Interferon-gamma is produced by another player of innate immune responses: the interferon-producing killer dendritic cell (IKDC).

Abstract:

:Interferon-gamma is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-gamma after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.

journal_name

Biochimie

journal_title

Biochimie

authors

Bonmort M,Ullrich E,Mignot G,Jacobs B,Chaput N,Zitvogel L

doi

10.1016/j.biochi.2007.04.014

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

872-7

issue

6-7

eissn

0300-9084

issn

1638-6183

pii

S0300-9084(07)00109-5

journal_volume

89

pub_type

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