Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells.

abstract：:The recent completion of the deletion of essentially all of the ORFs in yeast is an important new resource for identifying the phenotypes of unknown genes. Each ORF is replaced with a cassette containing unique tag sequences that allow rapid parallel analysis of strains in a pool by using hybridization to a high-densi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birrell GW,Giaever G,Chu AM,Davis RW,Brown JM

更新日期：2001-10-23 00:00:00

abstract：:Four monoclonal anti-parathyroid antibodies were generated after immunization of mice with intact cells from human parathyroid tissue. All four monoclonal antibodies reacted in immunohistochemistry with structures present on parathyroid epithelial cells and proximal-tubule cells of the kidney but were unreactive with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Juhlin C,Holmdahl R,Johansson H,Rastad J,Akerström G,Klareskog L

更新日期：1987-05-01 00:00:00

abstract：:The rates of reassociation of DNA from a monkey cell line (Vero), from SV40 pseudovirus (consisting of Vero DNA and virus protein coat), and from mature SV40 were measured. The results show that the host DNA in the pseudovirus contains repeated and unique sequences in the same proportions as normal host DNA; hence, no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grady L,Axelrod D,Trilling D

更新日期：1970-12-01 00:00:00

abstract：:Many paleoredox proxies indicate low-level and dynamic incipient oxygenation of Earth's surface environments during the Neoarchean (2.8-2.5 Ga) before the Great Oxidation Event (GOE) at ∼2.4 Ga. The mode, tempo, and scale of these redox changes are poorly understood, because data from various locations and ages sugges...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koehler MC,Buick R,Kipp MA,Stüeken EE,Zaloumis J

更新日期：2018-07-24 00:00:00

abstract：:Kampo formulations are traditional herbal medications used in China and Japan for many centuries to treat diarrheal diseases such as cholera. Our studies were undertaken to identify and verify by chemical synthesis the active components that inhibited cholera toxin (CT), the virulence factor secreted by Vibrio cholera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oi H,Matsuura D,Miyake M,Ueno M,Takai I,Yamamoto T,Kubo M,Moss J,Noda M

更新日期：2002-03-05 00:00:00

abstract：:Sulfonated gallium(III) corroles are intensely fluorescent macrocyclic compounds that spontaneously assemble with carrier proteins to undergo cell entry. We report in vivo imaging and therapeutic efficacy of a tumor-targeted corrole noncovalently assembled with a heregulin-modified protein directed at the human epider...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agadjanian H,Ma J,Rentsendorj A,Valluripalli V,Hwang JY,Mahammed A,Farkas DL,Gray HB,Gross Z,Medina-Kauwe LK

更新日期：2009-04-14 00:00:00

abstract：:The osteopontin (Opn) glycoprotein has been implicated in diverse physiological processes, including vascularization, bone formation, and inflammatory responses. Studies of its role in immune responses has suggested that Opn can set the early stage of type-1 immune (cell-mediated) responses through differential regula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinohara ML,Jansson M,Hwang ES,Werneck MB,Glimcher LH,Cantor H

更新日期：2005-11-22 00:00:00

abstract：:By using single-molecule multiparameter fluorescence detection, fluorescence resonance energy transfer experiments, and newly developed data analysis methods, this study demonstrates directly the existence of three structurally distinct forms of reverse transcriptase (RT):nucleic acid complexes in solution. Single-mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothwell PJ,Berger S,Kensch O,Felekyan S,Antonik M,Wöhrl BM,Restle T,Goody RS,Seidel CA

更新日期：2003-02-18 00:00:00

abstract：:Membrane-associated and periplasmic proteins of Agrobacterium tumefaciens C-58 were compared with those from avirulent (nontumrigenic) derivative strains by slab and two-dimensional gel electrophoresis. Two proteins (Per-I and Per-2), with a molecular weight of 37,500 and 37,300, respectively, were detected in the sup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sonoki S,Kado CI

更新日期：1978-08-01 00:00:00

abstract：:The amount of information that can be stored in working memory is limited but may be improved with practice. The basis of improved efficiency at the level of neural activity is unknown. To investigate this question, we trained monkeys to perform a working memory task that required memory for multiple stimuli. Performa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang H,Qi XL,Riley MR,Constantinidis C

