Overlapping genes in the human and mouse genomes.

Abstract:

BACKGROUND:Increasing evidence suggests that overlapping genes are much more common in eukaryotic genomes than previously thought. In this study we identified and characterized the overlapping genes in a set of 13,484 pairs of human-mouse orthologous genes. RESULTS:About 10% of the genes under study are overlapping genes, the majority of which are different-strand overlaps. The majority of the same-strand overlaps are embedded forms, whereas most different-strand overlaps are not embedded and in the convergent transcription orientation. Most of the same-strand overlapping gene pairs show at least a tenfold difference in length, much larger than the length difference between non-overlapping neighboring gene pairs. The length difference between the two different-strand overlapping genes is less dramatic. Over 27% of the different-strand-overlap relationships are shared between human and mouse, compared to only approximately 8% conservation for same-strand-overlap relationships. More than 96% of the same-strand and different-strand overlaps that are not shared between human and mouse have both genes located on the same chromosomes in the species that does not show the overlap. We examined the causes of transition between the overlapping and non-overlapping states in the two species and found that 3' UTR change plays an important role in the transition. CONCLUSION:Our study contributes to the understanding of the evolutionary transition between overlapping genes and non-overlapping genes and demonstrates the high rates of evolutionary changes in the un-translated regions.

journal_name

BMC Genomics

journal_title

BMC genomics

authors

Sanna CR,Li WH,Zhang L

doi

10.1186/1471-2164-9-169

subject

Has Abstract

pub_date

2008-04-14 00:00:00

pages

169

issn

1471-2164

pii

1471-2164-9-169

journal_volume

9

pub_type

杂志文章
  • The gonadal transcriptome of the unisexual Amazon molly Poecilia formosa in comparison to its sexual ancestors, Poecilia mexicana and Poecilia latipinna.

    abstract:BACKGROUND:The unisexual Amazon molly (Poecilia formosa) originated from a hybridization between two sexual species, the sailfin molly (Poecilia latipinna) and the Atlantic molly (Poecilia mexicana). The Amazon molly reproduces clonally via sperm-dependent parthenogenesis (gynogenesis), in which the sperm of closely re...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-017-4382-2

    authors: Schedina IM,Groth D,Schlupp I,Tiedemann R

    更新日期:2018-01-03 00:00:00

  • Histone H3 lysine 4 methyltransferase is required for facultative heterochromatin at specific loci.

    abstract:BACKGROUND:Histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 lysine 9 tri-methylation (H3K9me3) are widely perceived to be opposing and often mutually exclusive chromatin modifications. However, both are needed for certain light-activated genes in Neurospora crassa (Neurospora), including frequency (frq) and...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-019-5729-7

    authors: Zhu Q,Ramakrishnan M,Park J,Belden WJ

    更新日期:2019-05-08 00:00:00

  • De novo transcriptome analysis of Perna viridis highlights tissue-specific patterns for environmental studies.

    abstract:BACKGROUND:The tropical green-lipped mussel Perna viridis is a common biomonitor throughout the Indo-Pacific region that is used for environmental monitoring and ecotoxicological investigations. However, there is limited molecular data available regarding this species. We sought to establish a global transcriptome data...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-15-804

    authors: Leung PT,Ip JC,Mak SS,Qiu JW,Lam PK,Wong CK,Chan LL,Leung KM

    更新日期:2014-09-19 00:00:00

  • Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response.

    abstract:BACKGROUND:Designing sustainable animal production systems that better balance productivity and resistance to disease is a major concern. In order to address questions related to immunity and resistance to disease in pig, it is necessary to increase knowledge on its immune system and to produce efficient tools dedicate...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-11-292

    authors: Gao Y,Flori L,Lecardonnel J,Esquerré D,Hu ZL,Teillaud A,Lemonnier G,Lefèvre F,Oswald IP,Rogel-Gaillard C

    更新日期:2010-05-11 00:00:00

  • Concurrent host-pathogen gene expression in the lungs of pigs challenged with Actinobacillus pleuropneumoniae.

    abstract:BACKGROUND:Actinobacillus pleuropneumoniae causes pleuropneumonia in pigs, a disease which is associated with high morbidity and mortality, as well as impaired animal welfare. To obtain in-depth understanding of this infection, the interplay between virulence factors of the pathogen and defense mechanisms of the porcin...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1557-6

    authors: Brogaard L,Klitgaard K,Heegaard PM,Hansen MS,Jensen TK,Skovgaard K

    更新日期:2015-05-28 00:00:00

  • Simple sequence repeats and compositional bias in the bipartite Ralstonia solanacearum GMI1000 genome.

