Evolutionary origin of regulatory regions of retrogenes in Drosophila.

abstract：BACKGROUND:Human T cell leukemia virus type 1 (HTLV-1) Tax is a potent activator of viral and cellular gene expression that interacts with a number of cellular proteins. Many reports show that Tax is capable of regulating cell cycle progression and apoptosis both positively and negatively. However, it still remains to ...

journal_title：BMC genomics

authors： Arainga M,Murakami H,Aida Y

更新日期：2012-06-22 00:00:00

abstract：BACKGROUND:There is a large amount of inconsistency in gene structure annotations of bacterial strains. This inconsistency is a frustrating impedance to effective comparative genomic analysis of bacterial strains in promising applications such as gaining insights into bacterial drug resistance. RESULTS:Here, we propos...

journal_title：BMC genomics

authors： Wozniak M,Wong L,Tiuryn J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Adult neurogenesis, which is the continual production of new neurons in the mature brain, demonstrates the strikingly plastic nature of the nervous system. Adult neural stem cells and their neural precursors, collectively referred to as neural progenitor cells (NPCs), are present in the subgranular zone (SGZ...

journal_title：BMC genomics

authors： Poon A,Goldowitz D

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Prokaryotic translation initiation involves the proper docking, anchoring, and accommodation of mRNA to the 30S ribosomal subunit. Three initiation factors (IF1, IF2, and IF3) and some ribosomal proteins mediate the assembly and activation of the translation initiation complex. Although the interaction betwe...

journal_title：BMC genomics

authors： Omotajo D,Tate T,Cho H,Choudhary M

更新日期：2015-08-14 00:00:00

abstract：BACKGROUND:Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT). RESULTS:We analyzed the postnatal transformation of adipose in sheep with a time course study of the ...

journal_title：BMC genomics

authors： Basse AL,Dixen K,Yadav R,Tygesen MP,Qvortrup K,Kristiansen K,Quistorff B,Gupta R,Wang J,Hansen JB

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:NOD26-like intrinsic proteins (NIPs) that belong to the aquaporin superfamily are plant-specific and exhibit a similar three-dimensional structure. Experimental evidences however revealed that functional divergence should have extensively occurred among NIP genes. It is therefore intriguing to further invest...

journal_title：BMC genomics

authors： Liu Q,Wang H,Zhang Z,Wu J,Feng Y,Zhu Z

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:The occurrence of liver cancer is higher in males than in females, and the incidence increases during aging. Signaling pathways regulated by retinoid x receptor alpha (RXRalpha) are involved in hepatocellular carcinogenesis. The phenotype of hepatocyte RXRalpha deficient mice is different between genders. To...

journal_title：BMC genomics

authors： Guo M,Gong L,He L,Lehman-McKeeman L,Wan YJ

更新日期：2008-08-28 00:00:00

abstract：BACKGROUND:Codon usage analysis has been a classical topic for decades and has significances for studies of evolution, mRNA translation, and new gene discovery, etc. While the codon usage varies among different members of the plant kingdom, indicating the necessity for species-specific study, this work has mostly been ...

journal_title：BMC genomics

authors： Feng C,Xu CJ,Wang Y,Liu WL,Yin XR,Li X,Chen M,Chen KS

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:The reconstruction of gene regulatory networks from high-throughput "omics" data has become a major goal in the modelling of living systems. Numerous approaches have been proposed, most of which attempt only "one-shot" reconstruction of the whole network with no intervention from the user, or offer only simp...

journal_title：BMC genomics

authors： Kadupitige SR,Leung KC,Sellmeier J,Sivieng J,Catchpoole DR,Bain ME,Gaëta BA

更新日期：2009-12-03 00:00:00

abstract：BACKGROUND:In a previous genome-wide analysis of FXR binding to hepatic chromatin, we noticed that an extra nuclear receptor (NR) half-site was co-enriched close to the FXR binding IR-1 elements and we provided limited support that the monomeric LRH-1 receptor that binds to NR half-sites might function together with FX...

journal_title：BMC genomics

authors： Chong HK,Biesinger J,Seo YK,Xie X,Osborne TF

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Spinal cord injury leads to neurological dysfunctions affecting the motor, sensory as well as the autonomic systems. Increased excitability of motor neurons has been implicated in injury-induced spasticity, where the reappearance of self-sustained plateau potentials in the absence of modulatory inputs from t...

