Quantifying the effects of voluntary contraction and inter-stimulus interval on the human soleus H-reflex.

Abstract:

:The human soleus H-reflex is commonly tested as an indicator of the reflex excitability of the calf muscles with infrequent stimuli to a subject seated and at rest. However, the reflex varies widely with the level of voluntary contraction and with the time history of stimulation. We studied two aspects of this variation. Antagonist (tibialis anterior) activation decreases the response, while increasing agonist (soleus) activation increases the H-reflex to a peak after which it declines. In subjects with large H-reflexes at rest, the reflex peaked at low levels of contraction. In contrast, in subjects with small H-reflexes at rest, the reflex peaked at higher levels of contraction for reasons that were elucidated using a realistic computer model. A parabolic curve fitted the maximum amplitude of the H-reflex in the model and over the entire range of contractile levels studied. The second aspect studied was post-activation depression or homosynaptic depression (HD), which has been described previously as a reduction of a second H-reflex elicited shortly after an initial reflex. We confirmed the presence of HD in resting, seated subjects for intervals up to 4 s. However, by voluntarily activating the soleus muscle, HD was drastically reduced when seated and abolished when standing. This suggests that HD may be absent in normal, functional movements and perhaps in clinical conditions that alter H-reflexes. Meaningful, quantitative measurements of reflex excitability can only be made under voluntary activity that mimics the condition of interest.

journal_name

Exp Brain Res

authors

Stein RB,Estabrooks KL,McGie S,Roth MJ,Jones KE

doi

10.1007/s00221-007-0989-x

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

309-19

issue

3

eissn

0014-4819

issn

1432-1106

journal_volume

182

pub_type

杂志文章
  • Spatio-temporal recoding of rapid eye movement signals in the monkey paramedian pontine reticular formation (PPRF).

    abstract::The integrity of the paramedian pontine reticular formation (PPRF) is necessary for the generation of rapid eye movements. The main saccade-related population is of the burst type with latencies between 0 and 40 ms preceding a saccade, and they can be divided into medium- and long-lead burst neurons. Burst neurons hav...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00237155

    authors: Hepp K,Henn V

    更新日期:1983-01-01 00:00:00

  • Visuomotor restriction of one eye in kittens reared with alternate monocular deprivation.

    abstract::It is known that kittens reared in ways that restrict movement while visual stimulation is received exhibit deficits in visually guided behavior. Presumably, the behavioral dysfunction is due to a lack of sensorimotor coordination during visual exposure. The current investigation was undertaken to study this effect bo...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00238794

    authors: Freeman RD

    更新日期:1978-09-15 00:00:00

  • Comparing kinematic changes between a finger-tapping task and unconstrained finger flexion-extension task in patients with Parkinson's disease.

    abstract::Repetitive finger tapping is a well-established clinical test for the evaluation of parkinsonian bradykinesia, but few studies have investigated other finger movement modalities. We compared the kinematic changes (movement rate and amplitude) and response to levodopa during a conventional index finger-thumb-tapping ta...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-013-3491-7

    authors: Teo WP,Rodrigues JP,Mastaglia FL,Thickbroom GW

    更新日期:2013-06-01 00:00:00

  • Vertical eye movement-related type II neurons with downward on-directions in the vestibular nucleus in alert cats.

    abstract::The vestibular nuclei and the interstitial nucleus of Cajal (INC) have been regarded as key elements of the velocity-to-position integrator for vertical eye movements. This paper reports a class of type II vestibular neurons that receives input from the INC and carries vertical eye movement signals that appear to repr...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-003-1750-8

    authors: Niwa M,Chimoto S,Iwamoto Y,Yoshida K

    更新日期:2004-04-01 00:00:00

  • The integrative role of the intralaminar system of the thalamus in visual orientation and perception in the cat.

    abstract::Electrical stimulation with repetitive pulses (6/sec) was applied to the internal medullary lamina and produced tonic contraversive turning movements of eyes and head which were associated with recruiting responses in the visual cortex. Optical gratings of a spatial frequency of 0.5 c/deg which alternated with diffuse...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00234015

    authors: Hunsperger RW,Roman D

    更新日期:1976-06-18 00:00:00

  • Altered burst responses in hippocampal CA3 neurons injected with EGTA.