    abstract:BACKGROUND:Ralstonia solanacearum is an important plant pathogen. The genome of R. solananearum GMI1000 is organised into two replicons (a 3.7-Mb chromosome and a 2.1-Mb megaplasmid) and this bipartite genome structure is characteristic for most R. solanacearum strains. To determine whether the megaplasmid was acquired...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-4-10

    authors: Coenye T,Vandamme P

    更新日期:2003-03-17 00:00:00

  • Mining statistically-solid k-mers for accurate NGS error correction.

    abstract:BACKGROUND:NGS data contains many machine-induced errors. The most advanced methods for the error correction heavily depend on the selection of solid k-mers. A solid k-mer is a k-mer frequently occurring in NGS reads. The other k-mers are called weak k-mers. A solid k-mer does not likely contain errors, while a weak k-...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-018-5272-y

    authors: Zhao L,Xie J,Bai L,Chen W,Wang M,Zhang Z,Wang Y,Zhao Z,Li J

    更新日期:2018-12-31 00:00:00

  • Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability.

    abstract:BACKGROUND:LEF1/TCF transcription factors and their activator β-catenin are effectors of the canonical Wnt pathway. Although Wnt/β-catenin signaling has been implicated in neurodegenerative and psychiatric disorders, its possible role in the adult brain remains enigmatic. To address this issue, we sought to identify th...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-13-635

    authors: Wisniewska MB,Nagalski A,Dabrowski M,Misztal K,Kuznicki J

    更新日期:2012-11-17 00:00:00

  • Single Cell Explorer, collaboration-driven tools to leverage large-scale single cell RNA-seq data.

    abstract:BACKGROUND:Single cell transcriptome sequencing has become an increasingly valuable technology for dissecting complex biology at a resolution impossible with bulk sequencing. However, the gap between the technical expertise required to effectively work with the resultant high dimensional data and the biological experti...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-019-6053-y

    authors: Feng D,Whitehurst CE,Shan D,Hill JD,Yue YG

    更新日期:2019-08-27 00:00:00

  • Effects of elevated seawater pCO(2) on gene expression patterns in the gills of the green crab, Carcinus maenas.

    abstract:BACKGROUND:The green crab Carcinus maenas is known for its high acclimation potential to varying environmental abiotic conditions. A high ability for ion and acid-base regulation is mainly based on an efficient regulation apparatus located in gill epithelia. However, at present it is neither known which ion transport p...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-12-488

    authors: Fehsenfeld S,Kiko R,Appelhans Y,Towle DW,Zimmer M,Melzner F

    更新日期:2011-10-06 00:00:00

  • ESAP plus: a web-based server for EST-SSR marker development.

    abstract:BACKGROUND:Simple sequence repeats (SSRs) have become widely used as molecular markers in plant genetic studies due to their abundance, high allelic variation at each locus and simplicity to analyze using conventional PCR amplification. To study plants with unknown genome sequence, SSR markers from Expressed Sequence T...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-016-3328-4

    authors: Ponyared P,Ponsawat J,Tongsima S,Seresangtakul P,Akkasaeng C,Tantisuwichwong N

    更新日期:2016-12-22 00:00:00

  • Comparative transcriptome analysis of the interaction between Actinidia chinensis var. chinensis and Pseudomonas syringae pv. actinidiae in absence and presence of acibenzolar-S-methyl.

    abstract:BACKGROUND:Since 2007, bacterial canker caused by Pseudomonas syringae pv. actinidiae (Psa) has become a pandemic disease leading to important economic losses in every country where kiwifruit is widely cultivated. Options for controlling this disease are very limited and rely primarily on the use of bactericidal compou...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-018-4967-4

    authors: Michelotti V,Lamontanara A,Buriani G,Orrù L,Cellini A,Donati I,Vanneste JL,Cattivelli L,Tacconi G,Spinelli F

    更新日期:2018-08-06 00:00:00

  • Plasmid composition in Aeromonas salmonicida subsp. salmonicida 01-B526 unravels unsuspected type three secretion system loss patterns.

    abstract:BACKGROUND:Aeromonas salmonicida subsp. salmonicida is a ubiquitous psychrophilic waterborne bacterium and a fish pathogen. The numerous mobile elements, especially insertion sequences (IS), in its genome promote rearrangements that impact its phenotype. One of the main virulence factors of this bacterium, its type thr...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-017-3921-1

    authors: Tanaka KH,Vincent AT,Emond-Rheault JG,Adamczuk M,Frenette M,Charette SJ

    更新日期:2017-07-12 00:00:00

  • Classification and phylogenetic analyses of the Arabidopsis and tomato G-type lectin receptor kinases.

