Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling.

abstract：:Clathrin-mediated endocytosis requires cargo-specific adaptor proteins that recognize specific receptors and recruit them into coated pits. ARH [also called low-density lipoprotein receptor (LDLR) adaptor protein] serves as an adaptor for LDLR endocytosis in liver. However, ARH is dispensable for LDL uptake by some ot...

journal_title：Journal of cell science

authors： Maurer ME,Cooper JA

更新日期：2006-10-15 00:00:00

abstract：:Several properties of cadherin-4 and cadherin-5 were characterized by using the cDNA transfection approach. The proteins of both cadherins had a relative molecular mass of about 130 kDa and were present at the cell periphery, especially at cell-cell contact sites. These cadherins were easily digested with trypsin, and...

journal_title：Journal of cell science

authors： Tanihara H,Kido M,Obata S,Heimark RL,Davidson M,St John T,Suzuki S

更新日期：1994-06-01 00:00:00

abstract：:A high molecular weight tight junction-associated protein, ZO-1, has been demonstrated in liver (hepatocytes) and in both epithelium and endothelium. We carried out studies to examine the presence of the protein in vascular endothelial cell cultures and several other types of cultured cells, and the relationship betwe...

journal_title：Journal of cell science

authors： Li CX,Poznansky MJ

更新日期：1990-10-01 00:00:00

abstract：:Laminins are heterotrimeric glycoproteins of the extracellular matrix that are secreted by epithelial cells and which are crucial for the normal structure and function of the basement membrane. We have generated a mouse harboring a conditional knockout of α3 laminin (Lama3(fl/fl)), one of the main laminin subunits in ...

journal_title：Journal of cell science

authors： Urich D,Eisenberg JL,Hamill KJ,Takawira D,Chiarella SE,Soberanes S,Gonzalez A,Koentgen F,Manghi T,Hopkinson SB,Misharin AV,Perlman H,Mutlu GM,Budinger GR,Jones JC

更新日期：2011-09-01 00:00:00

abstract：:Nuclear actin plays an important role in many processes that regulate gene expression. Cytoplasmic actin dynamics are tightly controlled by numerous actin-binding proteins, but regulation of nuclear actin has remained unclear. Here, we performed a genome-wide RNA interference (RNAi) screen in Drosophila cells to ident...

journal_title：Journal of cell science

authors： Dopie J,Rajakylä EK,Joensuu MS,Huet G,Ferrantelli E,Xie T,Jäälinoja H,Jokitalo E,Vartiainen MK

更新日期：2015-07-01 00:00:00

abstract：:The HB2 cell line, developed from luminal epithelial cells cultured from milk, forms ball-like structures in collagen gels which show a uniform branching response to hepatocyte growth factor. The alpha2beta1 integrin is the major integrin expressed by luminal epithelial cells, and the role of this integrin in mammary ...

journal_title：Journal of cell science

authors： Alford D,Baeckström D,Geyp M,Pitha P,Taylor-Papadimitriou J

更新日期：1998-02-01 00:00:00

abstract：:In sciarid flies (Diptera, Sciaridae), one or two paternally derived X chromosomes are discarded from the soma at early cleavages to determine the sex of the embryo (XX, females; X0, males). X chromosome(s) elimination is achieved by an abnormal anaphase segregation so that X sister chromatids do not reach the poles a...

journal_title：Journal of cell science

authors： Escribá MC,Goday C

更新日期：2013-07-15 00:00:00

abstract：:Transcription factor E2F plays an important role in coordinating and integrating early cell cycle progression with the transcription apparatus. It is known that physiological E2F arises when a member of two families of proteins, E2F and DP, interact as E2F/DP heterodimers and that transcriptional activity is regulated...

journal_title：Journal of cell science

authors： Allen KE,de la Luna S,Kerkhoven RM,Bernards R,La Thangue NB

更新日期：1997-11-01 00:00:00

abstract：:A key signaling event that is responsible for gradient sensing in eukaryotic cell chemotaxis is a phosphatidylinositol (PtdIns) lipid reaction system. The self-organization activity of this PtdIns lipid system induces an inherent polarity, even in the absence of an external chemoattractant gradient, by producing a loc...

journal_title：Journal of cell science

authors： Shibata T,Nishikawa M,Matsuoka S,Ueda M

更新日期：2012-11-01 00:00:00

abstract：:The Down syndrome critical region (DSCR) on Chromosome 21 contains many genes whose duplication may lead to the major phenotypic features of Down syndrome and especially the associated mental retardation. However, the functions of DSCR genes are mostly unknown and their possible involvement in key brain developmental ...

