Abstract：
OBJECTIVES:The objectives of this study were to evaluate and to compare the glycemic control of various antidiabetic agents and the role of homocysteine in type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS:Two hundred forty patients with type 2 diabetes mellitus, divided into Groups 1-6 (n=40), received glipizide, glipizide-SR, glimepiride, glibenclamide, metformin, and insulin followed by an oral hypoglycemic agent, respectively. They were evaluated with respect to glycemic control, serum insulin, safety, and quality of life (QoL) for 24 weeks. Furthermore, poorly controlled patients with elevated serum homocysteine were divided into two groups, of which received folic acid for 4 weeks. RESULTS:Glipizide-SR significantly improved glycemic control at lower serum insulin levels, was well tolerated, and improved QoL. Metformin improved glycemic control and reduced insulin resistance in obese type 2 diabetes mellitus patients. Initial insulin therapy led to rapid reduction in hyperglycemia with reduced insulin resistance. Folic acid therapy significantly (P<.001) lowered elevated serum homocysteine levels in poorly controlled patients. CONCLUSIONS:Glipizide-SR emerged as the sulfonylurea of choice in lean type 2 diabetes mellitus patients, while metformin was preferable for obese type 2 diabetes mellitus patients. Short-course insulin therapy with subsequent oral hypoglycemic agent could obviate the need for continuous insulin therapy in poorly controlled type 2 diabetes mellitus patients. Folic acid constitutes an inexpensive and safe therapy for hyperhomocysteinemia in patients with type 2 diabetes mellitus.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Yegnanarayan R,Suryavanshi M,Singh M,Desai Sdoi
10.1016/j.jdiacomp.2006.09.001subject
Has Abstractpub_date
2008-03-01 00:00:00pages
104-11issue
2eissn
1056-8727issn
1873-460Xpii
S1056-8727(06)00094-8journal_volume
22pub_type
杂志文章abstract：:Table 1 shows how the five major drug groups interact with those variables which should be especially considered when treating the hypertensive diabetic. While diuretics are sometimes required in severely hypertensive cases-particularly when fluid retention is part of the clinical picture, and beta blockers are the ou...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/1056-8727(96)00030-X
更新日期：1996-05-01 00:00:00
abstract：:Diabetes mellitus (DM) can lead to the development of macro- and microvascular complications. Homocysteine (Hcy) may play a role in the development of cardiovascular (CV) diseases (CVDs). The role of Hcy in the development of the vascular complications associated with DM is not clearly defined. Despite a strong initia...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2020.107834
更新日期：2020-12-31 00:00:00
abstract：INTRODUCTION:Diabetic polyneuropathy aetiology is based on oxidative stress generation due to production of reactive oxygen species. Ubiquinone is reduced to ubiquinol and redistributed into lipoproteins, possibly to protect them from oxidation. AIMS:To evaluate the impact of oral ubiquinone in diabetic polyneuropathy...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdiacomp.2012.04.004
更新日期：2012-07-01 00:00:00
abstract：:There has been a substantial evolution of concepts related to disordered gastric emptying in diabetes. While the traditional focus has hitherto related to the pathophysiology and management of upper gastrointestinal symptoms associated with gastroparesis, it is now apparent that the rate of gastric emptying is central...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2014.06.005
更新日期：2014-11-01 00:00:00
abstract：AIMS:To evaluate whether increased urinary orosomucoid excretion rate (UOER) is an independent predictor of cardiovascular and all-cause mortality in type 2 diabetes (T2DM) and type 1 diabetes (T1DM) at 10years of follow-up. METHOD:We followed 430 patients with T2DM and 148 patients with T1DM until emigration, death o...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2013.05.008
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Metabolic Syndrome (MetS) is a cardio-metabolic cluster that confers an increased risk of developing both diabetes and atherosclerotic cardiovascular disease (ASCVD). The mechanisms governing the increased ASCVD risk remains to be elucidated. Moreover, lipidomics poses as an exciting new tool that has potent...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2018.05.014
更新日期：2018-08-01 00:00:00
abstract：:Since the discovery of the hepatitis C virus (HCV) in 1989, attention has been paid to the association of chronic HCV infection and the development of diabetes. The risk factors for diabetes include older age, HCV genotype 3, severe liver fibrosis, family history of diabetes, and liver/kidney transplantation. Emerging...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2006.01.001
更新日期：2006-03-01 00:00:00
