Abstract：
:Adult neurogenesis is a characteristic feature of the olfactory pathways of decapod crustaceans. In crayfish and clawed lobsters, adult-born neurons are the progeny of precursor cells with glial characteristics located in a neurogenic niche on the ventral surface of the brain. The daughters of these precursor cells migrate during S and G(2 )stages of the cell cycle along glial fibers to lateral (cluster 10) and medial (cluster 9) proliferation zones. Here, they divide (M phase) producing offspring that differentiate into olfactory interneurons. The complete lineage of cells producing neurons in these animals, therefore, is arranged along the migratory stream according to cell cycle stage. We have exploited this model to examine the influence of environmental and endogenous factors on adult neurogenesis. We find that increased levels of serotonin upregulate neuronal production, as does maintaining animals in an enriched (versus deprived) environment or augmenting their diet with omega-3 fatty acids; increased levels of nitric oxide, on the other hand, decrease the rate of neurogenesis. The features of the neurogenic niche and migratory streams, and the fact that these continue to function in vitro, provide opportunities unavailable in other organisms to explore the sequence of cellular and molecular events leading to the production of new neurons in adult brains.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Sullivan JM,Sandeman DC,Benton JL,Beltz BSdoi
10.1007/s10735-007-9112-7subject
Has Abstractpub_date
2007-12-01 00:00:00pages
527-42issue
6eissn
1567-2379issn
1567-2387journal_volume
38pub_type
杂志文章abstract：:In in vitro and in vivo systems, understanding localization and the functional role of ATP is essential, but effective methods to monitor ATP in cells and tissues are limited. Although quinacrine dihydrochloride is a well-known fluorescent dye used to detect ATP, it is limited in its use because it shows non-specific ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-012-9474-3
更新日期：2013-04-01 00:00:00
abstract：:The aim of this study was to ascertain whether, like many cell types in cartilaginous tissues if type XI collagen was a pericellular component of annulus fibrosus (AF) cells and chondrocytes. Fine fibrillar networks were visualised which were perlecan, HS (MAb 10E4) and type XI collagen positive. Heparitinase-III pre-...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09823-1
更新日期：2019-06-01 00:00:00
abstract：:Previous studies demonstrate significant roles for passive water channels (aquaporins, AQPs) in maintaining water homeostasis in cell membranes of endometrial cells during decidualisation and embryo implantation. However, there is little information regarding the role of AQPs in the human fallopian tube, specifically ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-012-9471-6
更新日期：2013-04-01 00:00:00
abstract：:Previous findings have shown that P2X-purinoceptor-mediated signaling pathways regulate the release of ACh in the retina. We previously reported the existence of immunoreactivity for P2X1-, P2X2-, P2X4-, and P2X7-purinoceptors in mouse retina and speculated that P2X2 and P2X7-purinoceptors may modulate the activity of...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9107-4
更新日期：2007-08-01 00:00:00
abstract：:p53 plays a pivotal role in the prevention of human tumor formation. p73 and p63 are new members of the p53 tumor suppressor family, which are becoming increasingly recognized as important players in human tumorigenesis. However, the roles of these proteins are not well elucidated in extrahepatic bile duct (EBD) carci...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9084-7
更新日期：2007-06-01 00:00:00
abstract：:Pulp regeneration using human dental pulp stem cells (hDPSCs) maintains tooth vitality compared with conventional root canal therapy. Our previous study demonstrated that preameloblast-conditioned medium (PA-CM) from murine apical bud cells induces the odontogenic differentiation of hDPSCs and promoted dentin formatio...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9513-8
更新日期：2013-12-01 00:00:00
abstract：:Tissue microarrays have become an essential tool in translational pathology. They are used to confirm results from other experimental platforms, such as expression microarrays, as well as a primary tool to explore the expression profile of proteins by immunohistochemical analysis. Tissue microarrays are routinely used...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-006-9049-2
