Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L.

abstract：BACKGROUND:Epimorphic regeneration results in the restoration of lost tissues and structures from an aggregation of proliferating cells known as a blastema. Among amniotes the most striking example of epimorphic regeneration comes from tail regenerating lizards. Although tail regeneration is often studied in the contex...

journal_title：BMC developmental biology

authors： McLean KE,Vickaryous MK

更新日期：2011-08-16 00:00:00

abstract：BACKGROUND:After amputation of the Xenopus tadpole tail, a functionally competent new tail is regenerated. It contains spinal cord, notochord and muscle, each of which has previously been shown to derive from the corresponding tissue in the stump. The regeneration of the neural crest derivatives has not previously been...

journal_title：BMC developmental biology

authors： Lin G,Chen Y,Slack JM

更新日期：2007-05-24 00:00:00

abstract：BACKGROUND:Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in initiating the specification of the axis; the downstream events, however, are regulated by signal-tran...

journal_title：BMC developmental biology

authors： Gupta K,Pilli VS,Aradhyam GK

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:Retinal cell development has been extensively investigated; however, the current knowledge of dynamic morphological and molecular changes is not yet complete. RESULTS:This study was aimed at revealing the dynamic morphological and molecular changes in retinal cell development during the embryonic stages usi...

journal_title：BMC developmental biology

authors： Doh ST,Hao H,Loh SC,Patel T,Tawil HY,Chen DK,Pashkova A,Shen A,Wang H,Cai L

更新日期：2010-01-20 00:00:00

abstract：BACKGROUND:Despite the detailed knowledge obtained over the last decade on the molecular regulation of gastrulation in amniotes, the process of amnion development has been poorly described and illustrated in mice, and conflicting descriptions exist. Understanding the morphogenesis and development not only of the early ...

journal_title：BMC developmental biology

authors： Pereira PN,Dobreva MP,Graham L,Huylebroeck D,Lawson KA,Zwijsen AN

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The zinc finger transcription factor Egr-1 (Early growth response 1) is central to several growth factors and represents an important activator of target genes not only involved in physiological processes like embryogenesis and neonatal development, but also in a variety of pathophysiological processes, for ...

journal_title：BMC developmental biology

authors： Dussmann P,Pagel JI,Vogel S,Magnusson T,Zimmermann R,Wagner E,Schaper W,Ogris M,Deindl E

更新日期：2011-05-20 00:00:00

abstract：BACKGROUND:Real-time quantitative PCR is a sensitive and very efficient technique to examine gene transcription patterns in preimplantation embryos, in order to gain information about embryo development and to optimize assisted reproductive technologies. Critical to the successful application of real-time PCR is carefu...

journal_title：BMC developmental biology

authors： Goossens K,Van Poucke M,Van Soom A,Vandesompele J,Van Zeveren A,Peelman LJ

更新日期：2005-12-03 00:00:00

abstract：BACKGROUND:Cellularization of the Drosophila embryo is an unusually synchronous form of cytokinesis in which polarized membrane extension proceeds in part through incorporation of new membrane via fusion of apically-translocated Golgi-derived vesicles. RESULTS:We describe here involvement of the signaling enzyme Phosp...

journal_title：BMC developmental biology

authors： LaLonde M,Janssens H,Yun S,Crosby J,Redina O,Olive V,Altshuller YM,Choi SY,Du G,Gergen JP,Frohman MA

更新日期：2006-12-07 00:00:00

abstract：BACKGROUND:In chondrichthyans, basal osteichthyans and tetrapods, vertebral bodies have cartilaginous anlagen that subsequently mineralize (chondrichthyans) or ossify (osteichthyans). Chondrocytes that form the vertebral centra derive from somites. In teleost fish, vertebral centrum formation starts in the absence of c...

journal_title：BMC developmental biology

authors： Bensimon-Brito A,Cardeira J,Cancela ML,Huysseune A,Witten PE

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:The freshwater planarian Schmidtea mediterranea has emerged as a powerful model for studies of regenerative, stem cell, and germ cell biology. Whole-mount in situ hybridization (WISH) and whole-mount fluorescent in situ hybridization (FISH) are critical methods for determining gene expression patterns in pla...

