Abstract:
:This study was aimed to obtain additional information on the activity of a cyclized 9-amino acid peptide (cP) containing the active site of alpha fetoprotein, which inhibits the estrogen-stimulated proliferation of tumor cells in culture and of xenografts in immunodeficient mice. Breast cancer cells cultured in the presence of 2 nM estradiol were exposed to cP for different periods and their proliferation, estradiol binding parameters, clustering tendency and expression of E-cadherin and p21Cip1 were analyzed by biochemical and cell biology methods. The proliferation of MCF7 cells was significantly decreased by the addition of 2 microg/ml cP to the medium. cP did not increase cell death rate nor alter the number of binding sites for estradiol nor the endogenous aromatase activity of MCF7 cells. cP also decreased the proliferation of estrogen-dependent ZR75-1 cells but had no effect on estrogen-independent MDA-MB-231 cells. An increased nuclear p21Cip1 expression detected after cP treatment suggests that cP slows MCF7 cell proliferation via this regulator. We propose that cP could represent a novel breast cancer therapeutic agent whose mechanism of action is different from that of tamoxifen or of inhibitors of aromatase.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Sierralta WD,Epuñan MJ,Reyes JM,Valladares LE,Andersen TT,Bennett JA,Jacobson HI,Pino AMsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
229-35issue
1eissn
1021-335Xissn
1791-2431journal_volume
19pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Glioblastoma is a highly angiogenic tumor with a dismal prognosis. Temozolomide (TMZ), a methylating agent is one of the most effective chemotherapeutic agents against glioblastoma. To overcome the problem that most of these tumors become resistant to chemotherapeutic regimens within a year, we investigated the antitu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::X-ray-based radiotherapy is one of the most effective therapeutic strategies for breast cancer patients. However, radioresistance and side-effects continue to be the most challenging issues. B-cell translocation gene 1 (BTG1) is a member of the BTG/Tob family, which inhibits cancer growth and promotes apoptosis. We, t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4311
更新日期:2015-12-01 00:00:00
abstract::Neuroblastoma is the most common inheritable, solid neoplasm in children found under the age of 7 and accounts for approximately 7% of childhood cancers. A common treatment that has been prescribed for over a decade is retinoid therapy [using all‑trans retinoic acid (RA)]. Treatment with this differentiating agent has...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7681
更新日期:2020-09-01 00:00:00
abstract::The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9.1 were determined in 112 paired clinical GA tissues by reverse transcription‑q...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7127
更新日期:2019-06-01 00:00:00
abstract::By combining suppression subtractive hybridization and microarray to examine gene expressions between metastatic and non-metastatic non-small cell lung cancer (NSCLC), we have identified differential expression spectra of matrix metalloproteinases (MMP). Among MMPs, expressions of MMP-13, -14, -15 and -24 decreased, t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::Lapatinib, an inhibitor of human epidermal growth factor receptor 2 (HER2) phosphorylation, has been reported to inhibit several types of tumors such as HER2-overexpressing breast cancer. However, the effect of lapatinib on the malignant phenotype of human osteosarcoma (OS) cells and the potential molecular mechanisms...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2825
更新日期:2014-01-01 00:00:00
abstract::A crucial step in the path to the malignant transformation of cells and tumor formation is immortalization, which essentially depends on telomere maintenance. The aim of this study was to investigate the role of telomerase in the progression of Barrett's esophagus. Telomerase activi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2238
更新日期:2013-04-01 00:00:00
abstract::Progestin and adipoQ receptor family member III (PAQR3) is a regulator that negatively modulates the Ras/Raf/MEK/ERK signaling cascade and the GPCR Gβγ subunit signaling pathway. The role of PAQR3 in hepatocellular carcinoma (HCC) has not been elucidated. The present study investigated the expression of PAQR3 and its ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3532
更新日期:2014-12-01 00:00:00
abstract::In the present study, we investigated the role of lysyl oxidase‑like 2 (LOXL2), the correlation between LOXL2 and epithelial to mesenchymal transition (EMT) and the effects of using β‑aminopropionitrile (BAPN) to inhibit LOXL2 with the aim of reducing tumor progression in hepatocellular carcinoma (HCC). The expression...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6349
更新日期:2018-06-01 00:00:00
abstract::Signal transducer and activator of transcription (STAT) 5, including STAT 5a and STAT 5b, was reported to play important roles in the malignant biological behaviors of tumors. However, their roles in gastric cancer, especially for STAT 5b remain unknown. This study aimed to detect the expression of STAT 5b in gastric ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3994
更新日期:2015-07-01 00:00:00
abstract::Orotate phosphoribosyl transferase (OPRT) is the initial enzyme of 5-fluorouracil (5-FU) activation, in which 5-FU is converted to 5-fluorouridinemonophosphate. Dihydropyrimidine dehydrogenase (DPD) is a degrading enzyme that catabolizes 5-FU. In this study, we investigated the expression of these enzymes in normal pr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). Twenty-five patients with cirrhosis that evolved into HCC, who were treated at The Third Hospital of Zhenjiang Affiliated to Jiangsu University between January 2005 and December 2012, were enroll...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3924
更新日期:2015-06-01 00:00:00
abstract::We performed methylation specific PCR to explore the mechanism of inactivation of tumor suppressor genes P15, P16, P53 and VHL in 48 oral SCC. The frequencies of aberrant methylation on the promoter of the P15, the P16, the P53 and the VHL genes were 0.27 (13/48), 0.42 (20/48), 0.04 (2/48) and none, respectively. Alto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5755
