Biochemical pathways analysis of microarray results: regulation of myogenesis in pigs.

abstract：BACKGROUND:Pbx genes encode TALE class homeodomain transcription factors that pattern the developing neural tube, pancreas, and blood. Within the hindbrain, Pbx cooperates with Hox proteins to regulate rhombomere segment identity. Pbx cooperates with Eng to regulate midbrain-hindbrain boundary maintenance, and with Myo...

journal_title：BMC developmental biology

authors： French CR,Erickson T,Callander D,Berry KM,Koss R,Hagey DW,Stout J,Wuennenberg-Stapleton K,Ngai J,Moens CB,Waskiewicz AJ

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:While the body axis is largely patterned along the anterior-posterior (A-P) axis during gastrulation, the central nervous system (CNS) shows dynamic changes in the expression pattern of Hox genes during neurulation, suggesting that the CNS refines the A-P pattern continuously after neural tube formation. Thi...

journal_title：BMC developmental biology

authors： Amirthalingam GS,Howard S,Alvarez S,de Lera AR,Itasaki N

更新日期：2009-02-25 00:00:00

abstract：BACKGROUND:Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in the coding region of PARM1 has been associated with competence of bovine embryos to develop to the bl...

journal_title：BMC developmental biology

authors： Zolini AM,Negrón-Pérez VM,Hansen PJ

更新日期：2019-07-05 00:00:00

abstract：BACKGROUND:The central nervous tissue contains diverse subtypes of neurons with characteristic morphological and physiological features and different neurotransmitter phenotypes. The generation of neurons with defined neurotransmitter phenotypes seems to be governed by factors differently expressed along the anterior-p...

journal_title：BMC developmental biology

authors： Varga BV,Hádinger N,Gócza E,Dulberg V,Demeter K,Madarász E,Herberth B

更新日期：2008-09-22 00:00:00

abstract：BACKGROUND:Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) is well established on flat, adherent cells. However, blastomeres of mammalian embryos are non-adherent, round and large. Scanning whole mount mammalian embryos with 3D-SIM is prone to failure due to the mov...

journal_title：BMC developmental biology

authors： Popken J,Dahlhoff M,Guengoer T,Wolf E,Zakhartchenko V

更新日期：2015-11-26 00:00:00

abstract：BACKGROUND:Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or function within the optic nerve. As a first step in understanding the role of HDACs in optic nerve, this s...

journal_title：BMC developmental biology

authors： Tiwari S,Dharmarajan S,Shivanna M,Otteson DC,Belecky-Adams TL

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:Germline stem cells (GSCs) are present in the gonads of Drosophila females and males, and their proper maintenance, as well as their correct differentiation, is essential for fertility and fecundity. The molecular characterization of factors involved in maintenance and differentiation is a major goal both in...

journal_title：BMC developmental biology

authors： Cash AC,Andrews J

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Glycosphingolipids (GSL) are integral components of mammalian cell membranes that are involved in cell adhesion and cell signaling processes. GSL are subdivided into structural series, like ganglio-, lacto/neolacto-, globo- and isoglo-series, which are defined by distinct trisaccharide cores. The beta1,3 N-a...

journal_title：BMC developmental biology

authors： Biellmann F,Hülsmeier AJ,Zhou D,Cinelli P,Hennet T

更新日期：2008-11-12 00:00:00

abstract：BACKGROUND:The FERM domain containing protein Mosaic Eyes (Moe) interacts with Crumbs proteins, which are important regulators of apical identity and size. In zebrafish, loss-of-function mutations in moe result in defects in brain ventricle formation, retinal pigmented epithelium and neural retinal development, pericar...

journal_title：BMC developmental biology

authors： Christensen AK,Jensen AM

更新日期：2008-01-11 00:00:00

abstract：BACKGROUND:Despite the detailed knowledge obtained over the last decade on the molecular regulation of gastrulation in amniotes, the process of amnion development has been poorly described and illustrated in mice, and conflicting descriptions exist. Understanding the morphogenesis and development not only of the early ...

journal_title：BMC developmental biology

authors： Pereira PN,Dobreva MP,Graham L,Huylebroeck D,Lawson KA,Zwijsen AN

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Mitogen-activated protein kinase (MAPK) cascades (p38, JNK, ERK pathways) are involved in cell fate acquisition during development. These kinase modules are associated with scaffold proteins that control their activity. In Drosophila, dMP1, that encodes an ERK scaffold protein, regulates ERK signaling during...

