Abstract：
:Cytokine driven inflammation is a common feature in autoimmune diseases. Cytokines are needed under physiological conditions within the innate and adaptive immune systems to control infectious diseases and neoplastic disorders by regulation of the cell cycle and apoptosis. Cytokines can also be found in persistently increased concentrations in inflamed tissues within autoimmune diseases. Therefore, the modulation of cytokines seems to be a worthwhile therapeutic approach. With TNFalpha and Il-1, two key cytokines in rheumatoid arthritis have been identified. Their inhibition leads to a convincing clinical benefit. In the near future, inhibition of additional cytokines, such as Il-6 or Il-15, will likely open new beneficial strategies.
journal_name
Z Rheumatoljournal_title
Zeitschrift fur Rheumatologieauthors
Feuchtenberger M,Kneitz C,Tony HPdoi
10.1007/s00393-007-0176-2subject
Has Abstractpub_date
2007-07-01 00:00:00pages
297-8, 300-3issue
4eissn
0340-1855issn
1435-1250journal_volume
66pub_type
杂志文章,评审abstract：BACKGROUND:Early detection of patients with axial spondylarthritis (axSpA) in primary care is difficult. The combination of various parameters indicative of inflammatory back pain (AWARE criteria) was found to be beneficial in an initial study. OBJECTIVE:Review of the criteria for the identification of young patients ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-018-0550-2
更新日期：2019-08-01 00:00:00
abstract：:MicroRNAs are small non-coding RNAs which are crucial for the fine regulation of gene expression. Recent results suggest that these molecules display multifaceted functions in B-cells and T-cells in rheumatic inflammatory diseases. ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-011-0842-2
更新日期：2011-08-01 00:00:00
abstract：:In an intraindividual series of investigation consisting of 30 patients with rheumatoid arthritis the effect of gold therapy (Aurothioglucose) has been proved controlling biochemical and clinical parameters. Controls of the function-index by Steinbrocker et al. have shown a significant improvement in comparison with t...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1975-05-01 00:00:00
abstract：:Aortic aneurysm and dissection are rare complications of systemic lupus erythematosus (SLE). The incidence, etiology, risk factors, and outcomes of this entity were largely unknown.The study materials were based on the publications of aortic aneurysm or dissection due to SLE published between 2000 and 2017.A total of ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-018-0555-x
更新日期：2019-04-01 00:00:00
abstract：:Patients with various kinds of intestinal illnesses sometimes suffer not only abdominal symptoms, but also joint involvement, leading to a reduction in quality of life. Diseases leading to inflammatory joint involvement such as inflammatory bowel disease, Whipple's disease or surgical intestinal bypass, are classified...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-009-0465-z
更新日期：2009-06-01 00:00:00
abstract：:Certolizumab pegol is a new anti-TNF-alpha inhibitor which has been approved for the treatment of rheumatoid arthritis since October 2009. Due to the modification of the antibody fragment by the adherence of polyethylene glycol (PEG) a sufficient distribution in inflammatory tissue was found in animal experiments. In ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-010-0629-x
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease with a prevalence of up to 1 % in the adult population. OBJECTIVE:This study describes the prevalence of RA diagnoses in outpatient health insurance claims data, based on different case definitions and stratified by age, sex and...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-016-0088-0
更新日期：2016-10-01 00:00:00
abstract：:The antidesoxyribonuclease B reaction shows in persons of all classes of age examined a similar distribution of titres as the antistreptolysin reaction. The anti DNase B titres however are mostly lower than the titres of the antistreptolysin reaction, except in the group of children, 6 to 17 years of age, suffering fr...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Patients with rheumatic diseases need a comprehensive and interdisciplinary treatment. In this context patient education takes the part to lead patients to a better self-management. The goals of patient education are the increase of knowledge and introspection, the positive influencing of attitudes and self-efficacy a...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-003-1202-7
更新日期：2003-01-01 00:00:00
abstract：:Rheumatoid vasculitis usually occurs on the background of seropositive rheumatoid arthritis, although in rare cases the patients can be seronegative. We report a woman with seronegative rheumatoid arthritis with rheumatoid vasculitis who developed toxic epidermal necrolysis involving most of her body surface area, whi...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-015-1632-z
更新日期：2016-03-01 00:00:00
abstract：:Neuro-endocrine immune mechanisms play an important immunomodulatory role for rheumatic diseases as evidenced by long-recognized effects of glucocorticoids, gender, pregnancy, hemiparalysis, and stress on various clinical and epidemiological aspects. Recently, some regulatory pathways have been identified between the ...
