Abstract:
:Interferon-gamma is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-gamma after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.
journal_name
Biochimiejournal_title
Biochimieauthors
Bonmort M,Ullrich E,Mignot G,Jacobs B,Chaput N,Zitvogel Ldoi
10.1016/j.biochi.2007.04.014subject
Has Abstractpub_date
2007-06-01 00:00:00pages
872-7issue
6-7eissn
0300-9084issn
1638-6183pii
S0300-9084(07)00109-5journal_volume
89pub_type
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