journal_title：Journal of cell science

authors： Berto G,Camera P,Fusco C,Imarisio S,Ambrogio C,Chiarle R,Silengo L,Di Cunto F

更新日期：2007-06-01 00:00:00

abstract：:8-Hydroxyquinoline (HQ) chelates Mg2+ and Mn2+ and, secondarily, affects the activities of DNA and RNA polymerases. The in vivo effect of HQ has been estimated in Allium cepa L. meristems growing under new growth kinetics in the presence of this agent. HQ (at both 5 X 10(-5) M and 10(-4) M) depressed incorporation of ...

journal_title：Journal of cell science

authors： Ferrero ML,De la Torre C

更新日期：1986-02-01 00:00:00

abstract：:Cancer cells thrive when challenged with proteotoxic stress by inducing components of the protein folding, proteasome, autophagy and unfolded protein response (UPR) pathways. Consequently, specific molecular chaperones have been validated as targets for anti-cancer therapies. For example, inhibition of Hsp70 family pr...

journal_title：Journal of cell science

authors： Sannino S,Guerriero CJ,Sabnis AJ,Stolz DB,Wallace CT,Wipf P,Watkins SC,Bivona TG,Brodsky JL

更新日期：2018-09-05 00:00:00

abstract：:Clusterin expression is increased in tissues undergoing apoptosis, including neurodegenerative retina, but the causal relationships remain to be clarified. To test the hypothesis that overexpression of clusterin could induce apoptosis in neurons, transgenic mice were generated in which rat clusterin transgene was expr...

journal_title：Journal of cell science

authors： Jomary C,Chatelain G,Michel D,Weston A,Neal MJ,Jones SE

更新日期：1999-05-01 00:00:00

abstract：:Activator of G-protein signaling 3 (AGS3, also known as GPSM1) regulates the trans-Golgi network. The AGS3 GoLoco motif binds to Gαi and thereby regulates the transport of proteins to the plasma membrane. Compaction of early embryos is based on the accumulation of E-cadherin (Cdh1) at cell-contacted membranes. However...

journal_title：Journal of cell science

authors： Nie ZW,Niu YJ,Zhou W,Zhou DJ,Kim JY,Cui XS

更新日期：2020-12-07 00:00:00

abstract：:Successful implantation requires the synchronization of viable embryonic development with endometrial receptivity. The mechanisms allowing for the initiation of crosstalk between the embryo and the endometrium remain elusive; however, recent studies have revealed that there are alterations in endometrial microRNAs (mi...

journal_title：Journal of cell science

authors： Kang YJ,Lees M,Matthews LC,Kimber SJ,Forbes K,Aplin JD

更新日期：2015-02-15 00:00:00

abstract：:The movement of cells in small groups, or clusters, was studied in vitro using epithelioid cells from Gordon-Kosswig melanomas (from poecelid fish) and time-lapse cinemicrography. Tumour explants cultured on glass yield cell sheets from which groups of cells separate and become independently motile clusters. These clu...

journal_title：Journal of cell science

authors： Kolega J

更新日期：1981-06-01 00:00:00

abstract：:Although the anti-apoptotic activity of Bcl-2 has been extensively studied, its mode of action is still incompletely understood. In the nematode Caenorhabditis elegans, 131 of 1090 somatic cells undergo programmed cell death during development. Transgenic expression of human Bcl-2 reduced cell death during nematode de...

journal_title：Journal of cell science

authors： Jabbour AM,Puryer MA,Yu JY,Lithgow T,Riffkin CD,Ashley DM,Vaux DL,Ekert PG,Hawkins CJ

更新日期：2006-06-15 00:00:00

abstract：:Voltage-gated Ca2+ (CaV) channels couple membrane depolarization to Ca2+ influx, triggering a range of Ca2+-dependent cellular processes. CaV channels are, therefore, crucial in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many neurotransmitters an...

journal_title：Journal of cell science

authors： Mustafá ER,López Soto EJ,Martínez Damonte V,Rodríguez SS,Lipscombe D,Raingo J

更新日期：2017-11-15 00:00:00

abstract：:The nature, intracellular distribution, and role of proteins synthesized during meiotic maturation of mouse oocytes in vitro have been examined. Proteins synthesized during the initial stages of maturation are concentrated within the nucleus (germinal vesicle) and become intimately associated with the condensing chrom...

journal_title：Journal of cell science

authors： Wassarman PM,Letourneau GE

更新日期：1976-05-01 00:00:00

abstract：:5'AMP nucleotidase activity was localized by electron microscopy in Dictyostelium discoideum during cell differentiation. In addition, the activity was assayed by micro enzymic methods in sections dissected from specific cellular regions of lyophilized individuals. The results of the 2 procedures were in agreement, de...