    abstract:BACKGROUND:Pathogen perception by plants is mediated by plasma membrane-localized immune receptors that have varied extracellular domains. Lectin receptor kinases (LecRKs) are among these receptors and are subdivided into 3 classes, C-type LecRKs (C-LecRKs), L-type LecRKs (L-LecRKs) and G-type LecRKs (G-LecRKs). While ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-018-4606-0

    authors: Teixeira MA,Rajewski A,He J,Castaneda OG,Litt A,Kaloshian I

    更新日期:2018-04-06 00:00:00

  • Whole genome comparative analysis of transposable elements provides new insight into mechanisms of their inactivation in fungal genomes.

    abstract:BACKGROUND:Transposable Elements (TEs) are key components that shape the organization and evolution of genomes. Fungi have developed defense mechanisms against TE invasion such as RIP (Repeat-Induced Point mutation), MIP (Methylation Induced Premeiotically) and Quelling (RNA interference). RIP inactivates repeated sequ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1347-1

    authors: Amselem J,Lebrun MH,Quesneville H

    更新日期:2015-02-28 00:00:00

  • Comparative genomic analysis revealed great plasticity and environmental adaptation of the genomes of Enterococcus faecium.

    abstract:BACKGROUND:As an important nosocomial pathogen, Enterococcus faecium has received increasing attention in recent years. However, a large number of studies have focused on the hospital-associated isolates and ignored isolates originated from the natural environments. RESULTS:In this study, comparative genomic analysis ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-019-5975-8

    authors: Zhong Z,Kwok LY,Hou Q,Sun Y,Li W,Zhang H,Sun Z

    更新日期:2019-07-22 00:00:00

  • Correction to: Proteotranscriptomics assisted gene annotation and spatial proteomics of Bombyx mori BmN4 cell line.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:BMC genomics

    pub_type: 已发布勘误

    doi:10.1186/s12864-020-07211-8

    authors: Levin M,Scheibe M,Butter F

    更新日期:2020-11-12 00:00:00

  • Genomics of sex allocation in the parasitoid wasp Nasonia vitripennis.

    abstract:BACKGROUND:Whilst adaptive facultative sex allocation has been widely studied at the phenotypic level across a broad range of organisms, we still know remarkably little about its genetic architecture. Here, we explore the genome-wide basis of sex ratio variation in the parasitoid wasp Nasonia vitripennis, perhaps the b...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-020-06904-4

    authors: Pannebakker BA,Cook N,van den Heuvel J,van de Zande L,Shuker DM

    更新日期:2020-07-20 00:00:00

  • Identification of functional regulatory elements in the human genome using pooled CRISPR screens.

    abstract:BACKGROUND:Genome-scale pooled CRISPR screens are powerful tools for identifying genetic dependencies across varied cellular processes. The vast majority of CRISPR screens reported to date have focused exclusively on the perturbation of protein-coding gene function. However, protein-coding genes comprise < 2% of the se...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-020-6497-0

    authors: Borys SM,Younger ST

    更新日期:2020-01-31 00:00:00

  • Identifying Mendelian disease genes with the variant effect scoring tool.

    abstract:BACKGROUND:Whole exome sequencing studies identify hundreds to thousands of rare protein coding variants of ambiguous significance for human health. Computational tools are needed to accelerate the identification of specific variants and genes that contribute to human disease. RESULTS:We have developed the Variant Eff...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-14-S3-S3

    authors: Carter H,Douville C,Stenson PD,Cooper DN,Karchin R

    更新日期:2013-01-01 00:00:00

  • Comparison of leaf transcriptome in response to Rhizoctonia solani infection between resistant and susceptible rice cultivars.

    abstract:BACKGROUND:Sheath blight (SB), caused by Rhizoctonia solani, is a common rice disease worldwide. Currently, rice cultivars with robust resistance to R. solani are still lacking. To provide theoretic basis for molecular breeding of R. solani-resistant rice cultivars, the changes of transcriptome profiles in response to ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-020-6645-6

    authors: Shi W,Zhao SL,Liu K,Sun YB,Ni ZB,Zhang GY,Tang HS,Zhu JW,Wan BJ,Sun HQ,Dai JY,Sun MF,Yan GH,Wang AM,Zhu GY

    更新日期:2020-03-19 00:00:00

  • Unlocking the bovine genome.

    abstract::The draft genome sequence of cattle (Bos taurus) has now been analyzed by the Bovine Genome Sequencing and Analysis Consortium and the Bovine HapMap Consortium, which together represent an extensive collaboration involving more than 300 scientists from 25 different countries. ...

