Formulation of Fe3O4/acrylate co-polymer nanocomposites as potential drug carriers.

abstract：:This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate rhodamine-123 in comparison to the trans- and paracellular marker FD 4 both in rat i...

journal_title：Drug delivery

authors： Schmitz T,Hombach J,Bernkop-Schnürch A

更新日期：2008-05-01 00:00:00

abstract：:Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week ...

journal_title：Drug delivery

authors： Terraneo L,Bianciardi P,Virgili E,Finati E,Samaja M,Paroni R

更新日期：2017-11-01 00:00:00

abstract：:At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...

journal_title：Drug delivery

authors： Chang M,Wu M,Li H

更新日期：2018-11-01 00:00:00

abstract：:A conjugate consisting of streptavidin (biotinylated transferrin)-biotinylated polylysine for DNA delivery to cells was modified by partial nicotinylation of the polylysine component of the conjugate and used for transfection studies. A conjugate of biotin10-nicotinyl60-polylysine250 containing 60 weakly basic nicotin...

journal_title：Drug delivery

authors： Quick G,van Zyl J,Hawtrey A,Ariatti M

更新日期：2000-10-01 00:00:00

abstract：:The objective of this study was to establish a drug transport study using human nasal epithelial (HNE) cell monolayers cultured by the air-liquid interface (ALI) method using serum-free medium (BEGM:DME/F12, 50:50). The cells were developed and characterized in comparison to those that have been previously cultured by...

journal_title：Drug delivery

authors： Lee MK,Yoo JW,Lin H,Kim YS,Kim DD,Choi YM,Park SK,Lee CH,Roh HJ

更新日期：2005-09-01 00:00:00

abstract：CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

journal_title：Drug delivery

authors： Balata G,El Nahas HM,Radwan S

更新日期：2014-02-01 00:00:00

abstract：:Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AGM. The optimized in...

journal_title：Drug delivery

authors： Fatouh AM,Elshafeey AH,Abdelbary A

更新日期：2017-11-01 00:00:00

abstract：:Electro-phonophoresis (EP) has been used in various clinical fields. The objective of present study is to evaluate the skin permeability of isoniazid (INH) and rifampicin (RIF) in patients with tuberculous lymphadenitis with the aid of EP to validate the clinical applications of this transdermal delivery system for th...

journal_title：Drug delivery

authors： Chen S,Qin M,Han Y,Zhao L,Fu Y,Shang Y,Liu Z,Huang H

更新日期：2016-06-01 00:00:00

abstract：:Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...

journal_title：Drug delivery

authors： Gupta H,Jain S,Mathur R,Mishra P,Mishra AK,Velpandian T

更新日期：2007-11-01 00:00:00

abstract：:In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...

journal_title：Drug delivery

authors： Liu C,Shan W,Liu M,Zhu X,Xu J,Xu Y,Huang Y

更新日期：2016-07-01 00:00:00

abstract：:The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...

journal_title：Drug delivery

authors： Zhang Y,Liu Y,Luo Y,Yao Q,Zhong Y,Tian B,Tang X

更新日期：2016-07-01 00:00:00

abstract：:Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body's first-pass metabolism which reduces t...

journal_title：Drug delivery

authors： Poh W,Ab Rahman N,Ostrovski Y,Sznitman J,Pethe K,Loo SCJ

更新日期：2019-12-01 00:00:00

abstract：:For the treatment of ocular keratitis acyclovir, as a highly specific inhibitor of herpes virus replication, is applied topically into the eye. The objective of this study was to design and evaluate freeze-dried, bioadhesive and biodegredable acyclovir ocular minitablets for prolonged local drug action. The sponge-lik...

journal_title：Drug delivery

authors： Refai H,Tag R

更新日期：2011-01-01 00:00:00

abstract：:The main purpose of this work was to develop and evaluate a self-emulsifying drug delivery system (SEDDS) of piperine to enhance its solubility and bioavailability. The formulation was optimized by solubility test and ternary phase diagrams. Then physiochemical properties and in vitro release of SEDDS were characteriz...

journal_title：Drug delivery

authors： Shao B,Cui C,Ji H,Tang J,Wang Z,Liu H,Qin M,Li X,Wu L

更新日期：2015-01-01 00:00:00

abstract：:Small interfering RNA (siRNA) exhibits great potential as a novel therapeutic option due to its highly sequence-specific ability to silence genes. However, efficient and safe delivery carriers are required for developing novel therapeutic paradigms. Thus, the successful development of efficient delivery platforms for ...

journal_title：Drug delivery

authors： Xia Y,Tang G,Wang C,Zhong J,Chen Y,Hua L,Li Y,Liu H,Zhu B

更新日期：2020-12-01 00:00:00

abstract：:The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. T...

journal_title：Drug delivery

authors： Barakat NS,Elbagory IM,Almurshedi AS

更新日期：2009-01-01 00:00:00

abstract：CONTEXT:Bisphosphonates (BPs) are widely used for prevention and treatment of osteoporosis. BPs are known as gold standard for osteoporosis (OP) treatment due to their positive results in clinical studies. But some serious side effects are associated with BPs like gastrointestinal adverse effect i.e. esophagitis and ul...

