Long-term hypothermic lung preservation: does adenosine A1 receptor antagonism have a role in ischemic preconditioning protection?

Abstract:

:Ischemic preconditioning or phosphodiesterase inhibition improves lung protection during prolonged hypothermic storage. In ischemic preconditioning of cat lungs, adenosine A1 receptor antagonism was suggested as a possible mechanism. Some phosphodiesterase inhibitors (such as theophylline) are also adenosine antagonists; we showed theophylline to be particularly effective in protecting lungs. In isolated, perfused and ventilated rat lungs, we examined (1) whether synergy exists between phosphodiesterase inhibition and ischemic preconditioning and (2) whether theophylline acts both to inhibit phosphodiesterase and block adenosine receptors, by comparing its effects with enprofylline (selective phosphodiesterase inhibition) or xanthine amine congener (selective adenosine A1 receptor antagonism). In Study 1, rolipram (added to St Thomas' cardioplegia) or ischemic preconditioning before hypothermic storage (8 h) did not improve lung function during reperfusion (40 min); a combination of these treatments was also ineffective. In Study 2, lungs stored in St Thomas' cardioplegia containing enprofylline or theophylline had improved recovery of function compared to control lungs; however, xanthine amine congener was without effect. Thus, no interaction exists between phosphodiesterase inhibition and ischemic preconditioning. Adenosine A1 receptor antagonism plays no role in protecting rat lungs from the effects of prolonged hypothermic storage by either preconditioning or addition of theophylline to the storage solution.

authors

Featherstone RL,Chambers DJ

doi

10.1016/S1569-9293(03)00274-3

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

182-7

issue

1

eissn

1569-9293

issn

1569-9285

pii

3/1/182

journal_volume

3

pub_type

杂志文章
  • Splenic injury following diaphragmatic plication: an avoidable life-threatening complication.

    abstract::We report an unusual complication of left-sided diaphragmatic plication, namely bleeding from the spleen due to tearing of adhesions between the spleen and the abdominal aspect of the diaphragm. We believe that making a small incision in the diaphragm prior to the plication to identify and divide the adhesions could h...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2009.214288

    authors: Pathak S,Page RD

    更新日期:2009-12-01 00:00:00

  • A remarkable outcome after video-assisted thoracoscopic resection of a giant bulla.

    abstract::A 56-year-old woman visited our hospital for mild exertional dyspnea. Radiological investigations revealed a giant bulla of the left lung that was treated with video-assisted thoracoscopic bullectomy. The result of treatment was a better stamina, and, more strikingly, a major change of voice. ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1016/S1569-9293(03)00169-5

    authors: Schnater JM,Plaisier PW,van den Berg PM,Schütte PR

    更新日期:2003-12-01 00:00:00

  • Solitary pulmonary metastasis of mucoepidermoid carcinoma of the palate 43 years after the initial treatment.

    abstract::This report describes the case of a 71-year-old female presenting with a metastatic mucoepidermoid carcinoma (MEC) in the lung 43 years after the initial treatment for the primary tumor. This case represents a very long period between initial diagnosis and distant metastasis with a pathological examination of both the...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2009.211755

    authors: Okami J,Tomita Y,Higashiyama M,Kodama K

    更新日期:2009-10-01 00:00:00

  • When operable patients become inoperable: conversion of a surgical aortic valve replacement into transcatheter aortic valve implantation.

    abstract::Transcatheter aortic valve implantation (TAVI) is a relatively new treatment option for inoperable patients with severe aortic stenosis (AS). This case describes how a planned conventional surgical aortic valve replacement (AVR) on a 73-year-old woman was successfully converted to a TAVI procedure. On extracorporal ci...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2009.211144

    authors: Olsen LK,Arendrup H,Engstrøm T,Søndergaard L

    更新日期:2009-11-01 00:00:00

  • Extra-anatomic aortic bypass for complex (re-) coarctation and hypoplastic aortic arch in adolescents and adults.

    abstract::Various surgical approaches have been proposed for complex (re-) coarctation and aortic arch hypoplasia (AAH). We report seven patients (mean age 19.6+/-9.5 years) with complex coarctation or re-coarctation and AAH successfully treated by extra-anatomic ascending-to-descending aortic bypass (ADB) via sternotomy betwee...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1016/S1569-9293(02)00122-6

    authors: Berdat PA,Göber V,Carrel T

    更新日期:2003-06-01 00:00:00

  • Facilitating technologies in minimally invasive aortic valve replacement: a propensity score analysis.