    journal_title:BMC genomics

    pub_type: 社论

    doi:10.1186/1471-2164-10-193

    authors: Tellam RL,Lemay DG,Van Tassell CP,Lewin HA,Worley KC,Elsik CG

    更新日期:2009-04-24 00:00:00

  • Expression profile of genes regulated by activity of the Na-H exchanger NHE1.

    abstract:BACKGROUND:In mammalian cells changes in intracellular pH (pHi), which are predominantly controlled by activity of plasma membrane ion exchangers, regulate a diverse range of normal and pathological cellular processes. How changes in pHi affect distinct cellular processes has primarily been determined by evaluating pro...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-5-46

    authors: Putney LK,Barber DL

    更新日期:2004-07-16 00:00:00

  • MetaTopics: an integration tool to analyze microbial community profile by topic model.

    abstract:BACKGROUND:Deciphering taxonomical structures based on high dimensional sequencing data is still challenging in metagenomics study. Moreover, the common workflow processed in this field fails to identify microbial communities and their effect on a specific disease status. Even the relationships and interactions between...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-016-3257-2

    authors: Yan J,Chuai G,Qi T,Shao F,Zhou C,Zhu C,Yang J,Yu Y,Shi C,Kang N,He Y,Liu Q

    更新日期:2017-01-25 00:00:00

  • Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication.

    abstract:BACKGROUND:Advances in genome technology have simplified a new comprehension of the genetic and historical processes crucial to rapid phenotypic evolution under domestication. To get new insight into the genetic basis of the dog domestication process, we conducted whole-genome sequence analysis of three wolves and thre...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-020-6619-8

    authors: Amiri Ghanatsaman Z,Wang GD,Asadollahpour Nanaei H,Asadi Fozi M,Peng MS,Esmailizadeh A,Zhang YP

    更新日期:2020-03-04 00:00:00

  • The unique genomic landscape surrounding the EPSPS gene in glyphosate resistant Amaranthus palmeri: a repetitive path to resistance.

    abstract:BACKGROUND:The expanding number and global distributions of herbicide resistant weedy species threaten food, fuel, fiber and bioproduct sustainability and agroecosystem longevity. Amongst the most competitive weeds, Amaranthus palmeri S. Wats has rapidly evolved resistance to glyphosate primarily through massive amplif...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-016-3336-4

    authors: Molin WT,Wright AA,Lawton-Rauh A,Saski CA

    更新日期:2017-01-17 00:00:00

  • Generation and analysis of large-scale expressed sequence tags (ESTs) from a full-length enriched cDNA library of porcine backfat tissue.

    abstract:BACKGROUND:Genome research in farm animals will expand our basic knowledge of the genetic control of complex traits, and the results will be applied in the livestock industry to improve meat quality and productivity, as well as to reduce the incidence of disease. A combination of quantitative trait locus mapping and mi...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-7-36

    authors: Kim TH,Kim NS,Lim D,Lee KT,Oh JH,Park HS,Jang GW,Kim HY,Jeon M,Choi BH,Lee HY,Chung HY,Kim H

    更新日期:2006-02-27 00:00:00

  • De novo assembly of middle-sized genome using MinION and Illumina sequencers.

    abstract:BACKGROUND:The plastid acquisition by secondary endosymbiosis is a driving force for the algal evolution, and the comparative genomics was required to examine the genomic change of symbiont. Therefore, we established a pipeline of a de novo assembly of middle-sized genomes at a low cost and with high quality using long...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-018-5067-1

    authors: Minei R,Hoshina R,Ogura A

    更新日期:2018-09-24 00:00:00

  • Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies.

    abstract:BACKGROUND:By assaying hundreds of thousands of single nucleotide polymorphisms, genome wide association studies (GWAS) allow for a powerful, unbiased review of the entire genome to localize common genetic variants that influence health and disease. Although it is widely recognized that some correction for multiple tes...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-9-516

    authors: Duggal P,Gillanders EM,Holmes TN,Bailey-Wilson JE

    更新日期:2008-10-31 00:00:00

  • Tracking the adoption of bread wheat varieties in Afghanistan using DNA fingerprinting.

    abstract:BACKGROUND:Wheat is the most important staple crop in Afghanistan and accounts for the main part of cereal production. However, wheat production has been unstable during the last decades and the country depends on seed imports. Wheat research in Afghanistan has emphasized releases of new, high-yielding and disease resi...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-019-6015-4

    authors: Dreisigacker S,Sharma RK,Huttner E,Karimov A,Obaidi MQ,Singh PK,Sansaloni C,Shrestha R,Sonder K,Braun HJ

    更新日期:2019-08-19 00:00:00