abstract：AIM:To evaluate the efficacy, safety, and tolerability of multiple doses of ipragliflozin. This novel selective inhibitor of sodium glucose co-transporter 2 is in clinical development for the treatment of patients with type 2 diabetes mellitus (T2DM). METHODS:In a 12-week, multicenter, double-blind, randomized, active...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jdiacomp.2012.11.005
更新日期：2013-05-01 00:00:00
abstract：AIMS:The objective of this study was to evaluate diabetes-related healthcare resource use and associated costs in patients with type 2 diabetes (T2DM) treated with a sulfonylurea (SU), with and without hypoglycemia. METHODS:In this retrospective cohort study, patients 18years or older receiving SU monotherapy or as ad...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.07.012
更新日期：2017-11-01 00:00:00
abstract：:In order to elucidate the role of macrophage in lipid-induced nephrotoxicity in diabetic nephropathy, we examined the effect of macrophage colony-stimulating factor (M-CSF) on the progression of renal lesions in hypercholesterolemic steptozotocin (STZ)-diabetic rats fed with high cholesterol chow. Hypercholesterolemia...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/1056-8727(95)80025-a
更新日期：1995-10-01 00:00:00
abstract：AIMS:The efficacy of the once-daily prandial GLP-1 receptor agonist lixisenatide plus basal insulin in T2DM was assessed by pooling results of phase III trials. METHODS:A meta-analysis was performed of results from three trials in the GetGoal clinical program concerning lixisenatide or placebo plus basal insulin with/...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,meta分析
doi：10.1016/j.jdiacomp.2014.07.007
更新日期：2014-11-01 00:00:00
abstract：AIMS:To assess the association between dipstick hematuria and estimated glomerular filtration rate (eGFR) decline in Japanese patients with type 2 diabetes. METHODS:Longitudinal data were obtained from 3068 Japanese patients with type 2 diabetes. To assess the independent association between dipstick hematuria and eGF...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.04.016
更新日期：2017-07-01 00:00:00
abstract：AIM:Investigate contributors to treatment satisfaction in type 1 diabetes (T1D). METHODS:Post-hoc analysis using the Diabetes Treatment Satisfaction Questionnaire status version (DTSQs) in 771 T1D patients from two 28-week trials comparing once-daily insulin glargine 100U/mL (Gla-100) with once- or twice-daily NPH neu...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.11.018
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:To systematically investigate the effect of lack of adherence to the recommended change in insulin pump infusion line use beyond 48 h and determine whether the type of insulin made a difference. RESEARCH DESIGN AND METHODS:This was a double-blind, randomized, crossover trial with 20 patients with diabetes me...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdiacomp.2009.03.002
更新日期：2010-03-01 00:00:00
abstract：:Although the etiology of diabetic neuropathic pain remains enigmatic, two types of neuropathic pain are now recognized: nerve trunk pain following a discrete often vascular lesion as seen in ocular mononeuropathy and hyperalgesic pain as seen in diffuse involvement of peripheral sensory fibers. Our understanding of th...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/1056-8727(92)90050-u
更新日期：1992-01-01 00:00:00
abstract：:Plasma semicarbazide-sensitive amine oxidase (SSAO) and angiotensin-converting enzyme (ACE) were studied for their correlation with diabetes (DM) complication. The effect of interaction between SSAO and ACE in DM complication is of interest. Studying the functional change due to interaction between SSAO and ACE is dif...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2007.02.007
更新日期：2008-11-01 00:00:00
abstract：:Type 2 diabetes mellitus (T2DM) significantly increases morbidity and mortality from cardiovascular disease (CVD). Treatments for patients with T2DM have the potential to reduce cardiovascular (CV) risk. This review focuses on the potential of a new class of antidiabetic agents, the sodium glucose cotransporter 2 (SGL...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2012.12.004
更新日期：2013-05-01 00:00:00
abstract：:There is increasing evidence that glycemic disorders such as rapid glucose fluctuations over a daily period might play an important role on diabetic complications. We evaluated the efficacy of sitagliptin 100 mg once daily vs. vildagliptin 50 mg twice daily on daily blood glucose fluctuations in patients with type 2 d...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2009.01.004
更新日期：2010-03-01 00:00:00
abstract：AIM:The aims of this study are to investigate the relative regulation between miR-126 and VEGF/PI3K/AKT signaling pathway in retinal vascular endothelial cells. METHODS:Rhesus macaque choroid-retinal endothelial cell line (RF/6A) cells were cultured in high glucose to imitate the conditions occurring in DR. First, we ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.12.004