更新日期：2019-04-02 00:00:00

abstract：:Whereas 234(92)U142 and other actinon nuclei have ground-state bands that indicate that each nucleus consists of a sphere and a single revolving cluster with constant composition and with only a steady increase in the moment of inertia with increase in J, the angular-momentum quantum number, many of the lanthanon grou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1991-02-01 00:00:00

abstract：:Recent studies have shown that human cytomegalovirus (HCMV) can induce a robust increase in lipid synthesis which is critical for the success of infection. In mammalian cells the central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vysochan A,Sengupta A,Weljie AM,Alwine JC,Yu Y

更新日期：2017-02-21 00:00:00

abstract：:Direct structural insights on the fundamental mechanisms of permeation, selectivity, and gating remain unavailable for the Na(+) and Ca(2+) channel families. Here, we report the spectroscopic structural characterization of the isolated Voltage-Sensor Domain (VSD) of the prokaryotic Na(+) channel NaChBac in a lipid bil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakrapani S,Sompornpisut P,Intharathep P,Roux B,Perozo E

更新日期：2010-03-23 00:00:00

abstract：:Euarthropoda is one of the best-preserved fossil animal groups and has been the most diverse animal phylum for over 500 million years. Fossil Konservat-Lagerstätten, such as Burgess Shale-type deposits (BSTs), show the evolution of the euarthropod stem lineage during the Cambrian from 518 million years ago (Ma). The s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daley AC,Antcliffe JB,Drage HB,Pates S

更新日期：2018-05-22 00:00:00

abstract：:The term quantum turbulence denotes the turbulent motion of quantum fluids, systems such as superfluid helium and atomic Bose-Einstein condensates, which are characterized by quantized vorticity, superfluidity, and, at finite temperatures, two-fluid behavior. This article introduces their basic properties, describes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barenghi CF,Skrbek L,Sreenivasan KR

更新日期：2014-03-25 00:00:00

abstract：:There has been much confusion recently about the relative merits of different approaches, osmotic stress, preferential interaction, and crowding, to describe the indirect effect of solutes on macromolecular conformations and reactions. To strengthen all interpretations of measurements and to forestall further unnecess...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parsegian VA,Rand RP,Rau DC

更新日期：2000-04-11 00:00:00

abstract：:Without sufficient greenhouse gases in the atmosphere, the early Earth would have become a permanently frozen planet because the young Sun was less luminous than it is today. Several resolutions to this faint young Sun-frozen Earth paradox have been proposed, with an atmosphere rich in CO2 being the one generally favo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bada JL,Bigham C,Miller SL

更新日期：1994-02-01 00:00:00

abstract：:BALB/c mice immunized with syngeneic methylcholanthrene-induced fibrosarcomas did not have antibodies against the unique tumor-specific transplantation antigens, even though they were capable of rejecting a lethal dose of tumor cells. Endogenous murine leukemia virus antigens expressed by certain of the tumors did, ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JP,Klitzman JM,Hellström I,Nowinski RC,Hellström KE

更新日期：1978-02-01 00:00:00

abstract：:The majority of bacteria in the natural environment live within the confines of a biofilm. The Gram-positive bacterium Bacillus subtilis forms biofilms that exhibit a characteristic wrinkled morphology and a highly hydrophobic surface. A critical component in generating these properties is the protein BslA, which form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bromley KM,Morris RJ,Hobley L,Brandani G,Gillespie RM,McCluskey M,Zachariae U,Marenduzzo D,Stanley-Wall NR,MacPhee CE

更新日期：2015-04-28 00:00:00

abstract：:Tumor-specific molecules are needed across diverse areas of oncology for use in early detection, diagnosis, prognosis and therapy. Large and growing public databases of transcriptome sequencing data (RNA-seq) derived from tumors and normal tissues hold the potential of yielding tumor-specific molecules, but because th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrett CL,DeBoever C,Jepsen K,Saenz CC,Carson DA,Frazer KA