journal_title：BMC developmental biology

authors： Mouchel-Vielh E,Rougeot J,Decoville M,Peronnet F

更新日期：2011-03-14 00:00:00

abstract：BACKGROUND:The DNA damage-mediated cell cycle checkpoint is an essential mechanism in the DNA damage response (DDR). During embryonic development, the characteristics of cell cycle and DNA damage checkpoint evolve from an extremely short G1 cell phase and lacking G1 checkpoint to lengthening G1 phase and the establishm...

journal_title：BMC developmental biology

authors： Wang XQ,Chan KK,Ming X,Lui VC,Poon RY,Lo CM,Norbury C,Poon RT

更新日期：2014-05-19 00:00:00

abstract：BACKGROUND:After amputation of the Xenopus tadpole tail, a functionally competent new tail is regenerated. It contains spinal cord, notochord and muscle, each of which has previously been shown to derive from the corresponding tissue in the stump. The regeneration of the neural crest derivatives has not previously been...

journal_title：BMC developmental biology

authors： Lin G,Chen Y,Slack JM

更新日期：2007-05-24 00:00:00

abstract：BACKGROUND:Monocyte chemoattractant protein-1(MCP-1) is a chemokine secreted by Leydig cells and peritubular myoid cells in the rat testis. Its role in regulating the development of Leydig cells via autocrine and paracrine is still unclear. The objective of the current study was to investigate the effects of MCP-1 on L...

journal_title：BMC developmental biology

authors： Zhan X,Zhang J,Li S,Zhang X,Li L,Song T,Liu Q,Lu J,Xu Y,Ge RS

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1. Recently, genetic defects of this pathway have been described, that lead to Cr deficiency, ...

journal_title：BMC developmental biology

authors： Braissant O,Henry H,Villard AM,Speer O,Wallimann T,Bachmann C

更新日期：2005-05-26 00:00:00

abstract：BACKGROUND:The Drosophila larval head is evolutionarily derived at the genetic and morphological level. In the beetle Tribolium castaneum, development of the larval head more closely resembles the ancestral arthropod condition. Unlike in Drosophila, a knirps homologue (Tc-kni) is required for development of the antenna...

journal_title：BMC developmental biology

authors： Peel AD,Schanda J,Grossmann D,Ruge F,Oberhofer G,Gilles AF,Schinko JB,Klingler M,Bucher G

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:Fertilization in Caenorhabditis elegans requires functional SPE-9 protein in sperm. SPE-9 is a transmembrane protein with a predicted extracellular domain that contains ten epidermal growth factor (EGF)-like motifs. The presence of these EGF-like motifs suggests that SPE-9 is likely to function in gamete adh...

journal_title：BMC developmental biology

authors： Zannoni S,L'Hernault SW,Singson AW

更新日期：2003-12-03 00:00:00

abstract：BACKGROUND:The persistence in adult teleost fish of retinal stem cells that exhibit all of the features of true 'adult stem cells'--self-renewal, multipotency, and the capacity to respond to injury by mitotic activation with the ability to regenerate differentiated tissues--has been known for several decades. However, ...

journal_title：BMC developmental biology

authors： Raymond PA,Barthel LK,Bernardos RL,Perkowski JJ

更新日期：2006-07-26 00:00:00

abstract：BACKGROUND:Real-time quantitative PCR is a sensitive and very efficient technique to examine gene transcription patterns in preimplantation embryos, in order to gain information about embryo development and to optimize assisted reproductive technologies. Critical to the successful application of real-time PCR is carefu...

journal_title：BMC developmental biology

authors： Goossens K,Van Poucke M,Van Soom A,Vandesompele J,Van Zeveren A,Peelman LJ

更新日期：2005-12-03 00:00:00

abstract：BACKGROUND:When resources are scant, C. elegans larvae arrest as long-lived dauers under the control of insulin/IGF- and TGFbeta-related signaling pathways. However, critical questions remain regarding the regulation of this developmental event. How do three dozen insulin-like proteins regulate one tyrosine kinase rece...

journal_title：BMC developmental biology

authors： Liu T,Zimmerman KK,Patterson GI

更新日期：2004-09-20 00:00:00

abstract：BACKGROUND:Bats comprise the second largest order of mammals. However, there are far fewer morphological studies of post-implantation embryonic development than early embryonic development in bats. RESULTS:We studied three species of bats (Miniopterus schreibersii fuliginosus, Hipposideros armiger and H. pratti), repr...