    abstract::Intracellular injection of EGTA abolished the hyperpolarization seen after spontaneous and evoked bursts of action potentials in hippocampal CA3 neurons. Simultaneously recorded, orthodromically elicited IPSPs were relatively unaffected by this treatment. It is concluded that CA3 neurons generate at least two types of...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00237513

    authors: Hablitz JJ

    更新日期:1981-01-01 00:00:00

  • Coordination of muscle torques stabilizes upright standing posture: an UCM analysis.

    abstract::The control of upright stance is commonly explained on the basis of the single inverted pendulum model (ankle strategy) or the double inverted pendulum model (combination of ankle and hip strategy). Kinematic analysis using the uncontrolled manifold (UCM) approach suggests, however, that stability in upright standing ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-016-4576-x

    authors: Park E,Reimann H,Schöner G

    更新日期:2016-06-01 00:00:00

  • Catching a gently thrown ball.

    abstract::Several studies have shown that people can catch a ball even if it is visible only during part of its flight. Here, we examine how well they can do so. We measured the movements of a ball and of the hands of both the thrower and the catcher during one-handed underarm throwing and catching. The catcher's sight was occl...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-010-2421-1

    authors: López-Moliner J,Brenner E,Louw S,Smeets JB

    更新日期:2010-10-01 00:00:00

  • Learning of sequential movements by neural network model with dopamine-like reinforcement signal.

    abstract::Dopamine neurons appear to code an error in the prediction of reward. They are activated by unpredicted rewards, are not influenced by predicted rewards, and are depressed when a predicted reward is omitted. After conditioning, they respond to reward-predicting stimuli in a similar manner. With these characteristics, ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050467

    authors: Suri RE,Schultz W

    更新日期:1998-08-01 00:00:00

  • Compensation of postural effects of hemilabyrinthectomy in the cat. A sensory substitution process?

    abstract::A photographic technique was used to study the evolution of lateral head-tilt following hemilabyrinthectomy in adult cats. Animals were maintained post-operatively in normally lit conditions (LM cats), in total darkness (DM cats), or in stroboscopic light. In LM casts, the head tilt peaked at 45 degrees (with the lesi...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00235707

    authors: Putkonen PT,Courjon JH,Jeannerod M

    更新日期:1977-06-27 00:00:00

  • Non monotonic morphometric changes produced at mouse neuromuscular junctions following in vivo stimulation at various frequencies.

    abstract::Morphometric changes have been studied at the mouse neuromuscular junction (NMJ) as a function of the frequency of stimulation. In vivo stimulation was made at either 10, 25, 50 or 100 Hz. No significant change in the area of NMJ profiles is observed after stimulation. This indicates that stimulation does not change t...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00237590

    authors: Tremblay JP,Belhumeur C,Sasseville R,Grégoire L

    更新日期:1986-01-01 00:00:00

  • Early enhancement but no late changes of motor responses induced by intracortical microstimulation in the ketamine-anesthetized rat.

    abstract::The objectives of this study were to determine whether changes in electromyographic (EMG) responses observed during prolonged intracortical microstimulation (ICMS) were due to local plasticity of the motor system or to global changes in the preparation. Local effects would be expressed as changes only along the activa...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00242909

    authors: Gu X,Fortier PA

    更新日期:1996-02-01 00:00:00

  • Enhanced sensitivity to echo cues in blind subjects.

    abstract::Many studies have reported that blind people compensate for their visual deficit by sharpening auditory processes. Here we compare the sensitivity to echo cues between blind and sighted subjects. In the first experiment, the blind subjects were more accurate than the sighted subjects in localizing an object on the bas...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00221-005-2329-3

    authors: Dufour A,Després O,Candas V

    更新日期:2005-09-01 00:00:00

  • Cognitive-perceptual load modulates hand selection in left-handers to a greater extent than in right-handers.

