[Immune complexes in diabetes mellitus].

Abstract:

:Research in recent years has documented more exactly the genetic and immunopathogenetic basis of insulin-dependent diabetes mellitus. Also, in some genetically susceptible subjects, a triggering event activates both cellular and humoral immunity, with diminishing of b cellular mass. Early intervention to prevent diabetes development as well as to prevent microvascular complications is identification of individuals in whom autoimmunity has been activated. One of the non-specific tests is a screening test for the detection of circulating immune complexes /CIC/ by precipitating tests using polyethylene glycol it was performed in series of healthy, insulin-dependent and non-insulin dependent diabetic subjects. Highly increased precitability was seen in a great percentage of pathological sera. In spite of the non-specific method for immune complexes detection, positive results obtained by PEG method generally presumed that diabetes represent immune complex disease.

journal_name

Srp Arh Celok Lek

authors

Kocić R,Radenković S,Milenović M,Mijailović M,Koraćević G,Zivić S,Pesić M,Kosić G

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

60-3

eissn

0370-8179

issn

2406-0895

journal_volume

122 Suppl 1

pub_type

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