journal_title：BMC developmental biology

authors： King RS,Newmark PA

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:Copines are calcium-dependent phospholipid-binding proteins found in diverse eukaryotic organisms. We are studying the function of copines in Dictyostelium discoideum, a single-celled amoeba that undergoes cell differentiation and morphogenesis to form multicellular fruiting bodies when placed in starvation ...

journal_title：BMC developmental biology

authors： Smith TS,Pineda JM,Donaghy AC,Damer CK

更新日期：2010-06-02 00:00:00

abstract：BACKGROUND:Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1. Recently, genetic defects of this pathway have been described, that lead to Cr deficiency, ...

journal_title：BMC developmental biology

authors： Braissant O,Henry H,Villard AM,Speer O,Wallimann T,Bachmann C

更新日期：2005-05-26 00:00:00

abstract：BACKGROUND:Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or function within the optic nerve. As a first step in understanding the role of HDACs in optic nerve, this s...

journal_title：BMC developmental biology

authors： Tiwari S,Dharmarajan S,Shivanna M,Otteson DC,Belecky-Adams TL

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:Germline stem cells (GSCs) are present in the gonads of Drosophila females and males, and their proper maintenance, as well as their correct differentiation, is essential for fertility and fecundity. The molecular characterization of factors involved in maintenance and differentiation is a major goal both in...

journal_title：BMC developmental biology

authors： Cash AC,Andrews J

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Circadian clocks have been implicated in the regulation of pre-adult development of fruit flies Drosophila melanogaster. It is believed that faster clocks speed up development and slower clocks slow it down. We established three sets of D. melanogaster populations (early, control and late). The early and lat...

journal_title：BMC developmental biology

authors： Kumar S,Vaze KM,Kumar D,Sharma VK

更新日期：2006-11-28 00:00:00

abstract：BACKGROUND:The Drosophila larval head is evolutionarily derived at the genetic and morphological level. In the beetle Tribolium castaneum, development of the larval head more closely resembles the ancestral arthropod condition. Unlike in Drosophila, a knirps homologue (Tc-kni) is required for development of the antenna...

journal_title：BMC developmental biology

authors： Peel AD,Schanda J,Grossmann D,Ruge F,Oberhofer G,Gilles AF,Schinko JB,Klingler M,Bucher G

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:The purpose of the study was an evaluation of fetal hip joint morphology during the second and the third trimester of pregnancy. Serial sections were performed on 23 cadaver infants. RESULTS:The mean lunar age was 6.6 months. Femoral shaft length (FSL) and width of the proximal and distal epiphysis were x-r...

journal_title：BMC developmental biology

authors： Masłoń A,Sibiński M,Topol M,Krajewski K,Grzegorzewski A

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:The persistence in adult teleost fish of retinal stem cells that exhibit all of the features of true 'adult stem cells'--self-renewal, multipotency, and the capacity to respond to injury by mitotic activation with the ability to regenerate differentiated tissues--has been known for several decades. However, ...

journal_title：BMC developmental biology

authors： Raymond PA,Barthel LK,Bernardos RL,Perkowski JJ

更新日期：2006-07-26 00:00:00

abstract：BACKGROUND:Work in other species suggests that interleukin-6 (IL6) promotes early embryo development. It was unclear whether IL6 serves as an embryokine in cultured bovine embryos. This work was undertaken to elucidate the role of IL6 during in vitro bovine embryo production. RESULTS:Transcripts for IL6 and its two co...

journal_title：BMC developmental biology

authors： Wooldridge LK,Ealy AD

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Astacins are a large family of zinc metalloproteases found in bacteria and animals. They have diverse roles ranging from digestion of food to processing of extracellular matrix components. The C. elegans genome contains an unusually large number of astacins, of which the majority have not been functionally c...

journal_title：BMC developmental biology

authors： Park JO,Pan J,Möhrlen F,Schupp MO,Johnsen R,Baillie DL,Zapf R,Moerman DG,Hutter H

更新日期：2010-01-28 00:00:00

abstract：BACKGROUND:MiR-9 is a small non-coding RNA that is highly conserved between species and primarily expressed in the central nervous system (CNS). It is known to influence proliferation and neuronal differentiation in the brain and spinal cord of different vertebrates. Different studies have pointed to regional and speci...