更新日期：2007-05-01 00:00:00
abstract：:This study aimed to explore whether the altered expression of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF) and apoptotic changes in mid zone (MZ) and rupture zone (RZ) of fetal membranes (FM) are regulatory mechanisms associated with labor at term. Fifteen FM specimens were collected ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9553-0
更新日期：2014-06-01 00:00:00
abstract：:Quercetin (3,5,7,3',4'-pentahydroxyflavone) is one of the most abundant natural flavonoids. It is present in various common vegetables and fruits. In this report, we examined the effect of quercetin on melanogenesis using a three-dimensional reconstituted human epidermal culture model, MelanoDerm, which is a new comme...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1023/b:hijo.0000023388.51625.6c
更新日期：2004-02-01 00:00:00
abstract：:During transmyocardial revascularization, cellular destruction of cardiomyocytes occurs as a result of the high-energy laser. However, the features of myocardial cellular destruction are unclear. The present study was undertaken to examine the structural characteristics of cell death in the myocardium following transm...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-005-5343-7
更新日期：2005-05-01 00:00:00
abstract：:Diabetic nephropathy (DN), a serious complication of hyperglycemia, is one of the most common causes of end-stage renal disease (ESRD). Glomerular podocyte injury is a major mechanism that leads to DN. However, the mechanisms underlying podocyte injury are ambiguous. In this study, we sought to investigate the contrib...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09904-6
更新日期：2020-10-01 00:00:00
abstract：:MT1-MMP and TIMP-2 are well known for their roles in remodelling of extracellular matrix components. However, reports are emerging on the involvement of these molecules in cell kinetics. In the rat incisor tooth, a shortening treatment increases the eruption and cell proliferation rates. However, the role of MT1-MMP a...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-010-9295-1
更新日期：2010-12-01 00:00:00
abstract：:Some members of aquaporin family (AQP) plays crucial functions in salivary synthesis and secretion. These proteins expression has already been reported during salivary gland formation, however no previous studies in human developing glands have been performed. We evaluated AQP1, 3 and 5 expression through the stages o...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-017-9731-6
更新日期：2017-12-01 00:00:00
abstract：:Epidermal adult stem cells (EpiASCs) have the potential for unlimited proliferation and differentiation, however, the ability of these stem cells to activate corneal genetic programs in response to corneal stroma stimulation needs to be further validated. Herein, a feasible strategy was developed to reconstruct the da...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09879-4
更新日期：2020-06-01 00:00:00
abstract：:Inpp5f-v3 is a transcriptional variant of Inpp5f (inositol polyphosphate-5-phosphatase F) and locates in distal mouse chromosome 7. It is a paternally expressed imprinted gene in mouse. In this study, we examined the spatiotemporal patterns of Inpp5f-v3 gene during the mouse development. The northern blotting analysis...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-011-9321-y
更新日期：2011-04-01 00:00:00
abstract：:Odontogenic keratocysts (OKCs) are jaw cystic lesions which are characterized by local invasion and high recurrence rate. The majority of OKCs are exposed to microorganisms and occur along with focal inflammatory infiltrates. Cyst fluids are biological fluids that contain a large content of cytokines and immune globul...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09829-9
更新日期：2019-08-01 00:00:00
abstract：:Stromal cells in the peripheral zone (PZ) of the prostate from older males (PZ-old) could significantly promote Prostate cancer (PCa) growth compared with stromal cells from young males (PZ-young). But the mechanism is still unknown. In the co-culture system with PZ-old cells, Pc3/Du145 cells showed advanced prolifera...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-016-9679-y
更新日期：2016-06-01 00:00:00
abstract：:Aquaporins (AQPs), the rapid transition pores for water molecules, play an important role in maintenance of intracellular water balance. Studies showed that AQPs were also involved in occurrence, development, invasion and metastasis of tumors. In this study, we aimed to explore the distribution and expression differen...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-016-9657-4
