Recent advances in the medical therapy of Crohn's disease in childhood.

Abstract:

:Crohn's disease (CrD) is characterised by an ongoing inflammatory response in the gut, in the absence of an obvious trigger. The treatment of CrD in children, during relapse and remission, requires special consideration of growth and development. This review addresses the use of present medical management strategies, including enteral nutrition, corticosteroids, immunosuppression and anti-TNF-alpha therapies. Anti-inflammatory IL-11 and leukocyte adhesion inhibitors have shown only moderate clinical efficacy in adults. Emerging treatments directed against the inflammatory cascade under investigation include inhibitors of IL-6 and -12, IFN-gamma and MAPKs. Probiotics and colony stimulating factors aim to stimulate the innate immune system. Research data from clinical trials are reviewed and summarised in respect of their potential within paediatric practice.

authors

Bremner AR,Beattie RM

doi

10.1517/14656566.8.15.2553

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

2553-68

issue

15

eissn

1465-6566

issn

1744-7666

journal_volume

8

pub_type

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