journal_title：BMC genomics

authors： Ryge J,Winther O,Wienecke J,Sandelin A,Westerdahl AC,Hultborn H,Kiehn O

更新日期：2010-06-09 00:00:00

abstract：BACKGROUND:White spot syndrome (WSS) is a viral disease that affects most of the commercially important shrimps and causes serious economic losses to the shrimp farming industry worldwide. However, little information is available in terms of the molecular mechanisms of the host-virus interaction. In this study, we used...

journal_title：BMC genomics

authors： Leu JH,Chang CC,Wu JL,Hsu CW,Hirono I,Aoki T,Juan HF,Lo CF,Kou GH,Huang HC

更新日期：2007-05-16 00:00:00

abstract：BACKGROUND:Isatis indigotica is a widely used herb for the clinical treatment of colds, fever, and influenza in Traditional Chinese Medicine (TCM). Various structural classes of compounds have been identified as effective ingredients. However, little is known at genetics level about these active metabolites. In the pre...

journal_title：BMC genomics

authors： Chen J,Dong X,Li Q,Zhou X,Gao S,Chen R,Sun L,Zhang L,Chen W

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Candida albicans is an opportunistic pathogenic yeast, which could become pathogenic in various stressful environmental factors including the spaceflight environment. In this study, we aim to explore the phenotypic changes and possible mechanisms of C. albicans after exposure to spaceflight conditions. RESU...

journal_title：BMC genomics

authors： Wang J,Liu Y,Zhao G,Gao J,Liu J,Wu X,Xu C,Li Y

更新日期：2020-01-17 00:00:00

abstract：BACKGROUND:Sequencing data has become a standard measure of diverse cellular activities. For example, gene expression is accurately measured by RNA sequencing (RNA-Seq) libraries, protein-DNA interactions are captured by chromatin immunoprecipitation sequencing (ChIP-Seq), protein-RNA interactions by crosslinking immun...

journal_title：BMC genomics

authors： Kucukural A,Yukselen O,Ozata DM,Moore MJ,Garber M

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:In mammalian cells changes in intracellular pH (pHi), which are predominantly controlled by activity of plasma membrane ion exchangers, regulate a diverse range of normal and pathological cellular processes. How changes in pHi affect distinct cellular processes has primarily been determined by evaluating pro...

journal_title：BMC genomics

authors： Putney LK,Barber DL

更新日期：2004-07-16 00:00:00

abstract：BACKGROUND:The Zap1 transcription factor is a central player in the response of yeast to changes in zinc status. We previously used transcriptome profiling with DNA microarrays to identify 46 potential Zap1 target genes in the yeast genome. In this new study, we used complementary methods to identify additional Zap1 ta...

journal_title：BMC genomics

authors： Wu CY,Bird AJ,Chung LM,Newton MA,Winge DR,Eide DJ

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Availability of molecular markers has proven to be an efficient tool in facilitating progress in plant breeding, which is particularly important in the case of less researched crops such as cotton. Considering the obvious advantages of single nucleotide polymorphisms (SNPs) and insertion-deletion polymorphis...

journal_title：BMC genomics

authors： Li X,Gao W,Guo H,Zhang X,Fang DD,Lin Z

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:DNA microarray technology has had a great impact on muscle research and microarray gene expression data has been widely used to identify gene signatures characteristic of the studied conditions. With the rapid accumulation of muscle microarray data, it is of great interest to understand how to compare and co...

journal_title：BMC genomics

authors： Baron D,Dubois E,Bihouée A,Teusan R,Steenman M,Jourdon P,Magot A,Péréon Y,Veitia R,Savagner F,Ramstein G,Houlgatte R

更新日期：2011-02-16 00:00:00

abstract：BACKGROUND:Defensins are important components of innate immunity to combat bacterial and viral infections, and can even elicit antitumor responses. Clusters of defensin (DEF) genes are located in a 2 Mb range of the human chromosome 8p23.1. This DEF locus, however, represents one of the regions in the euchromatic part ...

journal_title：BMC genomics

authors： Taudien S,Galgoczy P,Huse K,Reichwald K,Schilhabel M,Szafranski K,Shimizu A,Asakawa S,Frankish A,Loncarevic IF,Shimizu N,Siddiqui R,Platzer M

更新日期：2004-12-10 00:00:00

abstract：BACKGROUND:Cultivated watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai var. lanatus] is an important agriculture crop world-wide. The fruit of watermelon undergoes distinct stages of development with dramatic changes in its size, color, sweetness, texture and aroma. In order to better understand the genetic and m...

