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Nephrogenic systemic fibrosis--implications for nephrologists.

Abstract：

:Nephrogenic systemic fibrosis (NSF) is a debilitating disorder seen in-patient with advanced chronic kidney disease (CKD). Recent evidence suggests a link between NSF and the administration of gadolinium-based contrast agents (Gd-CA). In addition, other risk factors have also been suggested to facilitate the development of NSF in this population after Gd-CA. These include metabolic acidosis, high-dose erythropoietin therapy, and the altered mineral metabolism of CKD. While it is possible that these factors may increase the risk of NSF after Gd-CA exposure, they may also simply reflect conditions that increase the risk of getting exposed to Gd-CA, particularly at high doses. Furthermore, given the risk of NSF in CKD, physicians must weigh the risks of NSF versus the risk of contrast-induced nephropathy (CIN) with iodinated agents in this population. In this review, we will provide a nephrologist's perspective on these issues and the nephrologist's role in the prevention of NSF.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Saab G,Abu-Alfa A

doi

10.1016/j.ejrad.2008.01.028

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

208-12

issue

2

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(08)00048-X

journal_volume

66

pub_type

杂志文章,评审

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