journal_title：Drug delivery

authors： Fazil M,Baboota S,Sahni JK,Ameeduzzafar,Ali J

更新日期：2015-01-01 00:00:00

abstract：:Hot-melt extrusion (HME) plays an important role in preparing implants as local drug delivery systems in pharmaceutical fields. Here, a new PLA/PEG-PPG-PEG/Dexamethasone (PLA/F68/Dex) implant prepared by HME has been developed. Importantly, the implant was successfully achieved to control release of immunosuppressive ...

journal_title：Drug delivery

authors： Li D,Guo G,Deng X,Fan R,Guo Q,Fan M,Liang J,Luo F,Qian Z

更新日期：2013-04-01 00:00:00

abstract：:Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was...

journal_title：Drug delivery

authors： Maher EM,Ali AM,Salem HF,Abdelrahman AA

更新日期：2016-10-01 00:00:00

abstract：:A novel niosomal delivery system was designed and investigated for the targeted delivery of daunorubicin (DNR) against acute myeloid leukemia (AML). Anti-CD123 antibodies conjugated to Mal-PEG2000-DSPE were incorporated into normal niosomes (NS) via a post insertion method to afford antibody-modified niosomes (CD123-N...

journal_title：Drug delivery

authors： Liu FR,Jin H,Wang Y,Chen C,Li M,Mao SJ,Wang Q,Li H

更新日期：2017-11-01 00:00:00

abstract：:Traditional in situ gel forming systems are potential applications for parenteral administration but always accompanied with burst release. To overcome this limitation, the tinidazole (TNZ)-loaded in situ gel forming system using a diblock copolymer, monomethoxy poly(ethylene glycol)-block-poly(d,l-lactide) (mPEG-PDLL...

journal_title：Drug delivery

authors： Tian Y,Shen Y,Jv M

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor thera...

journal_title：Drug delivery

authors： Thingale AD,Shaikh KS,Channekar PR,Galgatte UC,Chaudhari PD,Bothiraja C

更新日期：2015-01-01 00:00:00

abstract：:The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...

journal_title：Drug delivery

authors： Staroverov SA,Pristensky DV,Yermilov DN,Gabalov KP,Zhemerichkin DA,Sidorkin VA,Shcherbakov AA,Shchyogolev SY,Dykman LA

更新日期：2006-09-01 00:00:00

abstract：:To develop statistically optimized brain targeted Tween 80 coated chitosan nanoparticulate formulation for oral delivery of doxycycline hydrochloride for the treatment of psychosis and to evaluate its protective effect on ketamine induced behavioral, biochemical, neurochemical and histological alterations in mice. 32 ...

journal_title：Drug delivery

authors： Yadav M,Parle M,Sharma N,Dhingra S,Raina N,Jindal DK

更新日期：2017-11-01 00:00:00

abstract：:The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196 showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monoc...

journal_title：Drug delivery

authors： Choi JS,Cho YA,Chun IK,Jung SY,Gwak HS

更新日期：2007-02-01 00:00:00

abstract：:In vitro characteristics of the human erythrocytes loaded by enalaprilat have been evaluated. Erythrocytes obtained from a healthy volunteer were loaded by enalaprilat using the hypotonic preswelling method, and the loading parameters, drug-release kinetics, hematological indices, particle size distribution, scanning ...

journal_title：Drug delivery

authors： Hamidi M,Tajerzadeh H,Dehpour AR,Rouini MR,Ejtemaee-Mehr S

更新日期：2001-10-01 00:00:00

abstract：CONTEXT:Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction, decreased uptake by tumor tissue, and increased exposu...

journal_title：Drug delivery

authors： Jiang S,Gong X,Zhao X,Zu Y

更新日期：2015-02-01 00:00:00

abstract：:Bone-metastasis prostate cancer (BMPCa)-targeting gene therapy is gaining increasing concern in recent years. The peptide T7-modified polypeptide nanoparticles for delivery DNA (CRD-PEG-T7/pPMEPA1) was prepared as our previous study. However, the feasibility of CRD-PEG-T7/pPMEPA1 for BMPCa treatment, the mechanisms un...

journal_title：Drug delivery

authors： Gu Y,Chen X,Zhang H,Wang H,Chen H,Huang S,Xu Y,Zhang Y,Wu X,Chen J

更新日期：2020-12-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis is a chronic autoimmune disease affecting nearly five million people worldwide. Among all drug delivery system, oral administration is the most preferable route for colon-specific targeting and the treatment of IBD. Herein, an amphiphilic ...

journal_title：Drug delivery

authors： Qiao H,Fang D,Chen J,Sun Y,Kang C,Di L,Li J,Chen Z,Chen J,Gao Y

更新日期：2017-11-01 00:00:00

abstract：:The distinct hormone molecules and receptors, such as follicle-stimulating hormone receptor (FSHR) in ovarian cancer, provide opportunities for more precisely targeted therapy. We previously developed FSHR-mediated nanoparticles and found that FSH peptides on the surface of nanoparticles improved the delivery of short...

journal_title：Drug delivery

authors： Hong SS,Zhang MX,Zhang M,Yu Y,Chen J,Zhang XY,Xu CJ

更新日期：2018-11-01 00:00:00