journal_title：Journal of cell science

authors： Armant DR,Stetler DA,Rutherford CL

更新日期：1980-10-01 00:00:00

abstract：:The Arabidopsis AINTEGUMENTA (ANT) gene, which encodes an APETALA2 (AP2)-like transcription factor, controls plant organ cell number and organ size throughout shoot development. ANT is thus a key factor in the development of plant shoots. Here, we have found that ANT plays an essential role in conferring salt toleranc...

journal_title：Journal of cell science

authors： Meng LS,Wang YB,Yao SQ,Liu A

更新日期：2015-08-01 00:00:00

abstract：:The ret finger protein (rfp) is a member of the B box zinc finger gene family which possesses a tripartite motif consisting of a RING finger, B box finger, and a coiled-coil domain. Rfp is expressed at specific stages of spermatogenesis and in various adult mouse and human tissues. It becomes oncogenic when the tripar...

journal_title：Journal of cell science

authors： Cao T,Borden KL,Freemont PS,Etkin LD

更新日期：1997-07-01 00:00:00

abstract：:T cell activation is accompanied by actin-mediated receptor clustering and reorganization of lipid rafts. It has been suggested that costimulatory molecules might be involved in these processes. We here provide evidence that engagement of the adhesion molecule CD44 initiates cytoskeletal rearrangement and membrane reo...

journal_title：Journal of cell science

authors： Föger N,Marhaba R,Zöller M

更新日期：2001-03-01 00:00:00

abstract：:The presence of an acetolysis-resistant polymer (sporopollenin) in the cellular slime moulds is demonstrated. This polymer is located on the stalk sheath of fruiting bodies as a bundle of fine fibrils (4-5 nm diameter). The location and structure of sporopollenin in spores are shown to vary considerably, depending upo...

journal_title：Journal of cell science

authors： Maeda Y

更新日期：1984-03-01 00:00:00

abstract：:We investigated mechanisms of the p73alpha-mediated repression of the platelet-derived growth factor beta-receptor (PDGFRB) promoter caused by its interaction with NF-Y. Treatment of cells with the histone deacetylase (HDAC) inhibitor, Trichostatin A, increases PDGFRB promoter activity through the CCAAT motif and coun...

journal_title：Journal of cell science

authors： Uramoto H,Wetterskog D,Hackzell A,Matsumoto Y,Funa K

更新日期：2004-10-15 00:00:00

abstract：:Entry into mitosis requires p34(cdc2), which activates downstream mitotic events through phosphorylation of key target proteins. In Aspergillus nidulans, the NIMA protein kinase has been identified as a potential downstream target and plays a role in regulating chromatin condensation at mitosis. nimA- mutants arrest i...

journal_title：Journal of cell science

authors： Krien MJ,Bugg SJ,Palatsides M,Asouline G,Morimyo M,O'Connell MJ

更新日期：1998-04-01 00:00:00

abstract：:Pieces of small intestine from newborn, I- and 6-day-old piglets were incubated in vitro and ligated segments were incubated in vivo with polycationic ferritin (PCF) to determine the distribution and possible role in protein uptake of anionic sites on membranes at the luminal surfaces of the epithelial cells. Most PCF...

journal_title：Journal of cell science

authors： Chase CC,Munn EA

更新日期：1980-12-01 00:00:00

abstract：:The forkhead transcription factor FOXN1 is required for normal cutaneous and thymic epithelial development. Mutations in FOXN1 give rise to the nude phenotype in mice, rats and man. However, the genes that are regulated by FOXN1 are unknown. To investigate FOXN1 function we expressed an inducible form of the protein, ...

journal_title：Journal of cell science

authors： Janes SM,Ofstad TA,Campbell DH,Watt FM,Prowse DM

更新日期：2004-08-15 00:00:00

abstract：:Regulation of the localization of mRNAs and local translation are universal features in eukaryotes and contribute to cellular asymmetry and differentiation. In Saccharomyces cerevisiae, localization of mRNAs that encode membrane proteins requires the She protein machinery, including the RNA-binding protein She2p, as w...

journal_title：Journal of cell science

authors： Hermesh O,Genz C,Yofe I,Sinzel M,Rapaport D,Schuldiner M,Jansen RP

更新日期：2014-08-01 00:00:00

abstract：:Transcription factor IIH (TFIIH) participates in transcription, nucleotide excision repair and the control of the cell cycle. In the present study, we demonstrate that the Dmp52 subunit of TFIIH in Drosophila physically interacts with the fly p53 homologue, Dp53. The depletion of Dmp52 in the wing disc generates chrom...

journal_title：Journal of cell science

authors： Villicaña C,Cruz G,Zurita M

更新日期：2013-06-01 00:00:00