    abstract::Previous studies have proposed that selecting which hand to use for a reaching task appears to be modulated by a factor described as "task difficulty," defined by either the requirement for spatial precision or movement sequences. However, we previously reported that analysis of the movement costs associated with even...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-018-5423-z

    authors: Liang J,Wilkinson KM,Sainburg RL

    更新日期:2019-02-01 00:00:00

  • Effects of LSD on the response of single units in cat visual cortex.

    abstract::The effects of intravenous doses (200 mug) of LSD on the activity of single neurones in the primary visual cortex have been studied in cats anaesthetized with urethane. Cells were stimulated with a bright bar of light moved over the receptive field, and orientation tuning was assessed quantitatively before and after a...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00234826

    authors: Rose D,Horn G

    更新日期:1977-01-18 00:00:00

  • A role for terrain slope in orienting hippocampal place fields.

    abstract::The three-dimensional topography of the environment is a potentially important source of orienting information for animals, but little is known about how such features affect either navigational behaviour or the neural representation of place. One component of the neural place representation comprises the hippocampal ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-005-0138-3

    authors: Jeffery KJ,Anand RL,Anderson MI

    更新日期:2006-02-01 00:00:00

  • Neural correlates of tactile perception during pre-, peri-, and post-movement.

    abstract::Tactile information is differentially processed over the various phases of goal-directed movements. Here, event-related potentials (ERPs) were used to investigate the neural correlates of tactile and visual information processing during movement. Participants performed goal-directed reaches for an object placed centra...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-016-4589-5

    authors: Juravle G,Heed T,Spence C,Röder B

    更新日期:2016-05-01 00:00:00

  • Association of spinal lamina I projections with brainstem catecholamine neurons in the monkey.

    abstract::In addition to giving primary projections to the parabrachial and periaqueductal gray regions, ascending lamina I projections course through and terminate in brainstem regions known to contain catecholaminergic cells. For this reason, double-labeling experiments were designed for analysis with light and electron micro...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00228547

    authors: Westlund KN,Craig AD

    更新日期:1996-07-01 00:00:00

  • Movement strategies in vertical aiming of older adults.

    abstract::The current study examined the movement kinematics of older adults when aiming to vertically oriented targets. Late middle-age and early old-age participants completed 20 trials to a small target located downward or upward by 0.16 m from a home position at shoulder height. Aiming direction had a significant effect, re...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-011-2947-x

    authors: Bennett SJ,Elliott D,Rodacki A

    更新日期:2012-02-01 00:00:00

  • Supervised learning of postural tasks in patients with poststroke hemiparesis, Parkinson's disease or cerebellar ataxia.

    abstract::Supervised learning of different postural tasks in patients with lesions of the motor cortex or pyramidal system (poststroke hemiparesis: 20 patients), nigro-striatal system (Parkinson's disease: 33 patients) and cerebellum (spinocerebellar ataxia: 37 patients) was studied. A control group consisted of 13 healthy subj...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-005-0096-9

    authors: Ioffe ME,Ustinova KI,Chernikova LA,Kulikov MA

    更新日期:2006-01-01 00:00:00

  • Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction of differentiated neuroblastoma cells.

    abstract::Activation of glial cells has been proposed to contribute to neuronal dysfunction and neuronal cell death in Alzheimer's disease. In this study, we attempt to determine some of the effects of secreted factors from activated murine N-11 microglia on viability and morphology of neurons using the differentiated neuroblas...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-003-1389-5

    authors: Münch G,Gasic-Milenkovic J,Dukic-Stefanovic S,Kuhla B,Heinrich K,Riederer P,Huttunen HJ,Founds H,Sajithlal G

    更新日期:2003-05-01 00:00:00

  • Nociceptive neurones in rat superior colliculus. II. Effects of lesions to the contralateral descending output pathway on nocifensive behaviours.

