Abstract:
:Sirolimus is used as a powerful immunosuppressant drug in patients after organ transplantation. It was shown to block spermatogenesis by interrupting the stem cell factor/c-kit system. Oligozoospermia was shown in single patients. In addition, a decrease of testosterone and an increase of gonadotropin levels were observed. We report on a young patient who showed azoospermia during the treatment with sirolimus after renal transplantation. After changing the immunosuppression to tacrolimus, spermatogenesis of the patient recovered. Five months after cessation of the treatment with sirolimus, a sperm concentration of 8 x 10(6) ml(-1) was found. Depression of spermatogenesis is an important side effect in younger men who aspire paternity, so that waiving of sirolimus is advisable in these patients.
journal_name
Andrologiajournal_title
Andrologiaauthors
Skrzypek J,Krause Wdoi
10.1111/j.1439-0272.2007.00787.xsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
198-9issue
5eissn
0303-4569issn
1439-0272pii
AND787journal_volume
39pub_type
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