journal_title：BMC developmental biology

authors： Wang Z,Han N,Racey PA,Ru B,He G

更新日期：2010-01-21 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) is presumed to be a regulator of metamorphosis in many invertebrate species, and although NO pathways have been comparatively well-investigated in gastropods, annelids and crustaceans, there has been very limited research on the effects of NO on metamorphosis in bivalve shellfish. RESULTS:...

journal_title：BMC developmental biology

authors： Vogeler S,Carboni S,Li X,Nevejan N,Monaghan SJ,Ireland JH,Joyce A

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:In chondrichthyans, basal osteichthyans and tetrapods, vertebral bodies have cartilaginous anlagen that subsequently mineralize (chondrichthyans) or ossify (osteichthyans). Chondrocytes that form the vertebral centra derive from somites. In teleost fish, vertebral centrum formation starts in the absence of c...

journal_title：BMC developmental biology

authors： Bensimon-Brito A,Cardeira J,Cancela ML,Huysseune A,Witten PE

更新日期：2012-10-09 00:00:00

abstract：:Notch signalling acts in virtually every tissue during the lifetime of metazoans. Recent studies have pointed to multiple roles for Notch in stem cells during quiescence, proliferation, temporal specification, and maintenance of the niche architecture. Skeletal muscle has served as an excellent paradigm to examine the...

journal_title：BMC developmental biology

authors： Mourikis P,Tajbakhsh S

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:The developing eye receives blood supply from two vascular systems, the intraocular hyaloid system and the superficial choroidal vessels. In zebrafish, a highly stereotypic and simple set of vessels develops on the surface of the eye prior to development of choroidal vessels. The origins and formation of thi...

journal_title：BMC developmental biology

authors： Kaufman R,Weiss O,Sebbagh M,Ravid R,Gibbs-Bar L,Yaniv K,Inbal A

更新日期：2015-03-27 00:00:00

abstract：BACKGROUND:Dimethyl sulfoxide (DMSO) is used extensively as a permeable cryoprotectant and is a common solvent utilized for several water-insoluble substances. DMSO has various biological and pharmacological activities; however, the effect of DMSO on mouse oocyte meiotic maturation remains unknown. RESULTS:In DMSO-tre...

journal_title：BMC developmental biology

authors： Zhou D,Shen X,Gu Y,Zhang N,Li T,Wu X,Lei L

更新日期：2014-06-21 00:00:00

abstract：BACKGROUND:MiR-9 is a small non-coding RNA that is highly conserved between species and primarily expressed in the central nervous system (CNS). It is known to influence proliferation and neuronal differentiation in the brain and spinal cord of different vertebrates. Different studies have pointed to regional and speci...

journal_title：BMC developmental biology

authors： Alwin Prem Anand A,Huber C,Asnet Mary J,Gallus N,Leucht C,Klafke R,Hirt B,Wizenmann A

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:Somitogenesis is the earliest sign of segmentation in the developing vertebrate embryo. This process starts very early, soon after gastrulation has initiated and proceeds in an anterior-to-posterior direction during body axis elongation. It is widely accepted that somitogenesis is controlled by a molecular o...

journal_title：BMC developmental biology

authors： Tenin G,Wright D,Ferjentsik Z,Bone R,McGrew MJ,Maroto M

更新日期：2010-02-25 00:00:00

abstract：BACKGROUND:Neuroblastoma is a childhood cancer derived from immature cells of the sympathetic nervous system. The disease is clinically heterogeneous, ranging from neuronal differentiated benign ganglioneuromas to aggressive metastatic tumours with poor prognosis. Amplification of the MYCN oncogene is a well establishe...

journal_title：BMC developmental biology

authors： Henriksen JR,Haug BH,Buechner J,Tømte E,Løkke C,Flaegstad T,Einvik C

更新日期：2011-01-03 00:00:00

abstract：BACKGROUND:Formation of branching tubes is a fundamental step in the development of glandular organs. To identify extracellular cues that orchestrate epithelial tubulogenesis, we employed an in vitro assay in which EpH4-J3B1A mammary epithelial cells form spheroidal cysts when grown in collagen gels under serum-free co...

journal_title：BMC developmental biology

authors： Montesano R,Carrozzino F,Soulié P

更新日期：2007-02-08 00:00:00