysteine (LNAC) affect apoptotic death in seru...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(96)03816-7

    authors： Yildiz D,Erçal N,Frank RL,Matthews RH

    更新日期：1996-12-31 00:00:00

  • Importance of species selection in drug toxicity testing.

    abstract：:The development of efficacious and safe new human pharmaceuticals continues to be highly dependent on well-designed and carefully executed animal toxicology studies. Although the protocols of most toxicology studies now conform to a standard format, careful selection of the most appropriate and relevant laboratory spe...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(98)00263-x

    authors： Morton DM

    更新日期：1998-12-28 00:00:00

  • Prenatal administration of indomethacin modulates Th2 cytokines in juvenile rats.

    abstract：:Indomethacin (IND) suppresses the T-dependent antibody response (TDAR) in juvenile males when it is administered to pregnant rats during late gestation. In this study, the effect of IND on cytokine production in juvenile rats was examined to investigate the mechanism behind the suppression of antibody production. IND ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2008.11.013

    authors： Kushima K,Sakuma S,Furusawa S,Fujiwara M

    更新日期：2009-02-25 00:00:00

  • Biochemical, pathologic and morphometric alterations induced in male B6C3F1 mouse liver by short-term exposure to dichloroacetic acid.

    abstract：:Dichloroacetic acid (DCA) is a complete hepatocarcinogen and tumor promoter in the male B6C3F1 mouse. Published reports indicate that the compound is non-genotoxic. This study examines possible non-genotoxic (epigenetic) mechanisms by which DCA elicits its carcinogenic response. Correlative biochemical, pathologic and...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(95)03409-9

    authors： Carter JH,Carter HW,DeAngelo AB

    更新日期：1995-11-01 00:00:00

  • Effects of sulfur mustard on mesenchymal stem cells.

    abstract：:Chronic wound healing disorders that occur as a result of a sulfur mustard (SM) exposure present a particular challenge. These chronic wounds are similar to other chronic wounds. In the past, it has been shown that mesenchymal stem cells (MSC) play an important role in the healing of chronic wounds. An important prope...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2017.08.008

    authors： Schmidt A,Steinritz D,Rothmiller S,Thiermann H,Scherer AM

    更新日期：2018-09-01 00:00:00

  • Progress in understanding adjuvant immunotoxicity mechanisms.

    abstract：:Over the last twenty years research has provided an important insight into the mechanisms responsible for the immunotoxicity of both local and systemic adverse reactions following the use of immunostimulating drugs and adjuvants. In this article we provide an update of the present knowledge relating to the various par...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.toxlet.2011.03.001

    authors： Batista-Duharte A,Lindblad EB,Oviedo-Orta E

    更新日期：2011-06-10 00:00:00

  • d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions.

    abstract：:Cataract is the leading cause of blindness with an estimated 16 million people affected worldwide. d-galactose (d-gal) is a reducing sugar that widely distributed in foodstuffs, and studies show that d-gal could promote cataract formation by damaging nature lens epithelial cells (LECs). However, the underlying mechani...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2018.02.001

    authors： Xu Y,Li Y,Ma L,Xin G,Wei Z,Zeng Z,Xing Z,Li S,Niu H,Huang W

    更新日期：2018-06-01 00:00:00

  • Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice.

    abstract：:Furocoumarins are a group of natural products with many biological activities. Clinical evidences have demonstrated the important contribution of furocoumarins to the toxicity of some foods and herbs. In order to assess liver and kidney toxicity of furocoumarins, male mice were orally administrated with psoralen, isop...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2011.11.030

    authors： Wang X,Lou YJ,Wang MX,Shi YW,Xu HX,Kong LD

    更新日期：2012-02-25 00:00:00

  • Reductive activation of HCFC-123 by methaemalbumin.

    abstract：:Hydrochlorofluorocarbon 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), a close structural analogue of the hepatotoxic anaesthetic halotane and a replacement for some ozone-depleting chlorofluorocarbons, is metabolized by liver cytochrome P450 (P450), both in vitro and in vivo. P450 activates HCFC-123, both oxidatively...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(03)00232-7

    authors： Zanovello A,Ferrara R,Manno M

    更新日期：2003-09-15 00:00:00

  • Effect of acute and repeated chlordimeform treatment on rat hepatic microsomal drug metabolizing enzymes.