journal_title：BMC genomics

authors： Guo S,Liu J,Zheng Y,Huang M,Zhang H,Gong G,He H,Ren Y,Zhong S,Fei Z,Xu Y

更新日期：2011-09-21 00:00:00

abstract：BACKGROUND:The recently developed RNA interference (RNAi) technology has created an unprecedented opportunity which allows the function of individual genes in whole organisms or cell lines to be interrogated at genome-wide scale. However, multiple issues, such as off-target effects or low efficacies in knocking down ce...

journal_title：BMC genomics

authors： Wang L,Tu Z,Sun F

更新日期：2009-05-12 00:00:00

abstract：BACKGROUND:It has been shown that nearly a quarter of the initial predicted gene models in the Plasmodium falciparum genome contain errors. Although there have been efforts to obtain complete cDNA sequences to correct the errors, the coverage of cDNA sequences on the predicted genes is still incomplete, and many gene m...

journal_title：BMC genomics

authors： López-Barragán MJ,Lemieux J,Quiñones M,Williamson KC,Molina-Cruz A,Cui K,Barillas-Mury C,Zhao K,Su XZ

更新日期：2011-11-30 00:00:00

abstract：BACKGROUND:Dense single nucleotide polymorphism (SNP) genotyping arrays provide extensive information on polymorphic variation across the genome of species of interest. Such information can be used in studies of the genetic architecture of quantitative traits and to improve the accuracy of selection in breeding program...

journal_title：BMC genomics

authors： Houston RD,Taggart JB,Cézard T,Bekaert M,Lowe NR,Downing A,Talbot R,Bishop SC,Archibald AL,Bron JE,Penman DJ,Davassi A,Brew F,Tinch AE,Gharbi K,Hamilton A

更新日期：2014-02-06 00:00:00

abstract：BACKGROUND:Mycoviruses are viruses that naturally infect and replicate in fungi. Aspergillus fumigatus, an opportunistic pathogen causing fungal lung diseases in humans and animals, was recently shown to harbour several different types of mycoviruses. A well-characterised defence against virus infection is RNA silencin...

journal_title：BMC genomics

authors： Özkan S,Mohorianu I,Xu P,Dalmay T,Coutts RHA

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:The genome of the carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii, Order: Dasyuromorphia), was sequenced in the hopes of finding a cure for or gaining a better understanding of the contagious devil facial tumor disease that is threatening the species' survival. To better understand the Tasma...

journal_title：BMC genomics

authors： Nilsson MA,Janke A,Murchison EP,Ning Z,Hallström BM

更新日期：2012-05-06 00:00:00

abstract：BACKGROUND:Soybean cyst nematode (SCN) is the most economically devastating pathogen of soybean. Two resistance loci, Rhg1 and Rhg4 primarily contribute resistance to SCN race 3 in soybean. Peking and PI 88788 are the two major sources of SCN resistance with Peking requiring both Rhg1 and Rhg4 alleles and PI 88788 only...

journal_title：BMC genomics

authors： Shi Z,Liu S,Noe J,Arelli P,Meksem K,Li Z

更新日期：2015-04-18 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa is an important opportunistic pathogen responsible for many infections in hospitalized and immunocompromised patients. Previous reports estimated that approximately 10% of its 6.6 Mbp genome varies from strain to strain and is therefore referred to as "accessory genome". Elements withi...

journal_title：BMC genomics

authors： Ozer EA,Allen JP,Hauser AR

更新日期：2014-08-29 00:00:00

abstract：BACKGROUND:Mobile genetic elements (MGEs) play an essential role in genome rearrangement and evolution, and are widely used as an important genetic tool. RESULTS:In this article, we present genetic maps of recently active Insertion Sequence (IS) elements, the simplest form of MGEs, for all sequenced cyanobacteria and ...

journal_title：BMC genomics

authors： Zhou F,Olman V,Xu Y

更新日期：2008-01-24 00:00:00

abstract：BACKGROUND:Protein phosphorylation by kinases plays crucial roles in various biological processes including signal transduction and tumorigenesis, thus a better understanding of protein phosphorylation events in cells is fundamental for studying protein functions and designing drugs to treat diseases caused by the malf...

journal_title：BMC genomics

authors： Ma H,Li G,Su Z

更新日期：2020-08-04 00:00:00