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EUS-guided FNA diagnostic yield of malignancy in solid pancreatic masses: a benchmark for quality performance measurement.

Abstract：

BACKGROUND:The diagnostic yield of EUS-guided FNA (EUS-FNA) of solid pancreatic masses is a potential benchmark for EUS-FNA quality, because the majority of EUS-FNA of solid pancreatic masses should be diagnostic for malignancy. OBJECTIVES:To determine the cytologic diagnostic rate of malignancy in EUS-FNA of solid pancreatic masses and to determine if variability exists among endoscopists and centers. DESIGN:Multicenter retrospective study. PATIENTS:EUS centers provided cytology reports for all EUS-FNAs of solid, noncystic, >or=10-mm-diameter, solid pancreatic masses during a 1-year period. MAIN OUTCOME MEASUREMENT:Cytology diagnostic of pancreatic malignancy. RESULTS:A total of 1075 patients underwent EUS-FNA at 21 centers (81% academic) with 41 endoscopists. The median number of EUS-FNA of solid pancreatic masses performed during the year per center was 46 (range, 4-177) and per endoscopist was 19 (range, 1-97). The mean mass dimensions were 32 x 27 mm, with 73% located in the head. The mean number of passes was 3.5. Of the centers, 90% used immediate cytologic evaluation. The overall diagnostic rate of malignancy was 71%, 95% confidence interval 0.69%-0.74%, with 5% suspicious for malignancy, 6% atypical cells, and 18% negative for malignancy. The median diagnostic rate per center was 78% (range, 39%-93%; 1st quartile, 61%) and per endoscopist was 75% (range, 0%-100%; 1st quartile, 52%). LIMITATIONS:Retrospective study, participation bias, and varying chronic pancreatitis prevalence. CONCLUSIONS:(1) EUS-FNA cytology was diagnostic of malignancy in 71% of solid pancreatic masses and (2) endoscopists with a final cytologic diagnosis rate of malignancy for EUS-FNA of solid masses that was less than 52% were in the lowest quartile and should evaluate reasons for their low yield.

journal_name

Gastrointest Endosc

journal_title

Gastrointestinal endoscopy

authors

Savides TJ,Donohue M,Hunt G,Al-Haddad M,Aslanian H,Ben-Menachem T,Chen VK,Coyle W,Deutsch J,DeWitt J,Dhawan M,Eckardt A,Eloubeidi M,Esker A,Gordon SR,Gress F,Ikenberry S,Joyce AM,Klapman J,Lo S,Maluf-Filho F,Nic

doi

10.1016/j.gie.2007.01.017

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

277-82

issue

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(07)00031-4

journal_volume

pub_type

杂志文章,多中心研究

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EUS-guided FNA diagnostic yield of malignancy in solid pancreatic masses: a benchmark for quality performance measurement.