Fatal intoxication with milnacipran.

Abstract:

:The antidepressant milnacipran is a double serotonin/noradrenalin reuptake inhibitor. The low reported incidence of intoxication indicates excellent tolerance in comparison with tricyclic and second generation antidepressants. We report a fatal intoxication associating milnacipran, at blood levels (femoral=21.5 mg/l, cardiac=20 mg/l) 40-fold higher than the usual treatment concentration, and six other molecules (fluoxetine, norfluoxetine, sertraline, cyamemazine, nordazepam and oxazepam) at therapeutic levels. To the best of our knowledge, this is the first reported fatal intoxication involving milnacipran.

journal_name

J Forensic Leg Med

authors

Fanton L,Bévalot F,Grait H,Le Meur C,Gaillard Y,Malicier D

doi

10.1016/j.jflm.2007.12.006

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

388-90

issue

6

eissn

1752-928X

issn

1878-7487

pii

S1752-928X(07)00193-X

journal_volume

15

pub_type

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