更新日期:2017-08-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a leading cause of cancer‑related morbidity and mortality globally. Despite the remarkable improvements in comprehensive HCC treatment, the underlying mechanistic details of HCC remain elusive. We screened HCC patients for differentially expressed genes (DEGs) using the Gene Expressio...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7779
更新日期:2020-11-01 00:00:00
abstract::In this work we studied the effect of v-raf and different form RAF on up regulation of VEGF gene expression and angiogenesis. In the experiments the truncated forms of RAF1 gene were transfected into the cells of the established human urothelial line HCV-29, otherwise non-angiogenic. The plasmids coding for mitochondr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Gallbladder cancer (GBC) is a rare disease associated with an extremely poor patient prognosis, and occasionally, aberrant expression of p53 is present. Considering that p53 is one of the most widely studied tumor‑suppressor genes, we used a cell-penetrating peptide, 11R, to enhance the transferring efficiency of the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2511
更新日期:2013-08-01 00:00:00
abstract::The promigratory molecule L1CAM is overexpressed in various tumors, often representing an unfavorable prognostic marker. Recently, we identified L1CAM expression in pancreatic ductal adenocarcinoma (PDAC) cells accounting for chemoresistance and increased cell migration. Thus, the present study aims at further elucida...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2010.909
更新日期:2010-10-01 00:00:00
abstract::Apoptosis repressor with caspase recruitment domain (ARC), an inhibitor of apoptosis, is primarily expressed in terminally differentiated tissues. Recent studies have revealed that ARC is highly expressed in a variety of human cancer cell lines and epithelial-derived cancers, which suggests that ARC plays an important...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2622
更新日期:2013-10-01 00:00:00
abstract::Autophagy is an intracellular multi-step catabolic degradation process that involves the degradation and recycling of cellular proteins and cytoplasmic damaged organelles to maintain cellular homeostasis and reduction of metabolic stress. Numerous studies have indicated the importance of autophagy in cancer, but the r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4302
更新日期:2015-12-01 00:00:00
abstract::Cancer immunotherapy is a promising new approach to cancer treatment. It has been demonstrated that a high number of tumor-specific cytotoxic T cells (CTLs) is associated with increased disease-specific survival in lung cancer patients. Identification of superior CTL epitopes from tumor antigens is essential for the d...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3198
更新日期:2014-07-01 00:00:00
abstract::In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and do...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2749
更新日期:2013-12-01 00:00:00
abstract::Melanoma is the most aggressive cutaneous cancer due to its propensity to metastasise and proliferate. Melanoma accounts for 80‑90% of skin‑cancer related deaths worldwide. Alhough numerous published studies have attempted to define the markers of diagnosis and prognosis of melanoma, a sensitive and specific biomarker...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6356
更新日期:2018-06-01 00:00:00
abstract::Epithelial ovarian cancer (EOC) is the most common cause of gynecological cancer-related mortality. Clear cell EOC (cEOC) has a number of clinical features distinguishing it from other EOC because of frequent concurrence of endometriosis and highly chemoresistant nature resulting in a poor prognosis. Recent biochemica...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or_00000750
更新日期:2010-05-01 00:00:00
abstract::During the initial emergency operation, a temporary loop colostomy (TLC) was constructed at the oral border of the region for subsequent radical resection. Then, radical surgery was performed by hybrid 2-port HALS (Mukai's operation) using the TLC as the hand access site. Left hemicolectomy was done in three patients,...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000824
更新日期:2010-07-01 00:00:00
abstract::Despite improvements in immunotherapy, little is known about dendritic cell (DC) subpopulations naturally occurring in the laryngeal cancer tissue (LCT) and peripheral blood (PB) of untreated laryngeal cancer (LC) patients. The purpose of the present study was to evaluate mature, im...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1754
更新日期:2012-07-01 00:00:00
abstract::A novel core‑shell type thermo‑nanoparticle (CSTNP) co‑loaded with temozolomide (TMZ) and the fluorescein new indocyanine green dye IR820 (termed IT‑CSTNPs) was designed and combined with a near‑infrared (NIR) laser to realize its photothermal conversion. The IT‑CSTNPs were prepared using a two‑step synthesis method a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7329
更新日期:2019-12-01 00:00:00
abstract::For deveplopment and function of the lung, progesterone (Prog) fulfils important roles. In a recent report, immunolocalization of Prog and estrogen receptors in non-small cell lung carcinomas were examined and it was shown that the Prog receptor might be a potent prognostic factor. In the present study, a cell line wi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract::The development of drug resistance represents a major complication in the effective treatment of breast cancer. Epigenetic therapy, through the use of histone deacetylase inhibitors (HDACi) or demethylation agents, is an emerging area of therapeutic targeting in a number of ontologi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1488
更新日期:2012-01-01 00:00:00
abstract::Gastric cancer is a common malignancy worldwide. The prognosis of early stage gastric cancer patients has significantly improved in recent years. However, in progressive stage gastric cancer patients, the prognosis remains relatively poor due to tumor metastases. In our previous study, we showed that the expression of...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6681
更新日期:2018-11-01 00:00:00