Does the medial thalamus play a role in the negative affective component of visceral pain in rats?

Abstract:

:Pain consists of sensory and negative affective components. Using a conditioned place aversion (CPA) paradigm, we investigated whether the medial thalamus (MT) played a role in the affective component of visceral pain induced by intraperitoneal injection of acetic acid into male Long-Evan rats. Acetic acid produced writhing response as well as CPA. The bilateral MT-lesions resulted in slight reduction of writhing response, but CPA was not affected. The results suggest that while MT may play a role in visceral nociception, it does not participate in the negative affective component of visceral pain.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Wang HC,Chai SC,Wu YS,Wang CC

doi

10.1016/j.neulet.2007.04.064

subject

Has Abstract

pub_date

2007-06-08 00:00:00

pages

80-4

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(07)00530-7

journal_volume

420

pub_type

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