journal_title：Zeitschrift fur Rheumatologie
pub_type：
doi：10.1007/s003930200032
更新日期：2002-04-01 00:00:00
abstract：:Polyarthralgias are widely common complaints. In earlier stages it might be difficult to state the right diagnosis. Differential diagnosis is absolutely necessary for starting in time with the right treatment. Out of a great clinical material the following diseases causing mono-, oligo- or polyarthralgia were discusse...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The treatment of rheumatic diseases with bioloics has significantly improved the prognosis of patients. Currently, there are 13 preparations available in Germany for the treatment of patients with inflammatory rheumatic diseases. These original preparations generally have-depending on the individual country-15 years o...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-017-0407-0
更新日期：2018-02-01 00:00:00
abstract：:Due to the relative increase of age-diabetes and to the different forms of rheumatic diseases, long-term medicament therapy and the question of possible interactions between oral antidiabetic drugs ( OAD ) and nonsteroidal anti-inflammatory drugs (NSAID) become more important. Unfortunately there exist studies on most...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：BACKGROUND:Clinical observation suggests a frequent coincidence of back pain (BP) and fibromyalgia (FMA). Based on data from a population survey on back pain we studied the hypothesis of FMA being a frequent underlying condition of BP. We additionally studied the association of the severity of back pain and both chroni...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-004-0531-5
更新日期：2004-02-01 00:00:00
abstract：:Osteoid osteomas are painful bone tumors that usually occur in childhood or adolescence. Despite the small size of the bony lesions osteoid osteomas can cause persistent pain. Pathogenesis has not been completely understood. Remission usually occurs within several months to years. Therefore surgical therapy is not ind...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-008-0262-0
更新日期：2008-03-01 00:00:00
abstract：:Over the last ten years various biologics have been introduced in the therapy of rheumatic diseases. The most successful approach so far has been the inhibition of TNF alpha, which is able to suppress systemic inflammation in an unprecedented manner. However, the early observation of newly developed antinuclear antibo...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-003-0530-y
更新日期：2003-06-01 00:00:00
abstract：:Fiftythree patients with progressive systemic sclerosis were studied. Four of them (3 males) had the diffuse form of the disease. The skin manifestation of this clinical picture is characterized by diffuse progression of the cutaneous sclerosis over almost the whole body surface, except for the hands where it eventual...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:Rheumatoid arthritis (RA) represents an autoimmune disease affecting mostly joints, in particular small finger and toe joints. In addition RA can show extra-articular manifestations in many organs. Information on the frequency of extra-articular manifestations (EAMs) in RA varies greatly in different publications from...
journal_title：Zeitschrift fur Rheumatologie
pub_type：
doi：10.1007/s00393-011-0928-x
更新日期：2012-12-01 00:00:00
abstract：:The case described concerns a patient initially presenting the clinical symptoms of rheumatoid arthritis, including the presence of nodules, and slowly developing into systemic lupus erythematosus (SLE). Besides the signs of chronic inflammation in the synovial tissue, many granulocytes and PAS-positive macrophages we...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
abstract：:NSAIDs, including acetylsalicylic acid, are frequently classified as peripherally-acting analgesics. This is based on the fact that these substances, among other effects, inhibit the biosynthesis of prostaglandines. A few solid arguments, however, stand against an exclusively peripheral mode of the analgesic action of...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:In rheumatic diseases, radiation synovectomy is a reliable method. Meanwhile, radiation synovectomy is an outpatient therapy. In addition, combination with arthroscopic synovectomy is an increasing therapeutic modality. In comparison to the hitherto inpatient modality, a greater lymphatic emigration of the radionuclid...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s003930050172
更新日期：1999-08-01 00:00:00
abstract：:Inflammatory myopathies are as a rule rare diseases of skeletal muscle. In the majority of cases noninfective autoimmunological reactions are assumed. Only few diseases have an infectious origin. From a myopathological point of view, polymyositis must be selected from interstitial nodular myositis. The most important ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are associated with increased mortality, largely as a consequence of cardiovascular (CV) disease. Studies found relative risk ratios of 2 for myocardial infarction in RA and up to 7 for myocardial infarction in SLE patients.Beyond the traditional CV risk...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-009-0585-5
更新日期：2010-10-01 00:00:00
abstract：:Systemic juvenile idiopathic arthritis (sJIA) is characterized by fever, arthritis, and other signs of systemic inflammation. Historically, sJIA was named Still's disease after George Frederic Still, who first reported patients. Individuals who manifest after the 16th birthday are diagnosed with adult onset Still's di...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-017-0358-5
更新日期：2017-09-01 00:00:00
abstract：:Peripheral blood lymphocytes of patients with rheumatoid arthritis, psoriatic arthritis and healthy controls, isolated by a ficoll density gradient, were incubated with different concentrations of histamine, cimetidine and diphenhydramine (DPH) and simultaneously stimulated with phytohemagglutinine (PHA). In compariso...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：:Various rheumatic symptoms can occur in association with malignancies and are termed the so-called paraneoplastic arthropathy. The clinical picture is often similar to primary inflammatory rheumatic diseases. At present there exist no epidemiological data on this disease entity. The case of a patient with tibial pain ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-010-0734-x
更新日期：2011-06-01 00:00:00
abstract：:The sulfhydryl groups are chemically active parts of the protein molecule and participate in many important biochemical and metabolic processes. The present material comprised 132 patients with rheumatoid arthritis, 104 patients with other diseases and 44 controls. The patients with rheumatoid arthritis had decreased ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:Diagnosis and management of the rare disease systemic sclerosis (scleroderma) is a challenge for the physician, not least due to the possible multitude of organ systems involved. The medico-legal assessment is important for the patient claiming insurance benefits or applying for early retirement due to scleroderma. Bo...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-007-0206-0
更新日期：2007-10-01 00:00:00
abstract：INTRODUCTION:Data with respect to safety and therapeutic efficacy for the combination of biological DMARDs is scarce and inhomogeneous in order to make final conclusions. To this end, data to biologic combinations is disappointing due to relatively low therapeutic efficacy and partially enhanced rates of severe infecti...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-013-1141-x
更新日期：2013-11-01 00:00:00