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Epigenetics modulated tissue-specific gene expression during the onset of type 1 and type 2 diabetes and their complications. METHODS:We searched the PubMed recent studies about the main epigenetic tags involved in type 1 and type 2 diabetes onset and their clinical complications. PubMed studies about the e...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2018.08.012
更新日期：2018-11-01 00:00:00
abstract：AIMS:To quantify the risk of hospitalization for infections in Indigenous Australian adults with diabetes in rural and remote communities. METHODS:2787 Indigenous adults including 396 with diabetes at baseline from 19 communities in North Queensland from 1998 to 2007 were included in the study. Main measures were weig...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.04.022
更新日期：2016-08-01 00:00:00
abstract：AIMS:Increased adiposity is a risk factor for suboptimal diabetes control and cardiovascular disease (CVD) complications. Our goal was to identify modifiable behavioral characteristics of overweight and obese pediatric patients with type 1 diabetes mellitus (T1DM) who achieve optimal glycemic control and to evaluate th...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2019.107513
更新日期：2020-04-01 00:00:00
abstract：AIM:A clinical appraisal of existing scientific literature sought to assess the need for long-term prospective epidemiological studies to investigate an increased cancer risk of anti-hyperglycemic medication in type 2 diabetes. METHOD:A focus statement was formulated as: "With a higher risk of cancers in patients with...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2017.06.003
更新日期：2017-09-01 00:00:00
abstract：AIMS:To examine the effects of strict glycemic control on the birthweight of infants born to Japanese patients with early- or mid-to-late-detected gestational diabetes mellitus (ed- or md-GDM). METHODS:We retrospectively examined the characteristics of 101 patients with GDM who underwent guideline-based glycemic contr...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2021.107850
更新日期：2021-01-09 00:00:00
abstract：:Myo-inositol oxygenase (MIOX) is the first and rate-limiting enzyme in myo-inositol (MI) metabolism pathway. The increase in MIOX enzyme activity is in proportion to serum glucose concentrations and may be responsible for the MI depletion found in the diabetic complications. The aim was to investigate whether single n...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2009.09.005
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:Although diabetic kidney disease (DKD) has been considered as a glomerulocentric disease in the past few decades, growing evidence demonstrated that tubular damage was indispensable in its pathogenesis and progression. This study was designed to investigate the association of urinary acidification dysfunction...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2019.107419
更新日期：2019-11-01 00:00:00
abstract：:Hypomagnesemia is common in diabetic subjects, and is especially common in poorly controlled diabetes, suggesting that diabetes low serum magnesium status is osmotic diuresis-dependent. To assess the relationship between serum magnesium and HDL-cholesterol concentration adjusted by serum glucose values. We assessed th...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(00)00127-6
更新日期：2000-09-01 00:00:00
abstract：AIMS:The cardiovascular risk factors and diabetic complications are related to coronary atherosclerosis. However, the evaluation of the prevalence of coronary atherosclerosis based on their accumulation remains to be determined. METHODS:247 consecutive Chinese subjects with type 2 diabetes but without history of coron...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.12.019
更新日期：2016-04-01 00:00:00
abstract：:Endothelin (ET)-1 has been implicated in the pathogenesis of diabetes, arteriosclerosis, and chronic renal failure. We studied whether low-density lipoprotein (LDL) apheresis alters plasma ET-1 levels in diabetic hemodialysis patients with arteriosclerosis obliterans (ASO). Plasma ET-1 levels were measured in 30 healt...
journal_title：Journal of diabetes and its complications
pub_type： 临床试验,杂志文章
doi：10.1016/s1056-8727(02)00171-x
更新日期：2003-11-01 00:00:00
abstract：AIM:To examine the diabetes self-care behaviors of Filipino-American (FA) adults with type 2 diabetes mellitus (DM). METHOD:The Summary of Diabetes Self Care Activities-Revised and Expanded measure was administered to 192 (74 males and 118 females) FA adult immigrants with type 2 DM. RESULTS:Older FAs (> or =65 years...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2009.03.006
更新日期：2010-07-01 00:00:00
