Drug-induced cardiovascular disorders.

Abstract:

:As the variety and range of pharmaceutical agents available to the medical profession continues to expand, one unavoidable effect will be an increase in drug-induced disease, including cardiovascular disorders. However, given the high rates of cardiovascular disease and prevalence of recognised cardiovascular risk factors in the population, it is sometimes impossible to conclusively attribute any individual patients' ill health to one particular drug. As a result, the relationship between drugs and cardiovascular disease is often difficult to quantify. This review discusses specific forms of drug-induced cardiovascular disease such as heart failure, left ventricular systolic dysfunction, hypertension and arrhythmia. Suspected culprit drugs for all disorders are highlighted. Specific attention is given to certain drug groups with a strong association with one or more forms of cardiovascular disease: these include anthracyclines, antipsychotics, NSAIDs and cyclo-oxygenase 2 inhibitors. Additionally, advice is offered on how physicians might distinguish drug-induced cardiovascular disorders from other aetiologies.

journal_name

Drug Saf

journal_title

Drug safety

authors

Murphy CA,Dargie HJ

doi

10.2165/00002018-200730090-00005

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

783-804

issue

9

eissn

0114-5916

issn

1179-1942

pii

3095

journal_volume

30

pub_type

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