Linear mucosal defect may be characteristic of lansoprazole-associated collagenous colitis.

Abstract:

BACKGROUND:Although some cases of collagenous colitis have been induced by lansoprazole (LPZ), the clinicopathologic features of LPZ-associated collagenous colitis have not been elucidated. OBJECTIVE:To elucidate the clinical, endoscopic, and histopathologic features of LPZ-associated collagenous colitis. DESIGN:Retrospective case study. PATIENTS:The subjects were 13 patients with collagenous colitis diagnosed during a period from 2002 to 2007. MAIN OUTCOME MEASUREMENTS:The colonoscopic and histopathologic findings were compared retrospectively between 9 cases of LPZ use (LPZ group) and 4 cases without the use of LPZ (non-LPZ group). RESULTS:A colonoscopy revealed a linear mucosal defect more frequently in the LPZ group (7 of 9 cases [78%]) than in the non-LPZ group (0 of 4 cases [0%], P = .02). Friable mucosa was also noted in 4 patients (44%) in the LPZ group but none in the non-LPZ group. The colonoscopic finding in the non-LPZ group was either normal mucosa or nonspecific minimal abnormalities, whereas patients in the LPZ group had either a linear mucosal defect, mucosal bleeding, or both (P = .001). On histologic examination, the subepithelial collagen band was thicker in patients in the LPZ group than in those in the non-LPZ group (median 45 vs 26.3 mum). All patients in the LPZ group recovered from diarrhea after discontinuance of LPZ. LIMITATION:A small number of patients. CONCLUSIONS:Linear mucosal defects and friable mucosa may be characteristic colonoscopic findings in cases of LPZ-associated collagenous colitis.

journal_name

Gastrointest Endosc

authors

Umeno J,Matsumoto T,Nakamura S,Jo Y,Yada S,Hirakawa K,Yoshimura R,Yamagata H,Kudo T,Hirano A,Gushima M,Yao T,Nakashima Y,Iida M

doi

10.1016/j.gie.2008.02.013

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

1185-91

issue

7

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(08)00213-7

journal_volume

67

pub_type

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