Abstract:
:The ability of the endospore-forming, gram-positive bacterium Bacillus anthracis to survive in activated macrophages is key to its germination and survival. In a previous publication, we discovered that exposure of primary murine macrophages to B. anthracis endospores upregulated NOS 2 concomitant with an .NO-dependent bactericidal response. Since NOS 2 also generates O(2).(-), experiments were designed to determine whether NOS 2 formed peroxynitrite (ONOO(-)) from the reaction of .NO with O(2).(-) and if so, was ONOO(-) microbicidal toward B. anthracis. Our findings suggest that ONOO(-) was formed upon macrophage infection by B. anthracis endospores; however, ONOO(-) does not appear to exhibit microbicidal activity toward this bacterium. In contrast, the exosporium of B. anthracis, which exhibits arginase activity, protected B. anthracis from macrophage-mediated killing by decreasing .NO levels in the macrophage. Thus, the ability of B. anthracis to subvert .NO production has important implications in the control of B. anthracis-induced infection.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Weaver J,Kang TJ,Raines KW,Cao GL,Hibbs S,Tsai P,Baillie L,Rosen GM,Cross ASdoi
10.1128/IAI.00283-07subject
Has Abstractpub_date
2007-08-01 00:00:00pages
3894-901issue
8eissn
0019-9567issn
1098-5522pii
IAI.00283-07journal_volume
75pub_type
杂志文章abstract::We show here that Helicobacter pylori broth culture supernatants disrupt the actin cytoskeleton of epithelial cell lines, leading to cell rounding and apoptosis through anoikis. We demonstrate that there are marked quantitative differences between strains and that there are different cell line sensitivities. By constr...
journal_title:Infection and immunity
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doi:10.1128/iai.71.6.3623-3627.2003
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abstract::The action of trehalose-6, 6'-dimycolate (cord factor) of Mycobacterium tuberculosis to induce site II-specific inhibition of mitochondrial oxidative phosphorylation and to stimulate adenosine triphosphatase activity was neutralized by its specific antibody. The activity was restored after dissociation of cord factor ...
journal_title:Infection and immunity
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doi:10.1128/IAI.10.1.277-279.1974
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.6.5.835-851.1972
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.3.1695-1705.2005
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.60.10.4140-4145.1992
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journal_title:Infection and immunity
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doi:10.1128/IAI.16.2.471-475.1977
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.23.1.181-183.1979
更新日期:1979-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.11.4629-4636.1993
更新日期:1993-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.7.2204-2213.1990
更新日期:1990-07-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.7.4.597-599.1973
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.3.425-429.1973
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.5.1860-1866.1994
更新日期:1994-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.7.4358-4360.2000
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.1.269-276.1996
更新日期:1996-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.7.3637-3640.1999
更新日期:1999-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.3.1126-1135.1983
更新日期:1983-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.5.1127-1134.1974
更新日期:1974-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.2.386-394.1986
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journal_title:Infection and immunity
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更新日期:1988-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.5.2241-2249.1999
更新日期:1999-05-01 00:00:00
abstract::IL12RB1 is a human gene that is important for resistance to Mycobacterium tuberculosis infection. IL12RB1 is expressed by multiple leukocyte lineages, and encodes a type I transmembrane protein (IL12Rβ1) that associates with IL12p40 and promotes the development of host-protective T(H)1 cells. Recently, we observed tha...
journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2018-08-22 00:00:00