Abstract:
OBJECTIVES:The cellular basis of painful tendon overuse pathology (tendinosis) is poorly understood. It has been suggested that because of the close anatomical associations between mast cells and vessels in connective tissues, mast cells may mediate the development of tendon hypervascularity or oedema. OBJECTIVES:To examine the distribution of mast cells in men and women with patellar tendinopathy. DESIGN:Case-control study. METHODS:Tendinopathic tissue was collected at open debridement of the patellar tendon and a control tendon from patients undergoing intramedullary nailing of the tibia. The tendon was assessed immunohistochemically by evaluating the distribution of mast cells (AA1), and markers for T lymphocytes (CD3) and macrophages (CD68). The vessel-area fraction was quantified using computer-assisted digital image analysis. RESULTS:The prevalence of mast cells per mm(2) (mean 3.3 (SD 3.0)) was greater in tendinosis tissue than in controls (1.1 (1.5); p = 0.036). In patients with tendinosis, mast cell density was moderately correlated with the vessel-area fraction (r(2) = 0.49) and with symptom duration (r(2) = 0.52). CONCLUSION:Mast-cell prevalence in patellar tendinopathy was increased and was predominantly associated with vascular hyperplasia, particularly in patients with longstanding symptoms. Future research should investigate whether mast cells play direct or indirect modulatory roles in the development and progression of human tendinosis.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
Scott A,Lian Ø,Bahr R,Hart DA,Duronio V,Khan KMdoi
10.1136/bjsm.2007.040212subject
Has Abstractpub_date
2008-09-01 00:00:00pages
753-7issue
9eissn
0306-3674issn
1473-0480pii
bjsm.2007.040212journal_volume
42pub_type
杂志文章abstract::Evidence from familial and genetic association studies have reported that DNA sequence variants play an important role, together with non-genetic factors, in the aetiology of both exercise-associated and occupational-associated acute and chronic musculoskeletal soft tissue injuries. The associated variants, which have...
journal_title:British journal of sports medicine
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pub_type: 杂志文章,评审
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更新日期:1983-03-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-12-01 00:00:00
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更新日期:2006-05-01 00:00:00
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更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00