Macrophages, more than just scavengers: their role in breast development and cancer.

Abstract:

:Macrophages, derived from circulating monocytes, are located within virtually all adult tissues. There, these specialized cells adopt tissue-specific functions that are important for normal tissue homeostasis and response to physiological challenges. Increasing evidence suggests that macrophages play a role in the normal development of certain organs, such as the breast. Intriguingly, macrophages are often found in the stroma of breast tumours, where they may promote tumour growth and metastasis. In this review we discuss this emerging area of developmental and tumour biology.

journal_name

ANZ J Surg

journal_title

ANZ journal of surgery

authors

Gyorki DE,Lindeman GJ

doi

10.1111/j.1445-2197.2008.04531.x

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

432-6

issue

6

eissn

1445-1433

issn

1445-2197

pii

ANS4531

journal_volume

78

pub_type

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