    abstract:OBJECTIVES:Minimally invasive aortic valve replacement (MIAVR) can be technically demanding and may lead to prolonged operative time. We evaluated the intraoperative and postoperative patient outcomes following implementation of 2 facilitating technologies (FT) in MIAVR: the Cor-Knot titanium fastener and Custodiol-his...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivy026

    authors: Plestis K,Orlov O,Shah VN,Wong J,Thomas M,Aharon A,Orlov C,Panagopoulos G,Goldman S

    更新日期:2018-08-01 00:00:00

  • Does body mass index impact the early outcome of surgical revascularization? A comparison between off-pump and on-pump coronary artery bypass grafting.

    abstract:OBJECTIVES:To investigate the effects of body mass index (BMI) on early outcomes after revascularization using either on-pump or off-pump surgery. METHODS:Data for 3714 of 4314 patients who underwent surgical revascularization at our institution between 1999 and 2008 were analysed. Patients were divided into two group...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivu246

    authors: Caliskan E,Güsewell S,Seifert B,Theusinger OM,Starck CT,Pavicevic J,Reser D,Holubec T,Plass A,Falk V,Emmert MY

    更新日期:2014-11-01 00:00:00

  • Aortic valve construction using pericardial tissue: short-term single-centre outcomes.

    abstract:OBJECTIVES:Aortic valve construction using pericardial tissue has been known since the late 1960s. The procedure was re-introduced by Ozaki in 2010 and is currently used to treat specific aortic valve diseases. The exact sizing of the neo-cusps and the insertion of the commissures remain the keys to success when perfor...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivy230

    authors: Mourad F,Shehada SE,Lubarski J,Serrano M,Demircioglu E,Wendt D,Jakob H,Benedik J

    更新日期:2019-02-01 00:00:00

  • Rescue mitral valve repair one hour after birth.

    abstract::Congenital mitral regurgitation is rare and usually part of complex cardiac anomalies. When needed, early surgery represents a great challenge. In small babies avoiding valve replacement is desirable, but valve repair may be extremely complex. We describe an isolated congenital mitral regurgitation, successfully treat...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2010.241828

    authors: Deorsola L,Chiappa E,Agnoletti G,Abbruzzese PA

    更新日期:2010-11-01 00:00:00

  • The importance of costoclavicular space on possible compression of the subclavian artery in the thoracic outlet region: a radio-anatomical study.

    abstract:OBJECTIVES:The purposes of this study were to identify possible compression points along the transit route of the subclavian artery and to provide a detailed anatomical analysis of areas that are involved in the surgical management of the thoracic outlet syndrome (TOS). The results of the current study are based on mea...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivy129

    authors: Kaplan T,Comert A,Esmer AF,Ataç GK,Acar HI,Ozkurt B,Tekdemir I,Han S

    更新日期:2018-10-01 00:00:00

  • The use of ultrasound in the management of a life-threatening malignant laryngotracheal obstruction.

    abstract::Ultrasound is becoming a valuable diagnostic tool in the armamentarium of thoracic surgeons. We report its use to follow stent placement in the laryngotracheal position for management of life-threatening neoplastic obstruction. For this purpose, a 15-MHz linear probe was placed in the midline at the level of the crico...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivx298

    authors: Fiorelli A,Messina G,Raucci A,Santini M

    更新日期:2018-02-01 00:00:00

  • A new extracorporeal vacuum-assisted device to optimize cardiopulmonary bypass. Comparison with the conventional system.

    abstract::Miniaturized cardiopulmonary bypass (CPB) systems, though more biocompatible, are limited by not being adaptable to all cardiac surgical operations. We evaluate a versatile CPB system [extracorporeal vacuum-assisted device optimized (EVADO)] based on the elimination of roller pumps, separation of extracavitary suction...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1510/icvts.2010.258921

    authors: Nasso G,Costantini C,Petralia A,Del Prete A,Lopriore V,Fattouch K,Paterno C,Speziale G

    更新日期:2011-04-01 00:00:00

  • What's new in heart failure therapy 2018?

    abstract::Even though significant progress has been made over the past 3 decades, heart failure remains one of the leading causes of mortality and morbidity in developed countries and contributes significantly to the economic burden of modern health care systems. Especially in patients with preserved ejection fraction, valid th...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章,评审

    doi:10.1093/icvts/ivy282

    authors: Westphal JG,Bekfani T,Schulze PC

    更新日期:2018-12-01 00:00:00

  • Untreated tetralogy of Fallot in an adult patient complicated by acute aortic valve endocarditis.

