Abstract：
BACKGROUND:Escherichia coli is the commonest cause of community and nosocomial urinary tract infection (UTI). Antibiotic treatment is usually empirical relying on susceptibility data from local surveillance studies. We therefore set out to determine levels of resistance to 8 commonly used antimicrobial agents amongst all urinary isolates obtained over a 12 month period. METHODS:Antimicrobial susceptibility to ampicillin, amoxicillin/clavulanate, cefalexin, ciprofloxacin, gentamicin, nitrofurantoin, trimethoprim and cefpodoxime was determined for 11,865 E. coli urinary isolates obtained from community and hospitalised patients in East London. RESULTS:Nitrofurantoin was the most active agent (94% susceptible), followed by gentamicin and cefpodoxime. High rates of resistance to ampicillin (55%) and trimethoprim (40%), often in combination were observed in both sets of isolates. Although isolates exhibiting resistance to multiple drug classes were rare, resistance to cefpodoxime, indicative of Extended spectrum beta-lactamase production, was observed in 5.7% of community and 21.6% of nosocomial isolates. CONCLUSION:With the exception of nitrofurantoin, resistance to agents commonly used as empirical oral treatments for UTI was extremely high. Levels of resistance to trimethoprim and ampicillin render them unsuitable for empirical use. Continued surveillance and investigation of other oral agents for treatment of UTI in the community is required.
journal_name
Ann Clin Microbiol Antimicrobjournal_title
Annals of clinical microbiology and antimicrobialsauthors
Bean DC,Krahe D,Wareham DWdoi
10.1186/1476-0711-7-13subject
Has Abstractpub_date
2008-06-18 00:00:00pages
13issn
1476-0711pii
1476-0711-7-13journal_volume
7pub_type
杂志文章abstract：BACKGROUND:Accurate identification of isolates belonging to genus Enterococcus, Streptococcus, coagulase-negative Staphylococcus, and Lactococcus at the species level is necessary to provide a better understanding of their pathogenic potential, to aid in making clinical decisions, and to conduct epidemiologic investiga...
journal_title：Annals of clinical microbiology and antimicrobials
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journal_title：Annals of clinical microbiology and antimicrobials
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journal_title：Annals of clinical microbiology and antimicrobials
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pub_type： 杂志文章,随机对照试验
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journal_title：Annals of clinical microbiology and antimicrobials
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journal_title：Annals of clinical microbiology and antimicrobials
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journal_title：Annals of clinical microbiology and antimicrobials
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journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
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journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-9-5
更新日期：2010-01-22 00:00:00
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