Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes.

Abstract:

:Juvenile diabetics have severe loss of beta cell function and require replacement therapy with insulin. Insulin antigenicity can produce anti-insulin antibodies resulting in allergic reactions and insulin resistance. The role of insulin-anti-insulin antibody complexes in the development and progress of chronic diabetic complications like microangiopathy is not very clear. In the present study, there was statistically a significant trend of higher insulin antibody binding levels in IDDM patients who developed retinopathy. Though there was a trend of higher insulin antibody in IDDM patients with retinopathy, there was no association between insulin antibody and HLA antigen which some authors have reported.

journal_name

Indian J Ophthalmol

authors

Sharma K,Khosla PK,Tiwari HK,Sharma RK,Bajaj JS

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

174-5

issue

4

eissn

0301-4738

issn

1998-3689

journal_volume

39

pub_type

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