更新日期：2015-06-09 00:00:00

abstract：:Wnts regulate important intracellular signaling events, and dysregulation of the Wnt pathway has been linked to human disease. Here, we uncover numerous Wnt canonical effectors in human platelets where Wnts, their receptors, and downstream signaling components have not been previously described. We demonstrate that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steele BM,Harper MT,Macaulay IC,Morrell CN,Perez-Tamayo A,Foy M,Habas R,Poole AW,Fitzgerald DJ,Maguire PB

更新日期：2009-11-24 00:00:00

abstract：:There are two competing hypotheses for the origin of megaliths in Europe. The conventional view from the late 19th and early 20th centuries was of a single-source diffusion of megaliths in Europe from the Near East through the Mediterranean and along the Atlantic coast. Following early radiocarbon dating in the 1970s,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz Paulsson B

更新日期：2019-02-26 00:00:00

abstract：:Antibodies from three different lines of monoclonal hybridomas crossreact with both the beta subunit of spectrin and the 90-kDa peptide present in highly purified preparations of the heme-controlled eIF-2 alpha (initiation factor 2 alpha-subunit) kinase from rabbit reticulocytes. Antibodies from two of the three lines...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kudlicki W,Fullilove S,Kramer G,Hardesty B

更新日期：1985-08-01 00:00:00

abstract：:We have shown recently that the temporal order of antioxidant consumption in human blood plasma exposed to a constant flux of aqueous peroxyl radicals is ascorbate = protein thiols greater than bilirubin greater than urate greater than alpha-tocopherol and that detectable lipid peroxidation starts only after ascorbate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frei B,England L,Ames BN

更新日期：1989-08-01 00:00:00

abstract：:cGMP is a key regulatory molecule in visual transduction, integration of neuronal response to excitatory neurotransmitters, relaxation of smooth muscle, intestinal secretion of water and salt, and reabsorption of sodium and water in the distal tubules of the nephron. Some of these cellular functions are associated wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruth P,Wang GX,Boekhoff I,May B,Pfeifer A,Penner R,Korth M,Breer H,Hofmann F

更新日期：1993-04-01 00:00:00

abstract：:Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In five experiments, participants (n = 701) were shown two silhouett...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nummenmaa L,Glerean E,Hari R,Hietanen JK

更新日期：2014-01-14 00:00:00

abstract：:Epithelial growth factor-like 7 (EGFL7) is a protein that is secreted by endothelial cells and plays an important role in angiogenesis. Although EGFL7 is aberrantly overexpressed in solid tumors, its role in leukemia has not been evaluated. Here, we report that levels of both EGFL7 mRNA and EGFL7 protein are increased...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papaioannou D,Shen C,Nicolet D,McNeil B,Bill M,Karunasiri M,Burke MH,Ozer HG,Yilmaz SA,Zitzer N,Behbehani GK,Oakes CC,Steiner DJ,Marcucci G,Powell BL,Kolitz JE,Carter TH,Wang ES,Mrózek K,Croce CM,Caligiuri MA,Bl

更新日期：2017-06-06 00:00:00

abstract：:A serumless, chemically defined medium has been developed for the culture of oligodendrocytes isolated from primary neonatal rat cerebral cultures. Combined together, insulin, transferrin, and fibroblast growth factor synergistically induced an essentially homogenous population (95-98%) of cells expressing glycerol-3-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saneto RP,de Vellis J

更新日期：1985-05-01 00:00:00

abstract：:Nicotine exposure diminishes the protective breathing and arousal responses to stress (hypoxia). By exacerbating sleep-disordered breathing, this disturbance could underpin the well established association between smoking and the increased risk of sudden infant death syndrome. We show here that the protective response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen G,Han ZY,Grailhe R,Gallego J,Gaultier C,Changeux JP,Lagercrantz H

更新日期：2002-10-01 00:00:00

abstract：:Prompted by the increasing interest in networks in many fields, we present an attempt at unifying points of view and analyses of these objects coming from the social sciences, statistics, probability and physics communities. We apply our approach to the Newman-Girvan modularity, widely used for "community" detection, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bickel PJ,Chen A

更新日期：2009-12-15 00:00:00