    abstract::Acute endocarditis complicated by aortic valve regurgitation is an uncommon finding in adults with surgical untreated tetralogy of Fallot (TOF). The hemodynamic consequences for both, the right and left ventricles, are significant. However, the right ventricle may be in a disastrous situation, since a compromised righ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1016/j.icvts.2004.01.009

    authors: Knobloch K,Lichtenberg A,Haverich A,Leyh RG

    更新日期:2004-06-01 00:00:00

  • What is the optimal dose of aspirin after discharge following coronary bypass surgery.

    abstract::A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was, what is the optimal dose of aspirin post cardiac surgery that should be given to prevent graft occlusion and prolong survival. Altogether, 114 papers were found from Medline and 59 papers were found fro...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1016/S1569-9293(03)00202-0

    authors: Dunning J,Das S

    更新日期:2003-12-01 00:00:00

  • A novel use of the implantable ventricular assist device for isolated right heart failure.

    abstract::Isolated right heart failure after cardiac surgery is uncommon and the prognosis remains poor. Additionally, managements for these patients are difficult. Profound postcardiotomy right heart failure developed in a 45-year-old woman after aortic root replacement for critical aortic stenosis with small aortic root. Alth...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2008.180620

    authors: Osaki S,Edwards NM,Johnson MR,Kohmoto T

    更新日期:2008-08-01 00:00:00

  • Simplified model for end-stage liver disease score predicts mortality for tricuspid valve surgery.

    abstract:OBJECTIVES:The model for end-stage liver disease score (MELD = 3.8*LN[total bilirubin] + 9.6*LN[creatinine] + 11.2*[PT-INR] + 6.4) predicts mortality for tricuspid valve surgery. However, the MELD is problematic in patients undergoing warfarin therapy, as warfarin affects the international normalized ratio (INR). This ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivt014

    authors: Tsuda K,Koide M,Kunii Y,Watanabe K,Miyairi S,Ohashi Y,Harada T

    更新日期:2013-05-01 00:00:00

  • Late outcomes for the surgical management of absent pulmonary valve syndrome in infants.

    abstract:OBJECTIVES:Absent pulmonary valve syndrome (APVS) is a rare cardiac malformation that is usually associated with aneurysmal dilatation of pulmonary arteries and respiratory distress. The surgical mortality of neonates and infants with APVS has decreased tremendously, from 60% in 1980s to 10-20% recently. This study ret...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivt050

    authors: Hu R,Zhang H,Xu Z,Liu J,Su Z,Ding W

    更新日期:2013-06-01 00:00:00

  • Plasma brain natriuretic peptide as a biomarker for haemodynamic outcome and mortality following pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension.

    abstract:OBJECTIVES:In chronic thromboembolic pulmonary hypertension (CTEPH), right ventricular (RV) dysfunction is associated with increased morbidity and mortality following pulmonary endarterectomy. Plasma brain natriuretic peptide (BNP) levels were previously shown to correlate with RV (dys)function. We hypothesized that BN...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivs415

    authors: Surie S,Reesink HJ,van der Plas MN,Hardziyenka M,Kloek JJ,Zwinderman AH,Bresser P

    更新日期:2012-12-01 00:00:00

  • Giant left coronary ostial aneurysm after modified Bentall procedure in a Marfan patient.

    abstract::We performed surgical repair of a giant left coronary ostial aneurysm after aortic root replacement using composite valve graft (modified Bentall procedure) in a patient with Marfan syndrome. Aneurysmal formation in the left main stem itself is very rare. In order to avoid mobilizing the coronary ostium from severe ad...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2008.183103

    authors: Okamoto K,Casselman FP,De Geest R,Vanermen H

    更新日期:2008-12-01 00:00:00

  • Can the left subclavian artery revascularization during aortic arch surgery be managed using the in situ left internal mammary artery?

    abstract::The management of the left subclavian artery (LSA) revascularization during aortic arch surgery is controversial and often challenging, especially during an emergency life-saving procedure. We report on a case of a 64-year old man, admitted to our institution with a Type A acute aortic dissection who underwent a froze...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivw098

    authors: Magagna P,Cresce GD,Auriemma S,Salvador L

    更新日期:2016-07-01 00:00:00

  • First experience with the ultra compact mobile extracorporeal membrane oxygenation system Cardiohelp in interhospital transport.

    abstract::In patients with severe cardiopulmonary failure extracorporeal assist devices are to support patients during resuscitation, for transportation, until organ recovery, and as bridge to further therapeutic modalities. We report on our first experience with the new Cardiohelp system for interhospital transfer of cardiopul...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2010.264630

    authors: Philipp A,Arlt M,Amann M,Lunz D,Müller T,Hilker M,Graf B,Schmid C

    更新日期:2011-06-01 00:00:00

  • Vacuum assisted closure therapy for the treatment of sternal wound infections in neonates and small infants.

