Abstract：
:This longitudinal cohort study of 324 consecutive admissions to methadone maintenance treatment between 08/1994 and 09/1997 compared 1-year outcomes of opioid-dependent patients referred from a syringe exchange program (SEP; n=81) versus other sources (n=243). All participants received stepped-based counseling. The Addiction Severity Index was completed upon admission. Treatment outcomes were assessed using weekly urine testing and days in treatment. GEE regression models were used to evaluate the association between baseline variables and treatment outcomes. SEP referrals were older, included more males and African Americans, reported greater unemployment and heavier heroin, cocaine, and injection drug use at admission. During treatment, SEP referrals used more opioids (OR 2.57; 95% CI 1.86-3.56) and cocaine (OR 2.77; 95% CI 1.93-3.95), and were less likely to complete 1 year (35%) compared to other referrals (56%; hazard ratio 1.88; 95% CI 1.35-2.62). Nevertheless, referral source was not significantly associated with outcome when adjusted for baseline characteristics. Greater baseline frequency of substance and injection drug use, and younger age were positively associated with ongoing opioid and cocaine use. African American race and baseline unemployment were also associated with ongoing cocaine use. Younger age and greater baseline cocaine use were associated with poorer retention at 1 year. The poorer treatment response of SEP referrals is likely due to higher baseline problem severity. Specialized interventions may be required to reduce drug use and improve retention in this population.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Neufeld K,King V,Peirce J,Kolodner K,Brooner R,Kidorf Mdoi
10.1016/j.drugalcdep.2008.03.026subject
Has Abstractpub_date
2008-09-01 00:00:00pages
122-9issue
1-2eissn
0376-8716issn
1879-0046pii
S0376-8716(08)00120-8journal_volume
97pub_type
杂志文章abstract：:To study the relationship between cocaine abstinence symptoms, personality, and aggression, we used the Point Subtraction Aggression Paradigm (PSAP) to measure aggression in 18 subjects admitted for the treatment of cocaine dependence. Eight subjects met criteria for antisocial personality disorder (ASPD). There was a...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(96)01335-x
更新日期：1997-03-14 00:00:00
abstract：BACKGROUND:The nucleus accumbens (NAc) is a ventral striatal structure underlying reward, reinforcement, and motivation, with extensive anatomic and functional connections to a wide range of affective processing structures (medial prefrontal cortex (mPFC), amygdala, and insula). Characterizing how acute alcohol intake ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.107811
更新日期：2020-02-01 00:00:00
abstract：:A single dose of ethanol has been shown to affect both striatal and hippocampal high-affinity choline uptake. This effect is probably mediated through effects of ethanol on acetylcholine release. Choline uptake has also been shown to be altered in ethanol-dependent animals, and these effects may be coupled to alterat...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(79)90005-x
更新日期：1979-05-01 00:00:00
abstract：BACKGROUND:The 10-item version of the cocaine craving questionnaire (CCQ-Brief) has not been validated in a mixed-gender sample, and predictive validity of the CCQ-Now and CCQ-Brief in terms of their relationship with cocaine relapse has not been demonstrated. OBJECTIVE:To further validate the CCQ-Brief in a mixed gen...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.10.002
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Gender differences in the prevalence and characteristics of misuse of methamphetamine (meth) and prescription stimulants were examined in a representative US sample of youths and young adults aged 16-25 (N=24,409). METHODS:Stimulant misusers were categorized into three mutually exclusive subgroups: meth use...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2006.12.020
更新日期：2007-07-10 00:00:00
abstract：BACKGROUND:Few studies have examined clinical trial participation rates and treatment outcomes among underserved young adults who are dependent on marijuana, the most commonly abused illicit drug. METHOD:The present study was a secondary analysis of a trial of court-referred marijuana-dependent young adults (ages 18-2...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2012.05.033
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to examine rates of traumatic events and PTSD in cocaine-dependent cases and a community comparison sample. METHODS:Participants were interviewed as part of the Family Study of Cocaine Dependence. A cross-sectional case-cohort design assessed a total of 918 participants: 459 co...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2010.05.012
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Social relationships have been demonstrated as a key predictor of relapse among addicted persons and are likely to be important determinants of HIV risk behaviors also. However, the degree to which this population can reliably and consistently identify important people (IPs) in retrospect has been understudi...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.03.038
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVES:Family studies typically use multiple sources of information on each individual including direct interviews and family history information. The aims of the present study were to: (1) assess agreement for diagnoses of specific substance use disorders between direct interviews and the family history method; (2...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.05.023
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Physical pain is considered a potential predictor of relapse in alcohol-dependent individuals after treatment. The aim of this study was to evaluate whether reductions in pain level during the follow-up period after treatment were associated with lower relapse risk. METHOD:A sample of 366 participants was re...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.11.020
更新日期：2016-01-01 00:00:00
abstract：:The N-1 alkyl side chain of the aminoalkylindole analogues (AAI) has been implicated as one of a three-point interaction with the cannabinoid CB(1) receptor. In this study, the morpholinoethyl of WIN 55,212-2 was replaced with carbon chains of varying lengths ranging from a methyl to heptyl group. Additional groups we...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(99)00152-0
更新日期：2000-08-01 00:00:00
abstract：:This article reports recent findings from a program of experimental research examining the effects of adapting judicial supervision to the risk level of drug-abusing offenders. Prior studies revealed that high-risk participants with (1) antisocial personality disorder or (2) a history of drug abuse treatment performed...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2006.10.001
更新日期：2007-05-01 00:00:00
abstract：:Familiarity with alcoholic beverages was assessed by means of a modified version of Jahoda and Cramond's 'Recognition of Smells' task (Jahoda, G. and Cramond, J. (1972) Children and Alcohol, HMSO, London). Two hundred and thirty-eight Scottish and English children aged 5.5-6.5, 7.5-8.5 and 9.5-10.5 years participated....
