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Objective analysis of whole lung and lobar ventilation/perfusion relationships in pulmonary embolism.

Abstract：

PURPOSE:Lung scintigraphy using single photon emission computed tomography (SPECT) allows accurate regional measurement of the ventilation/perfusion (V/Q) relationship. Objective V/Q analysis has been shown to be useful in the diagnosis of pulmonary embolism (PE). By using anatomical information provided by co-registered computed tomography, we describe methodology for determining the extent of V/Q heterogeneity at a lobar level. We investigate this methodology using simulated data, and demonstrate its potential application in the clinical setting of PE. METHODS:Data representing an incremental perfusion defect involving the right lung, together with an unaffected ventilation dataset, were modelled using Monte Carlo simulation. For each increase in the size of the perfusion defect, the whole lung V/Q relationship was objectively determined. In addition, using an image mask of the pulmonary lobes, lobar V/Q relationships were also determined. V/Q heterogeneity was characterized using the log(10) standard deviation of the V/Q ratio (log SDVQR), ventilation (log SDV) and perfusion (log SDQ) distributions. Finally, this methodology was explored in clinical cases. RESULTS:As an increasing number of segments were involved by perfusion defects, there was a progressive increase in all objective parameters of V/Q heterogeneity. The relative change was greatest for log SDV. Analysis of both the simulated and clinical studies demonstrated sensitive changes in the lobar V/Q profiles to the presence of PE. CONCLUSIONS:Segmentation and analysis of SPECT ventilation-perfusion scintigraphy at a lobar level can be used to quantify regional V/Q relationships. This objective methodology is sensitive to the presence of PE, and may be useful in a clinical setting.

journal_name

Clin Physiol Funct Imaging

journal_title

Clinical physiology and functional imaging

authors

Harris B,Bailey DL,Chicco P,Bailey EA,Roach PJ,King GG

doi

10.1111/j.1475-097X.2007.00767.x

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

14-26

issue

eissn

1475-0961

issn

1475-097X

pii

CPF767

journal_volume

pub_type

杂志文章

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Objective analysis of whole lung and lobar ventilation/perfusion relationships in pulmonary embolism.