Abstract:
:Our objective was to determine whether the goal of high-dose therapy should be a partial hematologic response or a complete response. We analyzed 282 consecutive stem cell transplant patients. A partial hematologic response was achieved in 108 patients (38%), and 93 (33%) achieved a complete hematologic response. Survival rates of patients with complete, partial, or no response were significantly different (p<0.001), even after eliminating bias from early death. The degree of response was affected by the intensity of chemotherapy conditioning, septal thickness, and cardiac biomarkers. Hematologic response translates to longer survival.
journal_name
Haematologicajournal_title
Haematologicaauthors
Gertz MA,Lacy MQ,Dispenzieri A,Hayman SR,Kumar SK,Leung N,Gastineau DAdoi
10.3324/haematol.11413subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1415-8issue
10eissn
0390-6078issn
1592-8721pii
92/10/1415journal_volume
92pub_type
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