journal_title：BMC developmental biology

authors： Alwin Prem Anand A,Huber C,Asnet Mary J,Gallus N,Leucht C,Klafke R,Hirt B,Wizenmann A

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:Vertebrate neural development requires precise coordination of cell proliferation and cell specification to guide orderly transition of mitotically active precursor cells into different types of post-mitotic neurons and glia. Lateral inhibition, mediated by the Delta-Notch signaling pathway, may provide a me...

journal_title：BMC developmental biology

authors： Appel B,Givan LA,Eisen JS

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Neuroblastoma is a childhood cancer derived from immature cells of the sympathetic nervous system. The disease is clinically heterogeneous, ranging from neuronal differentiated benign ganglioneuromas to aggressive metastatic tumours with poor prognosis. Amplification of the MYCN oncogene is a well establishe...

journal_title：BMC developmental biology

authors： Henriksen JR,Haug BH,Buechner J,Tømte E,Løkke C,Flaegstad T,Einvik C

更新日期：2011-01-03 00:00:00

abstract：BACKGROUND:Mammalian spermatogenesis involves formation of haploid cells from the male germline and then a complex morphological transformation to generate motile sperm. Focusing on meiotic prophase, some tissue-specific transcription factors are known (A-MYB) or suspected (RFX2) to play important roles in modulating g...

journal_title：BMC developmental biology

authors： Horvath GC,Kistler MK,Kistler WS

更新日期：2009-12-09 00:00:00

abstract：BACKGROUND:Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, inflammation and endothelial tubulogenesis. Despite over a decade of research, no comprehensive in situ ...

journal_title：BMC developmental biology

authors： Padmakumar V,Masiuk KE,Luger D,Lee C,Coppola V,Tessarollo L,Hoover SB,Karavanova I,Buonanno A,Simpson RM,Yuspa SH

更新日期：2014-05-28 00:00:00

abstract：BACKGROUND:Tissue fixation is crucial for preserving the morphology of biological structures and cytological details to prevent postmortem degradation and autolysis. Improper fixation conditions could lead to artifacts and thus incorrect conclusions in immunofluorescence or histology experiments. To resolve reported st...

journal_title：BMC developmental biology

authors： Nie J,Mahato S,Zelhof AC

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:The FERM domain containing protein Mosaic Eyes (Moe) interacts with Crumbs proteins, which are important regulators of apical identity and size. In zebrafish, loss-of-function mutations in moe result in defects in brain ventricle formation, retinal pigmented epithelium and neural retinal development, pericar...

journal_title：BMC developmental biology

authors： Christensen AK,Jensen AM

更新日期：2008-01-11 00:00:00

abstract：BACKGROUND:Our current knowledge on tooth development derives primarily from studies in mice. Very little is known about gene expression and function during human odontogenesis. Sonic Hedgehog (SHH) signaling has been demonstrated to play crucial roles in the development of multiple organs in mice, including the tooth....

journal_title：BMC developmental biology

authors： Hu X,Zhang S,Chen G,Lin C,Huang Z,Chen Y,Zhang Y

更新日期：2013-04-08 00:00:00

abstract：BACKGROUND:Vertebrate limb development involves a reciprocal feedback loop between limb mesenchyme and the overlying apical ectodermal ridge (AER). Several gene pathways participate in this feedback loop, including Fgf signaling. In the forelimb lateral plate mesenchyme, Tbx5 activates Fgf10 expression, which in turn i...

journal_title：BMC developmental biology

authors： Camarata T,Snyder D,Schwend T,Klosowiak J,Holtrup B,Simon HG

更新日期：2010-10-15 00:00:00

abstract：BACKGROUND:The first distinct differentiation event in mammals occurs at the blastocyst stage when totipotent blastomeres differentiate into either pluripotent inner cell mass (ICM) or multipotent trophectoderm (TE). Here we determined, for the first time, global gene expression patterns in the ICM and TE isolated from...

journal_title：BMC developmental biology

authors： Ozawa M,Sakatani M,Yao J,Shanker S,Yu F,Yamashita R,Wakabayashi S,Nakai K,Dobbs KB,Sudano MJ,Farmerie WG,Hansen PJ

更新日期：2012-11-06 00:00:00