Survival and health in liveborn infants with transposition of great arteries--a population-based study.

Abstract:

OBJECTIVE:To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA). DESIGN:Population-based data from 7 European registries of congenital malformations (EUROCAT). RESULTS:Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10,000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development. CONCLUSIONS:In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.

journal_name

Congenit Heart Dis

journal_title

Congenital heart disease

authors

Garne E,Loane MA,Nelen V,Bakker MK,Gener B,Abramsky L,Addor MC,Queisser-Luft A

doi

10.1111/j.1747-0803.2007.00093.x

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

165-9

issue

3

eissn

1747-079X

issn

1747-0803

pii

CHD093

journal_volume

2

pub_type

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