    abstract：:The effect of chlordimeform (CDM) treatment on the hepatic microsomal drug metabolizing enzymes was examined in male and female rats following either acute or repeated treatment. After acute administration of chlordimeform (100 mg/kg, i.p., 1 hour before killing) differential effects were observed in various parameter...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(83)90072-3

    authors： Budris DM,Yim GK,Carlson GP,Schnell RC

    更新日期：1983-08-01 00:00:00

  • Toxic effects of mosquito coil (a mosquito repellent) smoke on rats. II. Morphological changes of the respiratory system.

    abstract：:A group of 20 female albino rats was exposed to mosquito coil smoke, 8 h a day, 6 days per week, for 60 days. An additional group receiving air exposure served as control. The smoke-exposed animals had a lower body weight than the controls. Smoke-induced histopathological lesions, including an inflammation of the trac...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(87)90238-4

    authors： Liu WK,Wong MH

    更新日期：1987-12-01 00:00:00

  • Tumor necrosis factor is involved in chlorpyrifos--induced changes in core temperature in the female rat.

    abstract：:Chlorpyrifos (CHP), an OP-based pesticide, induces hypothermia in the rat followed by a fever that persists for several days. The cytokine, tumor necrosis factor-alpha (TNF), is induced by lipopolysaccharide (LPS) and released during fever and has both pyrogenic and cryogenic (i.e. antipyretic) properties. Administeri...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(99)00122-8

    authors： Rowsey PJ,Gordon CJ

    更新日期：1999-09-20 00:00:00

  • Low doses of individual and combined deoxynivalenol and zearalenone in naturally moldy diets impair intestinal functions via inducing inflammation and disrupting epithelial barrier in the intestine of piglets.

    abstract：:The intestinal epithelium is the first barrier against food contaminants and is highly sensitive to Fusarium toxins, especially deoxynivalenol (DON) and zearalenone (ZEA). Here, we explored the effects of low doses of DON and/or ZEA in naturally moldy diets on intestinal functions in piglets, including inflammatory re...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2020.07.032

    authors： Jia R,Liu W,Zhao L,Cao L,Shen Z

    更新日期：2020-10-15 00:00:00

  • Convergence of air pollutant-induced redox-sensitive signals in the dendritic cells contributes to asthma pathogenesis.

    abstract：:Exposure to airborne particulate matter (PM) is a major risk factor for allergic airway inflammation such as asthma. Many of the PM components (i.e., polycyclic aromatic hydrocarbons and metals) are redox-active and capable of inducing cellular oxidative stress and injuries including inflammation and cell death. Airwa...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.toxlet.2015.05.017

    authors： Li N,Buglak N

    更新日期：2015-08-19 00:00:00

  • Role of inflammation in chemical-induced hepatotoxicity.

    abstract：:The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseas...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-4274(01)00284-3

    authors： Luster MI,Simeonova PP,Gallucci RM,Bruccoleri A,Blazka ME,Yucesoy B

    更新日期：2001-03-31 00:00:00

  • Circulating microRNA profiles altered in mice after 28 d exposure to perfluorooctanoic acid.

    abstract：:Perfluorooctanoic acid (PFOA) is a stable man-made compound with many industrial and commercial uses. Recently, however, concern has been raised that it may induce various toxicological effects such as hepatotoxicity, immunotoxicity, and developmental toxicity. Because levels of circulating microRNAs (miRNAs) can be a...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2013.10.017

    authors： Yan S,Wang J,Zhang W,Dai J

    更新日期：2014-01-03 00:00:00

  • Poly-l-aspartic acid protects cultured human proximal tubule cells against aminoglycoside-induced electrophysiological alterations.

    abstract：:Cultured human proximal tubule cell monolayers maintained on permeable supports were treated simultaneously with the aminoglycoside antibiotic, gentamicin, and poly-L-aspartic acid (PAA), an inhibitor of aminoglycoside nephrotoxicity. Following 4 days of exposure, cell monolayers were placed into Ussing chambers to al...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(96)03858-1

    authors： Todd JH,Hottendorf GH

    更新日期：1997-02-07 00:00:00