Abstract:
OBJECTIVE:To examine the possible pathological changes of the trigeminal vasculature in patients with neuralgia. BACKGROUND:Such a study has never been performed before. The alterations of the trigeminal vessels could have important pathophysiological implications in the trigeminal neuralgia pathogenesis. METHODS:The biopsy specimens for the electronmicroscopic (EM) and immunohistochemical examination were taken during a partial rhizotomy in 6 patients with trigeminal neuralgia and in 2 persons with trigeminal neuropathy. In addition, the 32 normal trigeminal nerves were used as the control specimens. RESULTS:The vascular pathological alterations were noticed in 3 out of 6 neuralgia patients. The EM study revealed signs of apoptosis or degeneration, respectively, of some endothelial and smooth muscle cells in the wall of the trigeminal arterioles. The immune reactions against CD31, CD34, and alpha-smooth muscle actin in these cells were weaker than in the control specimens, but stronger against factor VIII. In addition, the arteriolar basement membranes, which were thickened, showed an intense laminin, fibronectin, and collagen IV immunoreactivity. Similarly, some endothelial cells and pericytes of the intratrigeminal capillaries also showed signs of apoptosis or degeneration, respectively. Their basement membrane was very thick and showed an intense immune reaction against laminin, fibronectin, and collagen IV. CONCLUSION:The observed pathological changes of the trigeminal vasculature could be the primary factor, while demyelination of the trigeminal nerve fibers could be the secondary process in some patients with neuralgia.
journal_name
Headachejournal_title
Headacheauthors
Marinković S,Todorović V,Gibo H,Budec M,Drndarević N,Pesić D,Joković M,Cetković Mdoi
10.1111/j.1526-4610.2007.00933.xsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
1334-9issue
9eissn
0017-8748issn
1526-4610pii
HED933journal_volume
47pub_type
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