Regulatory and autoregulatory physiological dysfunction as a primary characteristic of post concussion syndrome: implications for treatment.

Abstract:

:Although most patients with concussion recover within days to weeks, a small but significant minority develop persistent signs and symptoms of post-concussion syndrome (PCS). The standard treatments of PCS, rest and cognitive adaptation, have limited effectiveness. PCS patients are advised not to exercise because of the concern for symptom exacerbation. Prolonged rest, however, leads to deconditioning (especially in athletes) and may cause secondary effects including depressive symptoms. Concussion is associated with metabolic and physiological changes in the brain and in other organ systems (for example, autonomic function of the heart and altered cerebral autoregulation, sleep, and circadian rhythms). We propose that PCS results from ongoing central and systemic physiologic regulatory dysfunction after traumatic brain injury (TBI) and we further propose that this physiologic dysfunction may be reduced or alleviated by individualized controlled sub-symptom threshold aerobic exercise rehabilitation.

journal_name

NeuroRehabilitation

journal_title

NeuroRehabilitation

authors

Leddy JJ,Kozlowski K,Fung M,Pendergast DR,Willer B

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

199-205

issue

3

eissn

1053-8135

issn

1878-6448

journal_volume

22

pub_type

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    doi:

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    更新日期:2002-01-01 00:00:00

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    journal_title:NeuroRehabilitation

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    更新日期:2003-01-01 00:00:00

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    authors: Struchen MA,Clark AN,Sander AM,Mills MR,Evans G,Kurtz D

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    doi:10.3233/NRE-172379

    authors: Spagnuolo G,Faria CDCM,da Silva BA,Ovando AC,Gomes-Osman J,Swarowsky A

    更新日期:2018-01-01 00:00:00

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    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:

    authors: Green P,Iverson GL

    更新日期:2001-01-01 00:00:00

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    pub_type: 杂志文章

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