    abstract::Sternal wound infections occur with an incidence between 0.4 and 5% in the adult as well as the pediatric population. However, in contrast to the adults, established treatment options do not exist in the pediatric population. We evaluated our preliminary results with 3 neonates, respectively, small infants (mean age 2...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2005.122424

    authors: Fleck T,Simon P,Burda G,Wolner E,Wollenek G

    更新日期:2006-06-01 00:00:00

  • Leaflet tear in a Trifecta aortic bioprosthesis 34 months after implantation.

    abstract::Bioprosthetic valves are used in aortic valve replacement to avoid lifelong anticoagulation. Bovine pericardial valves have excellent haemodynamics and equivalent freedom from reoperation compared with a porcine bioprosthesis [ 1]. However, early failure (parastent post-cusp tear) can take place due to mechanical stre...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivu384

    authors: Piñón M,Durán D,Pazos P,Pradas G

    更新日期:2015-02-01 00:00:00

  • Cardiopulmonary bypass using nafamostat mesilate for patients with infective endocarditis and recent intracranial hemorrhage.

    abstract::Infective endocarditis is a life threatening disease with high mortality and morbidity, including brain infarction concomitant with intracranial hemorrhage. Generally, patients with a recent intracranial hemorrhage are believed to be a contraindication to undergo cardiac surgery with cardiopulmonary bypass. However, s...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2006.146209

    authors: Ota T,Okada K,Kano H,Okita Y

    更新日期:2007-06-01 00:00:00

  • Extracorporeal life support in the acute management of tumour lysis syndrome.

    abstract::A 16-month old boy presented with a severe tumour lysis syndrome (TLS) complicating induction therapy for acute myeloid leukaemia. This was further complicated by a respiratory syncytial virus infection. The failure of response to escalating treatment necessitated the use of extracorporeal life support (ECLS) during c...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivs233

    authors: Prabhu AD,Mos K,Karl TR,Anderson B

    更新日期:2012-09-01 00:00:00

  • Pulmonary middle lobe fixation using TachoComb in patients undergoing right upper lobectomy with complete oblique fissure.

    abstract::Postoperative lobar torsion is a life-threatening complication of pulmonary resection. To prevent this complication, pulmonary lobe fixation has been proposed. We present here a new technique of middle lobe fixation after right upper lobectomy, using TachoComb, a collagen fleece coated with fibrin glue. This technique...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1016/S1569-9293(03)00232-9

    authors: Higashiyama M,Takami K,Higaki N,Kodama K

    更新日期:2004-03-01 00:00:00

  • Trileaflet pulmonary valve reconstruction for pulmonary regurgitation in childhood.

    abstract::A 6-year-old boy with pulmonary regurgitation after complete repair of congenital heart disease underwent an alternative surgical repair for pulmonary valve replacement. Trileaflet pulmonary valve reconstruction using expanded polytetrafluoroethylene membrane is a clinically feasible technique for pulmonary regurgitat...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivy196

    authors: Ishimaru K,Kanaya T,Sakamoto S,Sawa Y

    更新日期:2018-12-01 00:00:00

  • Effect of a reduced donor heart right ventricular distensibility on post-heart transplant haemodynamics.

    abstract:OBJECTIVES:This study aimed to investigate the characteristics of a reduced right ventricular distensibility after heart transplant. METHODS:This study enrolled 64 adult patients who underwent heart transplant at our institution. The degree of right ventricular distensibility was quantified by calculating the differen...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivaa222

    authors: Nakamura Y,Yoshioka D,Asanoi H,Miyagawa S,Yoshikawa Y,Hata H,Sakaniwa R,Toda K,Sawa Y

    更新日期:2021-01-01 00:00:00

  • Left ventricular performance in aortic valve replacement.

    abstract::We analyzed the mid-term left ventricular (LV) performance after aortic valve replacement (AVR). We measured LV contractility (end-systolic elastance: Ees), afterload (effective arterial elastance: Ea) and efficiency (ventriculoarterial coupling: Ea/Ees; ratio of stroke work and pressure-volume area: SW/PVA) based on ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2009.202309

    authors: Tanoue Y,Maeda T,Oda S,Baba H,Oishi Y,Tokunaga S,Nakashima A,Tominaga R

    更新日期:2009-08-01 00:00:00