更新日期：2016-04-01 00:00:00
abstract：:Spatio-temporal immunolocalizations of cytokeratin 8 (CK8), vimentin, syndecan-1 and Ki-67 were analyzed in ten human incisors and canine tooth germs between the 7th and 20th developmental weeks. CK8 expression was mild to moderate in the epithelial tooth parts, while it shifted from absent or mild in its mesenchymal ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-014-9592-1
更新日期：2014-12-01 00:00:00
abstract：:Recent studies have shown that chronic endothelial dysfunction can impair multiple aspects of renal physiology and, in turn, contribute to renal fibrosis. Sphingosine 1-phosphate (S1P) has been highlighted as an endothelial barrier-stabilizing mediator. The aim of our study was to investigate the effect of FTY720, an ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9521-8
更新日期：2013-12-01 00:00:00
abstract：:In order to study the presence of sulphated glycoconjugates in the first mineralised layer juxtaposed to the root dentine (the hyaline layer), we have examined the early stages of molar root development by ultrastructural cytochemistry using Cuprolinic Blue combined with enzymatic pretreatment. Upper molars from 10 to...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1023/b:hijo.0000021089.75408.7c
更新日期：2004-01-01 00:00:00
abstract：:Cyclin G1 plays an essential role in the development of human carcinoma. Here, we characterized the clinical significance of Cyclin G1 and investigated its role in cellular proliferation and apoptosis of epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of Cyclin G1 in nine fresh EOC ti...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-015-9622-7
更新日期：2015-06-01 00:00:00
abstract：:Alveolar macrophages (AMs) play a vital role in lung immunity. The recent studies demonstrated that potassium channels were associated with macrophage functions, such as activation, migration and cytokines secretion. However, less is known regarding the expression and function of ERG channels in AMs. Our study showed ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-012-9458-3
更新日期：2013-02-01 00:00:00
abstract：:Hyperglycemia is associated with impairment of heart function. The current study aimed to investigate the ameliorative effect of polydatin-loaded chitosan nanoparticles (PD-CSNPs), polydatin (PD) and metformin (MET) on diabetic cardiomyopathy in rats. Rats divided into six groups; normal-control, diabetic-control, dia...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09930-4
更新日期：2021-01-03 00:00:00
abstract：:Satellite glial cells (SGCs), a peripheral neuroglial cell, surround neurons and form a complete envelope around individual sensory neurons in the trigeminal ganglia (TG), which may be involved in modulating neurons in inflammation. The purpose of this study was to determine the effect of dental injury and inflammatio...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-018-9765-4
更新日期：2018-06-01 00:00:00
abstract：:Sphingosine-1-phosphate receptor 1 (S1P(1)), a receptor for sphingosine-1-phosphate, has been shown to play an important role in the migration, proliferation, and survival of several types of cell including endothelial cells. Given that S1P(1) signaling could serve as a therapeutic target, we evaluate the expression o...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-008-9193-y
更新日期：2008-10-01 00:00:00
abstract：:The distribution of molecular components of interendothelial tight junctions (TJs) was studied in rat blood-brain barrier (BBB) microvessels, using immunogold cytochemistry applied to electron microscopy. Samples of rat brains, both normal (unaffected) and osmotically-affected (1, 5, and 30 min after intracarotid infu...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/10.1007/s10735-004-1318-3
更新日期：2004-06-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-015-9609-4
更新日期：2015-04-01 00:00:00
abstract：:Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized tha...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9496-5
更新日期：2013-08-01 00:00:00
abstract：:The aim of the present study was to investigate the association between KDM3A expression and the clinicopathological parameters of patients with epithelial ovarian cancer (EOC). KDM3A expression was analyzed using immunohistochemistry in EOC tissue microarray containing 90 paired cases of EOC and matched normal contro...
journal_title：Journal of molecular histology
pub_type： 撤回出版物,收录出版
doi：10.1007/s10735-015-9642-3
更新日期：2016-04-01 00:00:00