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(93)90043-p
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:It is particularly important to survey substance use trends in populations most impacted by the consequences of substance use. Men who have sex with men (MSM) exhibit rates of methamphetamine and other substance use that exceeds those observed among other populations in the United States. Such substance use ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.06.007
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The Community Reinforcement and Family Training (CRAFT) is a promising approach for Concerned Significant Others (CSOs) of alcohol-dependent individuals (ADI) that aims to engage treatment-refusing patients in alcohol treatment and to improve CSO functioning. To date, only two randomized controlled trials (R...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2016.04.015
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Health-related quality of life (HRQOL) is a more powerful predictor of health services use and mortality than many objective measures of health. However, in older adults the association between main alcohol drinking patterns and HRQOL is uncertain. METHODS:A prospective cohort with 2163 community-dwelling i...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.12.012
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:It is assumed that recreational use of methamphetamine can trigger acute myocardial infarction (AMI) events, but estimates of longitudinal hazards of AMI among methamphetamine users are lacking. METHODS:Retrospective cohort study: Competing-risks analysis was used to estimate time-to-AMI patterns in methamp...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.03.030
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:There is increasing concern about tampering of pharmaceutical opioids. We describe early findings from an Australian study examining the potential impact of the April 2014 introduction of an abuse-deterrent sustained-release oxycodone formulation (Reformulated OxyContin(®)). METHODS:Data on pharmaceutical o...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.02.038
更新日期：2015-06-01 00:00:00
abstract：:Fishbein and Ajzen's methodology can predict behaviour on the basis of questionnaire measures of attitudes toward the specific act and the subjective norms with respect to that behaviour which the individual experiences. In the present study this methodology was used to differentiate between the non-users, experimente...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(83)90081-9
更新日期：1983-04-01 00:00:00
abstract：:Alcohol increases libido, inhibits sexual physiological responses and adversely affects reproductive processes in men and women. The mechanisms that underlie these effects are examined and the implications of these effects are discussed. ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
doi：10.1016/0376-8716(80)90158-1
更新日期：1980-05-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to identify distinct classes of college students on the basis of recent and past drinking behaviors and evaluate how implicit and explicit measures of drinking identity predict membership in these classes. METHODS:US undergraduate students (N=456) completed online implicit (Imp...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.06.010
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:There are limited data about the extent of DSM-5 substance use disorders (SUDs) among primary care patients. METHODS:This study analyzed data from a multisite validation study of a substance use screening instrument conducted in a diverse sample of 2000 adults aged ≥18 years recruited from five primary care...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.05.048
更新日期：2017-10-01 00:00:00
abstract：:In 370 opioid-dependent patients included consecutively in a low-threshold methadone maintenance program, the effect of different variables on the retention rate was assessed. The variables included the patients' age, sex, family situation, employment status, length of heroin use, current route of drug consumption, pr...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(96)01230-6
更新日期：1996-05-01 00:00:00
abstract：PURPOSE:Previous research links cigarette use and marijuana use in adolescence with the use of other illicit substances. Limited research, however, has explored whether vaping nicotine and marijuana, along with using these substances through multiple modes of delivery (traditional cigarette/marijuana use and vaping) is...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108469
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:In this study we estimate suspected links between youthful behavioral problems and smoking of tobacco, cannabis, and coca paste. METHODS:In the Republic of Chile, school-attending youths were sampled from all 13 regions of the country, with sample size of 46,907 youths from 8th to 12th grades. A Generalized...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2009.03.010
更新日期：2009-09-01 00:00:00
abstract：:The purpose of the present investigation is to determine if various alcohol-related causes of death are associated with similar occupational groups. The California Occupational Mortality Study data set (1979-1981) provided information on primary occupation and deaths from cirrhosis, digestive cancers, injury, suicide ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(92)90098-w
更新日期：1992-02-01 00:00:00
abstract：BACKGROUND:Many studies have revealed a widespread pattern of gray matter (GM) atrophy by using voxel-based morphometry (VBM) studies involving the pathophysiology of alcohol dependence. However, the spatial localization of GM abnormalities reported in previous studies is heterogeneous. Here, we aimed to investigate th...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,meta分析
doi：10.1016/j.drugalcdep.2015.05.030
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Recreational drug use has increased in recent years, especially among MSM, and has been found to be associated with higher risk of HIV infection. However, there is limited information about current recreational drug use among MSM in Shenzhen which is an international gateway city to China with a rapidly expa...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.09.004
更新日期：2017-12-01 00:00:00
abstract：:This paper examines patterns of self-reported alcohol, tobacco and illicit drug use amongst a representative sample of 600 qualified nurses in the Lothian Region of Scotland. General levels of alcohol use were not exceptional. Even so, levels of tobacco smoking and the use of illicit drugs were higher than for the gen...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(91)90076-b
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND:Methadone maintenance therapy (MMT) is an efficacious form of medication assisted treatment for opioid use disorder (OUD), yet many individuals on MMT relapse. Chronic pain and deficits in positive affective response to natural rewards may result in dysphoria that fuels opioid craving and promotes relapse. A...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2019.07.007
更新日期：2019-10-01 00:00:00