    abstract::A wealth of evidence implicates the crossed descending projection from the superior colliculus (SC) in orientation and approach behaviours directed towards novel, non-noxious stimuli. In our preceding paper, we identified a population of nociceptive neurones in the rat SC that have axons that project to the contralate...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00231781

    authors: Redgrave P,Simkins M,McHaffie JG,Stein BE

    更新日期:1996-05-01 00:00:00

  • Motor evoked potential depression following repetitive central motor initiation.

    abstract::Prior reports have described a transient and focal decline in transcranial magnetic stimulation (TMS)-induced motor evoked potential (MEP) amplitude following fatiguing motor tasks. However, the neurophysiological causes of this change in MEP amplitude are unknown. The aim of this study was to determine whether post-t...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-011-2962-y

    authors: Kluger BM,Palmer C,Shattuck JT,Triggs WJ

    更新日期:2012-02-01 00:00:00

  • Context-dependent force coding in motor and premotor cortical areas.

    abstract::In three monkeys trained to finely grade grip force in a visuomotor step-tracking task, the effect of the context on neuronal force correlates was quantitatively assessed. Three trial types, which differed in force range, number, and direction of the force steps, were presented pseudo-randomly and cued with the color ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050827

    authors: Hepp-Reymond M,Kirkpatrick-Tanner M,Gabernet L,Qi HX,Weber B

    更新日期:1999-09-01 00:00:00

  • Response properties of pigeon otolith afferents to linear acceleration.

    abstract::In the present study, the sensitivity to sinusoidal linear accelerations in the plane of the utricular macula was tested in afferents. The head orientation relative to the translation axis was varied in order to determine the head position that elicited the maximal and minimal responses for each afferent. The response...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050219

    authors: Si X,Angelaki DE,Dickman JD

    更新日期:1997-11-01 00:00:00

  • Local cerebral blood flow in gently restrained rats: effects of propranolol and diazepam.

    abstract::The cerebrovascular consequences of the gentle restraint commonly used for the measurement of local cerebral blood flow (LCBF) in conscious rats has been tested by using two drugs, propranolol and diazepam. Propranolol induced small LCBF decreases in 7 structures suggesting that the cerebral circulation was partially ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00235660

    authors: Lasbennes F,Seylaz J

    更新日期:1986-01-01 00:00:00

  • Bilateral projections from the parabigeminal nucleus to the superior colliculus in monkey.

    abstract::We examined the distribution of labeled neurons in the parabigeminal nucleus of the monkey following injections of retrograde fluorescent tracers into the superior colliculus. The extent of the visual field representation included in the injection site was assessed from the location of labeled cells in striate cortex....

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00230521

    authors: Baizer JS,Whitney JF,Bender DB

    更新日期:1991-01-01 00:00:00

  • Opposite effects of weak transcranial direct current stimulation on different phases of short interval intracortical inhibition (SICI).

    abstract::Short interval intracortical inhibition (SICI) is a common paired-pulse TMS technique that is used to measure GABAa-ergic inhibition in the cerebral motor cortex. However, inhibition evaluated with an interstimulus interval (ISI) between the TMS pulses of 2.5 ms has quite different properties from that seen at 1 ms. I...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-012-3369-0

    authors: Cengiz B,Murase N,Rothwell JC

    更新日期:2013-03-01 00:00:00

  • The primary visual cortex in the mouse: receptive field properties and functional organization.

    abstract::Receptive field (RF) characteristics of cells in primary visual cortex of the mouse (C57B16 strain) were studied by single unit recording. We have studied the functional organization of area 17 along both the radial and tangential dimensions of the cortex. Eighty seven percent of the visual neurons could be classified...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00247312

    authors: Métin C,Godement P,Imbert M

    更新日期:1988-01-01 00:00:00

  • Decreased anxiety levels related to aging.

    abstract::The present experiment investigated the effects of aging on emotional behavior, without concomitant influences from any previous behavioral manipulation apart from weighing the rats. Anxiety-related behaviors were measured in the elevated plus-maze (EPM). Performance in the open field (OF) was also assessed to control...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-005-2240-y

    authors: Torras-Garcia M,Costa-Miserachs D,Coll-Andreu M,Portell-Cortés I

    更新日期:2005-07-01 00:00:00