Abstract:
:SV40 DNA sequences have been detected in non-Hodgkin's lymphoma patients. A link between SV40 and NHL is biologically plausible since SV40 causes hematological malignancies in laboratory rodents. We investigated 266 Egyptian cases of hematological malignancies (158 NHL, 54 HD, 26 ALL, 13 AML, 8 CLL, 7 CML) and 34 subjects as a control for detection of SV40 DNA using nested PCR. SV40 DNA sequences were found in (53.8%) of NHL, (29.6%) of HD and in (40.7%) of different types of leukemia cases. Frequency of SV40 DNA sequences was higher in NHL patients compared with those with the other tumors and control group (p < 0.05). The highest frequency was in Burkitt's lymphoma followed by diffuse large B-cell lymphoma. The present study suggests that SV40 is significantly associated with non-Hodgkin's lymphoma and most probably acts as a cofactor in the pathogenesis of these tumors. This could lead to new diagnostic, therapeutic, and preventive approaches.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Zekri AR,Mohamed W,Bahnassy A,Refat L,Khaled M,Shalaby S,Hafez Mdoi
10.1080/10428190701534408subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1828-34issue
9eissn
1042-8194issn
1029-2403pii
781796786journal_volume
48pub_type
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