Abstract：
:We describe a 37-yr-old man who developed central pontine myelinolysis (CPM) after allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia. After HSCT, desquamation developed on the whole body accompanied by hyperbilirubinemia. The liver biopsy of the patient indicated graft-versus-host disease- related liver disease, and the dose of methylprednisolone was increased. Then, the patient developed altered mentality with eye ball deviation to the left, for which electroencephalogram and magnetic resonance imaging (MRI) scans were done. Brain MRI scan demonstrated the imaging findings consistent with central pontine myelinolysis and extrapontine myelinolysis. He did not have any hyponatremia episode during hospitalization prior to the MRI scan. To the best of our knowledge, presentation of CPM after allogeneic HSCT is extremely rare in cases where patients have not exhibited any episodes of significant hyponatremia. We report a rare case in which hepatic dysfunction due to graft-versus-host disease has a strong association with CPM after HSCT.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Lim KH,Kim S,Lee YS,Kim KH,Kim J,Rhee Jy,Kim HJ,Yi HG,Oh SY,Lim JH,Han SW,Lee S,Kim I,Yoon SS,Park S,Kim BKdoi
10.3346/jkms.2008.23.2.324subject
Has Abstractpub_date
2008-04-01 00:00:00pages
324-7issue
2eissn
1011-8934issn
1598-6357pii
200804324journal_volume
23pub_type
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